Advancing MET-Aberrant NSCLC Therapy with Glumetinib: Pharmacokinetics, Efficacy, Safety, Drug Interactions, and Clinical Prospects [0.03%]
Ming Lu,Xiaoyu Yin,Zhiqing Zhang
Ming Lu
Targeting Mesenchymal-Epithelial Transition Factor (MET) gene aberrations has emerged as a pivotal strategy in the precision treatment of Non-Small Cell Lung Cancer (NSCLC). Among these, MET exon 14 (METex14) skipping mutation represents a ...
Mobilising Computational Strategies in Enzyme Inhibition: Reconciling Therapeutic Innovation and Environmental Integrity from Molecular Targets to Ecosystem Disruptors [0.03%]
Mallamma T,Jeevan Gowda,Rumaan M et al.
Mallamma T et al.
Enzyme inhibition has become a cornerstone of modern therapeutics, targeting key molecular pathways implicated in cancer, metabolic disorders, and infectious diseases. This review explores diverse strategies of enzyme inhibition from classi...
Formulation and Characterization of CCD-based Optimized Geraniol-loaded Antidiabetic Niosomes [0.03%]
Nitesh Kumar Yadav,Rupa Mazumder,Anjna Rani et al.
Nitesh Kumar Yadav et al.
Introduction: Type 2 Diabetes (T2D) presents a significant global health challenge, characterized by persistent hyperglycemia and insulin resistance, with effective long-term glycemic control remaining a critical unmet ne...
Network Pharmacology and Metabolomics to Uncover the Multi-Target Anti-Non-Small Cell Lung Cancer Mechanism of Baicalin Mediated by Purine Metabolism [0.03%]
网络药理学与代谢组学揭秘黄芩素多靶抗非小细胞肺癌的作用机制：嘌呤代谢为枢纽
Jing Liao,Rui Wang,Yanan Bie et al.
Jing Liao et al.
Objective: Baicalin (BA), the primary active component of Scutellaria baicalensis, exhibits anti-tumor potential; however, its multi-target mechanism in the treatment of non-small cell lung cancer (NSCLC) remains poorly u...
Absorption, Distribution, Metabolism, and Excretion of [14C]MT-8, A Derivative of Procyanidin B3 in Sprague-Dawley Rats [0.03%]
大鼠[14C]MT-8（procyanidin B3衍生物）的吸收、分布、代谢及排泄研究
Haibo Xu,Zhiqiang Li,Linwei Wang et al.
Haibo Xu et al.
Introduction/objectives: Procyanidins are abundant dietary flavonoids with diverse pharmacological activities; however, their Absorption, Distribution, Metabolism, and Excretion (ADME) remain incompletely characterized. M...
Constant-Speed Intravenous Infusion Model Determines Pharmacokinetic Parameters: Phylloquinone as an Example [0.03%]
恒速静脉滴注模型确定药动学参数：磷脂醌为例
Yan-Ni Mi,Ping-Ping Yan,Zhi-Jian Fang et al.
Yan-Ni Mi et al.
Introduction: Reported pharmacokinetic parameters, particularly half-life (t1/2), show substantial variability for phylloquinone, due to the limitations of classical pharmacokinetic models. The study aims to determine the...
Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production [0.03%]
虫草菌丝 strain 评估及其功能活性化合物生产的多代稳定性研究
Do Thi Gam,Truong Ngoc Minh,Nguyen Khac Hung et al.
Do Thi Gam et al.
Background: Cordyceps militaris is a medicinal fungus known for producing bioactive compounds, including cordycepin, adenosine, and polysaccharides, that exhibit antioxidant, immunomodulatory, and anticancer properties. E...
Emerging Nanoformulation-Based Carrier Systems: New Insights into Promising Vaccine Delivery [0.03%]
基于纳米递药系统的疫苗传输新见解
Kuldeep Rajpoot
Kuldeep Rajpoot
Introduction: Vaccines are crucial for controlling infectious diseases and reducing reliance on antibiotics, yet many diseases still lack effective vaccines. Advances in nanomaterials engineering offer new opportunities f...
In Vitro Drug-Drug Interactions between Oxycodone and Commonly Co-Consumed Drugs in Rat and Human Liver Microsomes [0.03%]
体外药物相互作用：盐酸羟考酮与临床联合使用高风险药物在人和大鼠肝微粒体中的相互作用研究
Weilong Gu,Rachel F Tyndale
Weilong Gu
Introduction: Oxycodone is frequently co-consumed with xylazine, etizolam, di-azepam, and methamphetamine during clinical and/or illicit use. Methods: ...
Protective Role of Atriplex halimus L. Against Sodium Benzoate-Induced Fat Benzene Accumulation, Bone Marrow and Liver Alterations in Wistar Rats [0.03%]
Atriplex halimus L. 对苯甲酸钠致Wister大鼠脂肪 benzene 积累及骨髓、肝脏损伤的保护作用
Khaoula Zeghib,Djahra Ali Boutlelis,Ibtissam Laib et al.
Khaoula Zeghib et al.
Introduction/objective: This study evaluates the adverse effects of sodium benzoate on the bone marrow and liver of rats, its potential to form benzene, and the protective role of Atriplex halimus extract. ...