Are we Genomic Mosaics? Variations of the Genome of Somatic Cells can Contribute to Diversify our Phenotypes [0.03%]
我们是基因组镶嵌体吗？体细胞的基因组变化可以增加我们的表型多样性
P A Astolfi,F Salamini,V Sgaramella
P A Astolfi
Theoretical and experimental evidences support the hypothesis that the genomes and the epigenomes may be different in the somatic cells of complex organisms. In the genome, the differences range from single base substitutions to chromosome ...
Christoph P Bagowski,Wouter Bruins,Aartjan J W Te Velthuis
Christoph P Bagowski
The proteomes that make up the collection of proteins in contemporary organisms evolved through recombination and duplication of a limited set of domains. These protein domains are essentially the main components of globular proteins and ar...
Genetics talks to epigenetics? The interplay between sequence variants and chromatin structure [0.03%]
基因和表观遗传的对话？序列变异与染色质结构之间的相互作用
Silvio Zaina,Elva L Pérez-Luque,Gertrud Lund
Silvio Zaina
Transcription is regulated by two major mechanisms. On the one hand, changes in DNA sequence are responsible for genetic gene regulation. On the other hand, chromatin structure regulates gene activity at the epigenetic level. Given the fund...
Functional genomics: new insights into the 'function' of low levels of gene expression in stem cells [0.03%]
功能基因组学：干细胞中低水平基因表达的“功能”的新见解
Jennifer A Hipp,Jason D Hipp,Anthony Atala et al.
Jennifer A Hipp et al.
Understanding the global gene expression profile of stem cells and their multilineage differentiation will be essential for their ultimate therapeutic application. Efforts to characterize stem cells have relied on analyzing the genome-wide ...
The Fuzzy Logic of MicroRNA Regulation: A Key to Control Cell Complexity [0.03%]
微小核糖核酸调控的模糊逻辑：控制细胞复杂性的关键
Andrea Ripoli,Giuseppe Rainaldi,Milena Rizzo et al.
Andrea Ripoli et al.
Genomic and clinical evidence suggest a major role of microRNAs (miRNAs) in the regulatory mechanisms of gene expression, with a clear impact on development and physiology; miRNAs are a class of endogenous 22-25 nt single-stranded RNA molec...
Shih-Chi Hsu,Mark F Belmonte,John J Harada et al.
Shih-Chi Hsu et al.
The plastid is an organelle vital to all photosynthetic and some non-photosynthetic eukaryotes. In the model plant Arabidopsis thaliana, a number of nuclear genes encoding plastid proteins have been found to be necessary for embryo developm...
DNA instability at chromosomal fragile sites in cancer [0.03%]
染色体脆性位点在癌症中的作用及机制研究进展——从DNA损伤到遗传不稳定性增强子
Laura W Dillon,Allison A Burrow,Yuh-Hwa Wang
Laura W Dillon
Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks on metaphase chromosomes following conditions of partial replication stress. Fragile sites often coincide with genes that are frequently rearranged or...
G Zhang,Q Wang,R Xu
G Zhang
Hepatocellular carcinoma (HCC) is a serious public health hazard. Polygenes involvement, accumulation of genetic and epigenetic changes and immune response of viral vector during gene therapy have resulted in the high mortality rate without...
Discovering tumor suppressor genes through genome-wide copy number analysis [0.03%]
通过全基因组拷贝数分析发现抑癌基因
S Michael Rothenberg,Jeff Settleman
S Michael Rothenberg
Classical tumor suppressor gene discovery has largely involved linkage analysis and loss-of-heterozygosity (LOH) screens, followed by detailed mapping of relatively large chromosomal regions. Subsequent efforts made use of genome-wide PCR-b...