E Kirches
E Kirches
Leber's hereditary optic neuropathy (LHON) is a mitochondrial disorder leading to severe visual impairment or even blindness by death of retinal ganglion cells (RGCs). The primary cause of the disease is usually a mutation of the mitochondr...
Gulzar S Sanghera,Shabir H Wani,Wasim Hussain et al.
Gulzar S Sanghera et al.
Plants respond with changes in their pattern of gene expression and protein products when exposed to low temperatures. Thus ability to adapt has an impact on the distribution and survival of the plant, and on crop yields. Many species of tr...
Carcinoma of the Lower Uterine Segment (LUS): Clinicopathological Characteristics and Association with Lynch Syndrome [0.03%]
子宫下段癌（LUS）的临床病理特征及其与林奇综合征的关系
Kenta Masuda,Kouji Banno,Megumi Yanokura et al.
Kenta Masuda et al.
Endometrial cancer arises from the uterine body and fundus in many cases, but can also originate from the lower region of the uterine body through the upper region of the cervix. Such tumors are referred to as carcinoma of the lower uterine...
Yannick Delpu,Naïma Hanoun,Hubert Lulka et al.
Yannick Delpu et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Despite significant progresses in the last decades, the origin of this cancer remains unclear and no efficient therapy exists. PDAC does not arise de novo:...
Perspectives on Systematic Analyses of Gene Function in Arabidopsis thaliana: New Tools, Topics and Trends [0.03%]
拟南芥基因功能系统分析研究进展：新工具、新话题和趋势
C Bolle,A Schneider,D Leister
C Bolle
Since the sequencing of the nuclear genome of Arabidopsis thaliana ten years ago, various large-scale analyses of gene function have been performed in this model species. In particular, the availability of collections of lines harbouring ra...
Xue Q D Wang,Jennifer L Crutchley,Josée Dostie
Xue Q D Wang
The human genome must be tightly packaged in order to fit inside the nucleus of a cell. Genome organization is functional rather than random, which allows for the proper execution of gene expression programs and other biological processes. ...
Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability [0.03%]
大脑衰老和阿尔茨海默病的功能基因组学：重点关注选择性神经元脆弱性
Xinkun Wang,Mary L Michaelis,Elias K Michaelis
Xinkun Wang
Pivotal brain functions, such as neurotransmission, cognition, and memory, decline with advancing age and, especially, in neurodegenerative conditions associated with aging, such as Alzheimer's disease (AD). Yet, deterioration in structure ...
Retinoic Acid Induced 1, RAI1: A Dosage Sensitive Gene Related to Neurobehavioral Alterations Including Autistic Behavior [0.03%]
视黄酸诱导基因1（RAI1）与包括自闭症在内的神经行为异常相关性研究进展
Paulina Carmona-Mora,Katherina Walz
Paulina Carmona-Mora
Genomic structural changes, such as gene Copy Number Variations (CNVs) are extremely abundant in the human genome. An enormous effort is currently ongoing to recognize and catalogue human CNVs and their associations with abnormal phenotypic...
Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases [0.03%]
白细胞介素1受体样1基因与免疫和炎症性疾病的关系研究进展
Loubna Akhabir,Andrew Sandford
Loubna Akhabir
Interleukin 1 receptor-like 1 (IL1RL1) is gaining in recognition due to its involvement in immune/inflammatory disorders. Well-designed animal studies have shown its critical role in experimental allergic inflammation and human in vitro stu...
Role of NFAT5 in inflammatory disorders associated with osmotic stress [0.03%]
NFAT5在渗透压应激相关炎症性疾病中的作用
Wolfgang Neuhofer
Wolfgang Neuhofer
Nuclear factor of activated T cells 5 (NFAT5) is the most recently described member of the Rel family of transcription factors, including NF-κB and NFAT1-4, which play central roles in inducible gene expression during the immune response. ...