Transcription Factor CHF1/Hey2 Regulates Specific Pathways in Serum Stimulated Primary Cardiac Myocytes: Implications for Cardiac Hypertrophy [0.03%]
转录因子CHF1/Hey2调控血清刺激下原代心脏成纤维细胞的特异信号通路：对心肌肥大的意义
Man Yu,Fan Xiang,Richard P Beyer et al.
Man Yu et al.
We have previously found that overexpression of CHF1/Hey2 in the myocardium prevents the development of phenylephrine-induced hypertrophy. To identify transcriptional pathways regulated by CHF1/Hey2, we cultured primary neonatal mouse cardi...
Jianbing Mu,Karl B Seydel,Adam Bates et al.
Jianbing Mu et al.
With the completion and near completion of many malaria parasite genome-sequencing projects, efforts are now being directed to a better understanding of gene functions and to the discovery of vaccine and drug targets. Inter- and intraspecie...
Denise Yan,Xue-Zhong Liu
Denise Yan
Lack of penetrance and variability of expression are common findings in nonsyndromic hearing loss with autosomal dominant mode of inheritance, but are also seen with recessive inheritance. Now we know that genotype cannot necessarily predic...
Thorsten Maass,Ioannis Sfakianakis,Frank Staib et al.
Thorsten Maass et al.
Microarray studies have successfully shed light on various aspects of the molecular mechanisms behind the development of hepatocellular carcinoma (HCC), such as the identification of novel molecular subgroups and the genetic profiles associ...
Fabio Coppedè
Fabio Coppedè
Alzheimer's disease (AD) represents the most common form of dementia in the elderly, characterized by progressive loss of memory and cognitive capacity severe enough to interfere with daily functioning and the quality of life. Rare, fully p...
The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases [0.03%]
人类成神经细胞瘤转化基因同源物1(GLI1)转录因子家族在基因调控和疾病中的作用
Hu Zhu,Hui-Wen Lo
Hu Zhu
Sonic hedgehog (Shh) signaling is critically important for embryogenesis and other cellular processes in which GLI transcription factors mediate the terminal effects of the pathway. GLI1, in particular, plays a significant role in human can...
Edward R Dougherty,Michael L Bittner
Edward R Dougherty
Because the basic unit of biology is the cell, biological knowledge is rooted in the epistemology of the cell, and because life is the salient characteristic of the cell, its epistemology must be centered on its livingness, not its constitu...
Cláudia S Baptista,Estela Bastos,Sara Santos et al.
Cláudia S Baptista et al.
TWIST1 is thought to be a novel oncogene. Understanding the molecular mechanisms regulating the TWIST1 gene expression profiles in tumor cells may give new insights regarding prognostic factors and novel therapeutic targets in veterinary on...
Replication origins and timing of temporal replication in budding yeast: how to solve the conundrum? [0.03%]
芽殖酵母的复制起点和时间复制：如何解决矛盾？
Matteo Barberis,Thomas W Spiesser,Edda Klipp
Matteo Barberis
Similarly to metazoans, the budding yeast Saccharomyces cereviasiae replicates its genome with a defined timing. In this organism, well-defined, site-specific origins, are efficient and fire in almost every round of DNA replication. However...
Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications [0.03%]
DNA损伤反应中的翻译后修饰调节机制研究进展
C Oberle,C Blattner
C Oberle
Damage to the genetic material can affect cellular function in many ways. Therefore, maintenance of the genetic integrity is of primary importance for all cells. Upon DNA damage, cells respond immediately with proliferation arrest and repai...