Mouse models of genomic syndromes as tools for understanding the basis of complex traits: an example with the smith-magenis and the potocki-lupski syndromes [0.03%]
基因组综合征的小鼠模型作为理解复杂性状发病机制的工具——史密斯-马吉尼斯综合症和波图奇-路普斯基综合症为例
P Carmona-Mora,J Molina,C A Encina et al.
P Carmona-Mora et al.
Each human's genome is distinguished by extra and missing DNA that can be "benign" or powerfully impact everything from development to disease. In the case of genomic disorders DNA rearrangements, such as deletions or duplications, correlat...
Involvement of nucleotide excision and mismatch repair mechanisms in double strand break repair [0.03%]
核苷酸切除修复和错配修复机制参与双链断裂修复
Ye Zhang,Larry H Rohde,Honglu Wu
Ye Zhang
Living organisms are constantly threatened by environmental DNA-damaging agents, including UV and ionizing radiation (IR). Repair of various forms of DNA damage caused by IR is normally thought to follow lesion-specific repair pathways with...
An outlook on ovarian cancer and borderline ovarian tumors: focus on genomic and proteomic findings [0.03%]
卵巢癌和交界性肿瘤的展望：重点介绍基因组学和蛋白质组学的研究成果
Andrea Tinelli,Daniele Vergara,Roberta Martignago et al.
Andrea Tinelli et al.
Among the gynaecological malignancies, ovarian cancer is one of the neoplastic forms with the poorest prognosis and with the bad overall and disease-free survival rates than other gynaecological cancers. Ovarian tumors can be classified on ...
Joshua Rother,Dan Jones
Joshua Rother
Malignant melanoma represents one of the most aggressive malignancies but outcome is highly variable with early tumor lesions having an excellent prognosis following resection. We review here the data on identification of genes involved in ...
Control of the bone morphogenetic protein 7 gene in developmental and adult life [0.03%]
骨形态生成蛋白7基因的发育和生后表达调控研究
Leif Oxburgh
Leif Oxburgh
The TGFbeta superfamily growth factor BMP7 performs essential biological functions in embryonic development and regeneration of injured tissue in the adult. BMP7 activity is regulated at numerous levels in the signaling pathway by the expre...
Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC [0.03%]
肿瘤抑制/易感基因介导的鼻咽癌信号转导网络
Minghua Wu,Xiayu Li,Xiaoling Li et al.
Minghua Wu et al.
Nasopharyngeal carcinoma (NPC) is a polygenetic disease. SPLUNC1, UBAP1, BRD7, NAG7, NOR1, NGX6 and LTF genes were found to be tumor suppressor/susceptibility genes in different stages of NPC. SPLUNC1, an early warning molecular diagnosis m...
Regulation of interactions with sliding clamps during DNA replication and repair [0.03%]
DNA复制和修复过程中滑动夹相互作用的调节
Francisco J López de Saro
Francisco J López de Saro
The molecular machines that replicate the genome consist of many interacting components. Essential to the organization of the replication machinery are ring-shaped proteins, like PCNA (Proliferating Cell Nuclear Antigen) or the beta- clamp,...
Coordination of Ribosomal Protein and Ribosomal RNA Gene Expression in Response to TOR Signaling [0.03%]
靶向TOR信号的核糖体蛋白质和核糖体RNA基因表达协调作用
Lijuan Xiao,Anne Grove
Lijuan Xiao
Cells grow in response to nutrients or growth factors, whose presence is detected and communicated by elaborate signaling pathways. Protein kinases play crucial roles in processes such as cell cycle progression and gene expression, and misr...
Apana Takwi,Yong Li
Apana Takwi
The p53 protein is a transcription factor that regulates multiple cellular processes in human and other high eukaryotes including cell proliferation, differentiation, cell cycle, and metabolism. The central roles played by p53 in tumor deve...
Ruqiang Liang,David J Bates,Eugenia Wang
Ruqiang Liang
MicroRNAs are a major category among the noncoding RNA fraction that negatively regulate gene expression at the post-transcriptional level, by either degrading the target messages or inhibiting their translation. MicroRNAs may be referred t...