Comparative Approach of the de novo Fatty Acid Synthesis (Lipogenesis) between Ruminant and Non Ruminant Mammalian Species: From Biochemical Level to the Main Regulatory Lipogenic Genes [0.03%]
反刍动物与非反刍动物从头合成脂肪酸（脂质生成）的比较研究：从生化水平到主要脂质生成调控基因
G P Laliotis,I Bizelis,E Rogdakis
G P Laliotis
Over the second half of 20(th) century much research on lipogenesis has been conducted, especially focused on increasing the production efficiency and improving the quality of animal derived products. However, many diferences are observed i...
M Boettcher,J D Hoheisel
M Boettcher
RNA interference (RNAi) screens have recently emerged as an exciting new tool for studying gene function in mammalian cells. In order to facilitate those studies, short hairpin RNA (shRNA) expression libraries covering the entire human tran...
Rachel E Ellsworth,David J Decewicz,Craig D Shriver et al.
Rachel E Ellsworth et al.
Breast cancer is a heterogeneous disease with a complex etiology that develops from different cellular lineages, progresses along multiple molecular pathways, and demonstrates wide variability in response to treatment. The "standard of care...
Functional annotation of genes overlapping copy number variants in autistic patients: focus on axon pathfinding [0.03%]
自闭症患者基因拷贝数变异重叠的基因的功能注释：轴突导向研究重点
Silvia Sbacchi,Francesco Acquadro,Ignazio Calò et al.
Silvia Sbacchi et al.
We have used Gene Ontology (GO) and pathway analyses to uncover the common functions associated to the genes overlapping Copy Number Variants (CNVs) in autistic patients. Our source of data were four published studies [1-4]. We first applie...
Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis [0.03%]
敌人还是朋友？miR-17-92簇在肿瘤发生中的作用
Jie Xiang,Ji Wu
Jie Xiang
MicroRNAs (miRNAs) are short, noncoding, and single-stranded RNA molecules that negatively regulate gene expression. They are evolutionarily conserved from plants to animals. During the last decade, miRNAs have been demonstrated as regulato...
Martín Muñoz-López,José L García-Pérez
Martín Muñoz-López
Repeated DNA makes up a large fraction of a typical mammalian genome, and some repetitive elements are able to move within the genome (transposons and retrotransposons). DNA transposons move from one genomic location to another by a cut-and...
The Origin of Amerindians and the Peopling of the Americas According to HLA Genes: Admixture with Asian and Pacific People [0.03%]
美洲原住民的起源及人类迁入美洲的HLA基因组证据：与亚洲及太平洋人群的混合证据
A Arnaiz-Villena,C Parga-Lozano,E Moreno et al.
A Arnaiz-Villena et al.
The classical three-waves theory of American peopling through Beringia was based on a mixed anthropological and linguistic methodology. The use of mtDNA, Y chromosome and other DNA markers offers different results according to the different...
Luke E Berchowitz,Gregory P Copenhaver
Luke E Berchowitz
Meiosis is a dynamic process during which chromosomes undergo condensation, pairing, crossing-over and disjunction. Stringent regulation of the distribution and quantity of meiotic crossovers is critical for proper chromosome segregation in...
Benedikt Schoser,Lubov Timchenko
Benedikt Schoser
Two multi-system disorders, Myotonic Dystrophies type 1 and type 2 (DM1 and DM2), are complex neuromuscular diseases caused by an accumulation of expanded, non-coding RNAs, containing repetitive CUG and CCUG elements. Similarities of these ...
Investigation of molecular mechanism of chronic pain in the anterior cingulate cortex using genetically engineered mice [0.03%]
利用基因工程小鼠研究前扣带回慢性疼痛的分子机制
Susan S Kim,Giannina Descalzi,Min Zhuo
Susan S Kim
Recent advances into the understanding of molecular mechanism of chronic pain have been largely developed through the use of genetic manipulations. This is in part due to the scarcity of selective pharmacological tools, which can be readily...