Dihydrofolate reductase gene variations in susceptibility to disease and treatment outcomes [0.03%]
二氢叶酸还原酶基因多态性与疾病易感性和治疗效果的关系研究
Bahram S Askari,Maja Krajinovic
Bahram S Askari
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent enzymes and is thus essential for DNA synthesis and methylation. The importance of this reac...
Athanasia Pavlopoulou,Sophia Kossida
Athanasia Pavlopoulou
Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by...
Development of calorie restriction mimetics as therapeutics for obesity, diabetes, inflammatory and neurodegenerative diseases [0.03%]
研发模拟摄食限制的药物治疗肥胖、糖尿病、炎症和神经退行性疾病
Takuya Chiba,Tomoshi Tsuchiya,Toshimitsu Komatsu et al.
Takuya Chiba et al.
Calorie restriction (CR) is the most robust intervention that decreases morbidity and mortality, and thereby increases the lifespan of many organisms. Although the signaling pathways involved in the beneficial effects of CR are not yet full...
Leigh-Ann Macfarlane,Paul R Murphy
Leigh-Ann Macfarlane
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III, generating precursors that undergo a series of cleavage events to form ma...
Y Baskın,T Yiğitbaşı
Y Baskın
Despite the lifetimes that increased in breast cancers due to the the early screening programs and new therapeutic strategies, many cases still are being lost due to the metastatic relapses. For this reason, new approaches such as the prote...
Clinical, Molecular, and Genetic Characteristics of PAPA Syndrome: A Review [0.03%]
PAPA综合征的临床、分子和遗传特征综述
Elisabeth J Smith,Florence Allantaz,Lynda Bennett et al.
Elisabeth J Smith et al.
PAPA syndrome (Pyogenic Arthritis, Pyoderma gangrenosum, and Acne) is an autosomal dominant, hereditary auto-inflammatory disease arising from mutations in the PSTPIP1/CD2BP1 gene on chromosome 15q. These mutations produce a hyper-phosphory...
Luca Esposito,Daniele Conti,Ramyasri Ailavajhala et al.
Luca Esposito et al.
Lung cancer is the leading cause of cancer deaths worldwide among both men and women, with more than 1 million deaths annually. Non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancers.Although recent advances have been...
Plant plastid engineering [0.03%]
植物叶绿体工程学
Shabir H Wani,Nadia Haider,Hitesh Kumar et al.
Shabir H Wani et al.
Genetic material in plants is distributed into nucleus, plastids and mitochondria. Plastid has a central role of carrying out photosynthesis in plant cells. Plastid transformation is becoming more popular and an alternative to nuclear gene ...
Mark E Samuels
Mark E Samuels
The phenome is the complete set of phenotypes resulting from genetic variation in populations of an organism. Saturation of a phenome implies the identification and phenotypic description of mutations in all genes in an organism, potentiall...
Erratum: ERRATUM [0.03%]
错误:)错误
[This corrects the article on p. 103 in vol. 11.].
Published Erratum
Current genomics. 2010 Sep;11(6):481. DOI:10.2174/138920210793175985 2010