Inderpreet Sur
Inderpreet Sur
Krüppel-like factors (Klf) 4 and 5 belong to a family of zinc finger-containing transcription factors that share homology with the Drosophila gene Krüppel. They regulate proliferation and differentiation of a wide variety of cells and hav...
Do mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinson's Disease? [0.03%]
线粒体DNA变异参与散发性帕金森病的发病过程吗？
E Kirches
E Kirches
The pathogenesis of sporadic Parkinson's disease (PD) remains enigmatic. Mitochondrial complex-I defects are known to occur in the substantia nigra (SN) of PD patients and are also debated in some extracerebral tissues. Early sequencing eff...
Perspectives in cell cycle regulation: lessons from an anoxic vertebrate [0.03%]
细胞周期调控研究进展——无氧生物的启示
Kyle K Biggar,Kenneth B Storey
Kyle K Biggar
The ability of an animal, normally dependent on aerobic respiration, to suspend breathing and enter an anoxic state for long term survival is clearly a fascinating feat, and has been the focus of numerous biochemical studies. When anoxia to...
Getting a grip on complexes [0.03%]
把握住复合物
Yan Nie,Cristina Viola,Christoph Bieniossek et al.
Yan Nie et al.
We are witnessing tremendous advances in our understanding of the organization of life. Complete genomes are being deciphered with ever increasing speed and accuracy, thereby setting the stage for addressing the entire gene product repertoi...
Natália Freitas,Celso Cunha
Natália Freitas
In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of macromolecules from and into the cytoplasm. Nucleocytoplasmic traffic occurs through highly specialized structures known as nuclear pores, and invol...
R V L Joosen,W Ligterink,H W M Hilhorst et al.
R V L Joosen et al.
Natural variation provides a valuable resource to study the genetic regulation of quantitative traits. In quantitative trait locus (QTL) analyses this variation, captured in segregating mapping populations, is used to identify the genomic r...
Wei Guo,Yao-Guang Jiang
Wei Guo
Esophageal carcinoma is one of the deadliest cancers with highly aggressive potency, ranking as the sixth most common cancer among males and ninth most common cancer among females globally. Due to metastasis and invasion of surrounding tiss...
Telomeres and thyroid cancer [0.03%]
端粒和甲状腺癌
Marco Capezzone,Stefania Marchisotta,Silvia Cantara et al.
Marco Capezzone et al.
Telomeres are specialized structures at the ends of chromosomes, consisting of hundreds of repeated hexanucleotides (TTAGGG)n. Genetic integrity is partly maintained by the architecture of telomeres and it is gradually lost as telomeres pro...
A tutorial on analysis and simulation of boolean gene regulatory network models [0.03%]
布尔基因调控网络模型的分析与模拟教程
Yufei Xiao
Yufei Xiao
Driven by the desire to understand genomic functions through the interactions among genes and gene products, the research in gene regulatory networks has become a heated area in genomic signal processing. Among the most studied mathematical...
Signal processing for metagenomics: extracting information from the soup [0.03%]
信号处理在宏基因组学中的应用——从“信号汤”中提取信息
Gail L Rosen,Bahrad A Sokhansanj,Robi Polikar et al.
Gail L Rosen et al.
Traditionally, studies in microbial genomics have focused on single-genomes from cultured species, thereby limiting their focus to the small percentage of species that can be cultured outside their natural environment. Fortunately, recent a...