Wei-dang Wu,Xiu-lin Yi,Li-xin Jiang et al.
Wei-dang Wu et al.
The liposome delivery system has been intensively explored as novel drug delivery system (DDS) for antitumor drugs, due to its safety, selective cytotoxicity, long circulation and slow elimination in blood, which is favorable for cancer the...
Interplay of Breast Cancer Resistance Protein (BCRP) and Metabolizing Enzymes [0.03%]
乳腺癌耐药蛋白(BCRP)和代谢酶之间的相互作用
Ye Tian,Yicong Bian,Yan Jiang et al.
Ye Tian et al.
The recent identification of the interplay between metabolizing enzymes and BCRP has drawn more and more attention from people. BCRP, a transporter belonging to ATP-binding cassette (ABC) family, has been hypothesized to play roles in many ...
Drug Metabolizing Enzymes in Type II Diabetes and their Pharmacogenetics During Therapy of Anti-Diabetes Drugs [0.03%]
糖尿病2型糖代谢酶及其抗糖尿病药物治疗期间的药物基因组学研究进展
Chiranjib Chakraborty,Minna J Hsu,Govindasamy Agoramoorthy
Chiranjib Chakraborty
The type 2 diabetes or T2D mellitus has turn into an epidemic throughout the globe in recent years. Various forms of treatment modalities have been available for patients with T2D with some major classes of approved drugs that include Sulfo...
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers [0.03%]
细胞色素P450(CYP)代谢酶活化促癌原的作用及其基因多态性与癌症易感性的关系研究进展
Xin He,Shan Feng
Xin He
Cytochrome P450 (CYP450) enzymes are the most important metabolizing enzyme family exists among all organs. Apart from their role in the deactivation of most endogenous compounds and xenobiotics, they also mediate most procarcinogens oxidat...
Editorial: Role of Drug Metabolism and its Mediated DDI in Drug Efficacy and Safety Part 2 [0.03%]
述评：药物代谢及介导的药物相互作用在药效和安全性中的作用（二）
Changxiao Liu,Xin He
Changxiao Liu
Effects Of Glycoprotein IIb/IIIa Antagonists: Anti Platelet Aggregation And Beyond [0.03%]
糖蛋白IIb/IIIa拮抗剂的效应：抗血小板聚集及其它功效
Arturo Giordano,Giuseppe Musumeci,Anna D&#x;Angelillo et al.
Arturo Giordano et al.
Background: The use of inhibitors of glycoprotein IIb/IIIa (GPIIb/IIIa) has provided dramatic results in terms of the prevention of acute stent thrombosis and a reduction in major adverse coronary events in patients subje...
Therapeutic Potential of N-Acetylcysteine for Wound Healing, Acute Bronchiolitis, and Congenital Heart Defects [0.03%]
N-乙酰半胱氨酸在伤口愈合、急性支气管炎和先天性心脏缺陷治疗中的潜力
Manaf AlMatar,Tahira Batool,Essam A Makky
Manaf AlMatar
Background: Wound healing is a composite and vital process in which devitalized tissue layers and cellular structures repair themselves. Bronchiolitis is generally prompted by respiratory syncytial virus or human metapneu...
Occurrence, Human Intake and Biodegradation of Estrogen-Like Nonylphenols and Octylphenols [0.03%]
壬基酚和辛基酚的赋存、人体暴露及生物降解性研究进展
Shir-Ly Huang,Nguyen Ngoc Tuan,Kyoung Lee
Shir-Ly Huang
Background: Long-chain alkylphenols, such as nonylphenols and octylphenols, are man-made compounds with estrogen-like activity and considered to be endocrine disputing chemicals. They are known to influence sexual develop...
Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection [0.03%]
_indole-3-甲基碳二亚胺（i3c）及其主要衍生物：它们的药代动力学和重要的肝脏保护作用_
Si-qi Wang,Li-sha Cheng,Yun Liu et al.
Si-qi Wang et al.
Background: Indoles, including indole-3-carbinol (I3C) and its derivatives, are the products of glucosinolate hydrolysis catalyzed by the enzyme myrosinase. Under acidic conditions, I3C polymerizes into 3, 3- diindolylmet...
Optimizing DMPK Properties: Experiences from a Big Pharma DMPK Department [0.03%]
优化药物代谢动力学性质：大型制药公司药代动力部门的经验教训
Anna-Karin Sohlenius-Sternbeck,Juliette Janson,Johan Bylund et al.
Anna-Karin Sohlenius-Sternbeck et al.
Background: The disposition of a drug is dependent on interactions between the body and the drug, its molecular properties and the physical and biological barriers presented in the body. In order for a drug to have a desi...