Mariko Kondo,Koji Akasaka
Mariko Kondo
Echinoderms have long served as model organisms for a variety of biological research, especially in the field of developmental biology. Although the genome of the purple sea urchin Strongylocentrotus purpuratus has been sequenced, it is the...
Arnab Gupta,Svetlana Lutsenko
Arnab Gupta
Copper is an essential nutrient for most life forms, however in excess it can be harmful. The ATP-driven copper pumps (Copper-ATPases) play critical role in living organisms by maintaining appropriate copper levels in cells and tissues. The...
Yukako Katsura,Mineyo Iwase,Yoko Satta
Yukako Katsura
Throughout mammalian evolution, recombination between the two sex chromosomes was suppressed in a stepwise manner. It is thought that the suppression of recombination led to an accumulation of deleterious mutations and frequent genomic rear...
Olfactory receptor multigene family in vertebrates: from the viewpoint of evolutionary genomics [0.03%]
从进化基因组学的角度看脊椎动物的嗅觉受体多基因家族
Yoshihito Niimura
Yoshihito Niimura
Olfaction is essential for the survival of animals. Diverse odor molecules in the environment are detected by the olfactory receptors (ORs) in the olfactory epithelium of the nasal cavity. There are ~400 and ~1,000 OR genes in the human and...
Sabyasachi Das,Masayuki Hirano,Rea Tako et al.
Sabyasachi Das et al.
Immunoglobulins (or antibodies) are an essential element of the jawed vertebrate adaptive immune response system. These molecules have evolved over the past 500 million years and generated highly specialized proteins that recognize an extra...
Immune related genes underpin the evolution of adaptive immunity in jawless vertebrates [0.03%]
免疫相关基因揭示无颌脊椎动物适应性免疫的进化基础
Nathanael McCurley,Masayuki Hirano,Sabyasachi Das et al.
Nathanael McCurley et al.
The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem o...
Sabyasachi Das,Masayuki Hirano
Sabyasachi Das
Using genetic networks and homology to understand the evolution of phenotypic traits [0.03%]
利用基因网络和同源性理解表型特征的进化
Amy R McCune,John C Schimenti
Amy R McCune
Homology can have different meanings for different kinds of biologists. A phylogenetic view holds that homology, defined by common ancestry, is rigorously identified through phylogenetic analysis. Such homologies are taxic homologies (=syna...
Interference between DNA replication and transcription as a cause of genomic instability [0.03%]
DNA复制与转录之间的干扰是基因组不稳定的诱因
Yea-Lih Lin,Philippe Pasero
Yea-Lih Lin
Replication and transcription are key aspects of DNA metabolism that take place on the same template and potentially interfere with each other. Conflicts between these two activities include head-on or co-directional collisions between DNA ...
A blueprint for a mutationist theory of replicative strand asymmetries formation [0.03%]
一种关于复制链不对称性形成的变异论理论的构想
Vladislav V Khrustalev,Eugene V Barkovsky
Vladislav V Khrustalev
In the present review, we summarized current knowledge on replicative strand asymmetries in prokaryotic genomes. A cornerstone for the creation of a theory of their formation has been overviewed. According to our recent works, the probabili...