Coding constraints modulate chemically spontaneous mutational replication gradients in mitochondrial genomes [0.03%]
编码限制调节线粒体基因组中的化学自发突变复制梯度
Hervé Seligmann
Hervé Seligmann
Distances from heavy and light strand replication origins determine duration mitochondrial DNA remains singlestranded during replication. Hydrolytic deaminations from A->G and C->T occur more on single- than doublestranded DNA. Correspondin...
Replication-Associated Mutational Pressure (RMP) Governs Strand-Biased Compositional Asymmetry (SCA) and Gene Organization in Animal Mitochondrial Genomes [0.03%]
复制相关的突变压力（RMP）控制着动物线粒体基因组的链偏性组成不对称性和基因组织
Qiang Lin,Peng Cui,Feng Ding et al.
Qiang Lin et al.
The nucleotide composition of the light (L-) and heavy (H-) strands of animal mitochondrial genomes is known to exhibit strand-biased compositional asymmetry (SCA). One of the possibilities is the existence of a replication-associated mutat...
DNA replication and strand asymmetry in prokaryotic and mitochondrial genomes [0.03%]
原核及线粒体基因组的dna复制和链不对称性
Xuhua Xia
Xuhua Xia
Different patterns of strand asymmetry have been documented in a variety of prokaryotic genomes as well as mitochondrial genomes. Because different replication mechanisms often lead to different patterns of strand asymmetry, much can be lea...
Measures of compositional strand bias related to replication machinery and its applications [0.03%]
与复制机器相关的组成性链偏倚度量及其应用
Kazuharu Arakawa,Masaru Tomita
Kazuharu Arakawa
The compositional asymmetry of complementary bases in nucleotide sequences implies the existence of a mutational or selectional bias in the two strands of the DNA duplex, which is commonly shaped by strand-specific mechanisms in transcripti...
Feng-Biao Guo
Feng-Biao Guo
Christian Neri
Christian Neri
Alessandro Antonelli,Poupak Fallahi,Silvia M Ferrari et al.
Alessandro Antonelli et al.
The increasing incidence of thyroid cancer is associated with a higher number of advanced disease characterized by the loss of cancer differentiation and metastatic spread. The knowledge of the molecular pathways involved in the pathogenesi...
Genetic alterations in medullary thyroid cancer: diagnostic and prognostic markers [0.03%]
遗传学改变在髓样甲状腺癌中的作用：诊断和预后标志物
Taccaliti A,Silvetti F,Palmonella G et al.
Taccaliti A et al.
Medullary thyroid carcinoma (MTC) is a rare calcitonin producing neuroendocrine tumour that originates from the parafollicular C-cells of the thyroid gland. The RET proto-oncogene encodes the RET receptor tyrosine kinase, with consequently ...
Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas [0.03%]
分化不良甲状腺癌的基因改变
Paula Soares,Jorge Lima,Ana Preto et al.
Paula Soares et al.
Thyroid gland presents a wide spectrum of tumours derived from follicular cells that range from well differentiated, papillary and follicular carcinoma (PTC and FTC, respectively), usually carrying a good prognosis, to the clinically aggres...
José M Gómez Sáez
José M Gómez Sáez
The MAPK/ERK (mitogen-activated protein kinase/extracellular signal- regulated kinase signaling pathway) and PI3K/Akt (lipid kinase phoshoinositide-3-kinase signaling pathway) play an important role in transmission of cell signals through t...