The Story of SPATA2 (Spermatogenesis-Associated Protein 2): From Sertoli Cells to Pancreatic Beta-Cells [0.03%]
SPATA2（精子发生相关蛋白2）的故事：从支持细胞到胰岛β细胞
Claudio Maran,Evelyne Tassone,Valentina Masola et al.
Claudio Maran et al.
In an attempt to isolate new spermatogenesis-associated genes, pd1 was initially identified and cloned as a novel human cDNA sequence from testis cDNA library. The novel gene was submitted to GenBank under accession n degrees U28164 in 1996...
Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis [0.03%]
克鲁普佩尔样转录因子(KLFs)在肿瘤发生中的功能和作用机制研究进展
Christophe Bureau,Naima Hanoun,Jérôme Torrisani et al.
Christophe Bureau et al.
Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years sup...
Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy [0.03%]
DNA甲基转移酶及其表观遗传调控在肺癌治疗中的潜力
Mingqing Tang,William Xu,Qizhao Wang et al.
Mingqing Tang et al.
Lung cancer, the leading cause of mortality in both men and women in the United States, is largely diagnosed at its advanced stages that there are no effective therapeutic alternatives. Although tobacco smoking is the well established cause...
CENPA a genomic marker for centromere activity and human diseases [0.03%]
染色体蛋白CENPA是着丝粒活性和人类疾病的一个基因组标志物
Manuel M Valdivia,Khaoula Hamdouch,Manuela Ortiz et al.
Manuel M Valdivia et al.
Inheritance of genetic material requires that chromosomes segregate faithfully during cell division. Failure in this process can drive to aneuploidy phenomenon. Kinetochores are unique centromere macromolecular protein structures that attac...
One Decade Later: What has Gene Expression Profiling Told us About Neuronal Cell Types, Brain Function and Disease? [0.03%]
十年之后：基因表达谱分析告诉我们关于神经元细胞类型、脑功能和疾病哪些信息？
Elva Díaz
Elva Díaz
The many diverse functions executed by the central nervous system (CNS) are mirrored in the diverse shapes, connections, and firing patterns of its individual neuronal cell types. Furthermore, distinct neurological diseases are the result o...
Aurelia Busca,Mansi Saxena,Marko Kryworuchko et al.
Aurelia Busca et al.
Macrophages are cells of the immune system that protect organisms against invading pathogens by fulfilling critical roles in innate and adaptive immunity and inflammation. They originate from circulating monocytes and show a high degree of ...
Cell Therapy Using Induced Pluripotent Stem (iPS) Cells Meets Next-Next Generation DNA Sequencing Technology [0.03%]
诱导多能干细胞(iPSC)的细胞治疗迎来下一代DNA序列技术
Manabu Nakayama
Manabu Nakayama
The recent development of induced pluripotent stem (iPS) cell technology brings cell and gene therapies to patients one large step closer to reality. Technical improvements in various research fields sometimes come together fortuitously, le...
Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity [0.03%]
脊椎动物蛋白质CTCF及其在大规模调控基因组活性中的多种作用
L G Nikolaev,S B Akopov,D A Didych et al.
L G Nikolaev et al.
The CTCF transcription factor is an 11 zinc fingers multifunctional protein that uses different zinc finger combinations to recognize and bind different sites within DNA. CTCF is thought to participate in various gene regulatory networks in...
E Kirches
E Kirches
Although the observation of aerobic glycolysis of tumor cells by Otto v. Warburg had demonstrated abnormalities of mitochondrial energy metabolism in cancer decades ago, there was no clear evidence for a functional role of mutant mitochondr...
Fu-Tai Ni,Li-Ye Chu,Hong-Bo Shao et al.
Fu-Tai Ni et al.
Higher plants not only provide human beings renewable food, building materials and energy, but also play the most important role in keeping a stable environment on earth. Plants differ from animals in many aspects, but the important is that...