A Systematic Review of Pharmacokinetic Models of Vancomycin in Adult Patients (2020-2024): Trends, Variability, and Key Covariates [0.03%]
2020-2024年成人患者万古霉素药动学模型的系统评价：趋势、变异性和关键协变量
Raquel Fresquet-Molina,María de Los Ángeles Allende-Bandres,Mercedes Arenere-Mendoza et al.
Raquel Fresquet-Molina et al.
Introduction: This systematic review aimed to identify, evaluate, and critically an-alyze pharmacokinetic models of vancomycin in adult populations published in PubMed and EMBASE between 2020 and 2024. ...
Annu Bhati,Avijit Mazumder,Priyanka Bansal et al.
Annu Bhati et al.
Drug-induced hepatotoxicity (DIH) poses a significant clinical challenge due to its unpredicta-ble nature and diverse manifestations. The liver, with its central role in metabolism and close association with the gastrointestinal tract, is p...
Lung-Targeting Cepharanthine Polymer Micelles Modified with Mannose: Effectiveness Against Acute Lung Injury Evaluated Using in vitro and in vivo Analyses [0.03%]
甘露糖修饰的长春胺聚合物胶束的肺靶向性：体内外分析评估其对急性肺损伤的有效性
Rui Xue,Yi-Ying Chen,Jia-Hua Mei et al.
Rui Xue et al.
Introduction: The currently available therapies for acute lung injury (ALI), including gluco-corticoids, protease inhibitors, and heparin, have limited clinical efficacy and are often associated with significant side effects. Cepharanthine ...
Applications of Proteomics, Glycomics, and Metabolomics Analyses in Systemic Lupus Erythematosus [0.03%]
蛋白质组、糖蛋白组和代谢组分析在系统性红斑狼疮中的应用
Rui Xu,Guosong Zhang,Shifang Wang et al.
Rui Xu et al.
Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disorder in-fluenced by genetic predisposition, immune dysregulation, environmental triggers, and epi-genetic modifications. Despite advances in treatment, many patients expe...
Smart Stimuli-Responsive Drug Delivery Systems for Advanced Diabetes Management [0.03%]
用于高级糖尿病管理的智能刺激响应型药物递送系统
Km Preeti Jaiswal,Monika,Rupa Mazumder et al.
Km Preeti Jaiswal et al.
Traditional treatment methods for the management of diabetes, such as oral hypoglycemic med-ications and insulin injections, include drawbacks like systemic adverse effects, inconsistent medication levels, and low compliance. To avoid diffi...
Study on the Mechanism of Anti-Cerebral Ischemia-Reperfusion Injury of Ai Pian Based on Network Pharmacology and Metabolomics [0.03%]
基于网络药理学和代谢组学的艾片抗脑缺血再灌注损伤机制研究
Jianing Lian,Yilun Ma,Dazhong Lu et al.
Jianing Lian et al.
Objective: The objective of this study was to investigate the mechanism of anti-cerebral ischemia-reperfusion injury (anti-CIRI) of Ai pian by using the network pharmacology approach combined with serum metabolomics techn...
A Population Pharmacokinetics Model of Busulfan in Pediatric Patients with Thalas-semia Major [0.03%]
儿童重型β-地中海贫血患者环磷酰胺群体药代动力学模型
Fangyuan Lai,Dongwei Cui,Yue Li et al.
Fangyuan Lai et al.
Purpose: This research aimed to establish a population pharmacokinetic (PPK) model for busulfan (Bu) in Chinese pediatric patients with thalassemia major. We analyzed pharmacokinetic (PK) parameter variability and explored potential covaria...
Pharmacokinetics of Trelagliptin in Rats after Exposure to Acute and Chronic High Altitude Hypoxia [0.03%]
暴露于急性及慢性高海拔缺氧对大鼠体内特拉格列汀药代动力学的影响
Zhilan Huan,Delong Duo,Ni Zhao et al.
Zhilan Huan et al.
Objectives: As a long-acting DPP-4 inhibitor administered orally once a week, trelagliptin can address the issues of frequent medication and poor compliance associated with traditional hypoglycemic drugs. Revealing the pharmacokinetic chang...
Mass Balance and Metabolic Profiling of Avacopan, a Selective C5a Receptor 1 Antagonist, in Healthy Humans [0.03%]
人用选择性C5a受体1拮抗剂Avacopan的质量平衡和代谢产物分析
Yang Song,Shichang Miao,Ruiping Zhao et al.
Yang Song et al.
Introduction: Avacopan (Tavneos®) is approved as an oral adjunctive treatment at a dose of 30 mg twice daily with food for adult patients with severe active Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangi...