Gianluca Ianiro,Silvia Pecere,Valentina Giorgio et al.
Gianluca Ianiro et al.
Background: Digestive enzymes are able to break down proteins and carbohydrates and lipids, and their supplementation may play a role in the management of digestive disorders, from lactose intolerance to cystic fibrosis. ...
Magisetty Obulesu,Magisetty Jhansilakshmi
Magisetty Obulesu
Background: Alzheimer's disease (AD) is a devastative neurodegenerative disorder with a complex etiology. Despite numerous novel nanotechnology methods targeted against cancer and neurodegenerative diseases such as AD in ...
Preventive and Therapeutic Effects of the Retinoid X Receptor Agonist Bexarotene on Tumors [0.03%]
雷诺昔酮对肿瘤的预防和治疗作用
Lisi Qi,Yuanyuan Guo,Pei Zhang et al.
Lisi Qi et al.
We present a review of recent investigations of anticancer drug bexarotene in this article. As one of the novel synthetic analogs of retinoids, bexarotene selectively binds to and activates the retinoid X receptor (RXRs) subfamilies, exerti...
Ricardo Jorge Dinis-Oliveira
Ricardo Jorge Dinis-Oliveira
Background: It is well known that ethanol can cause significant morbidity and mortality, and much of the related toxic effects can be explained by its metabolic profile. ...
Application of Model-Based Approaches to Evaluate Hepatic Transporter-Mediated Drug Clearance: In vitro, In vivo, and In vitro-In vivo Extrapolation [0.03%]
基于模型的方法在评估肝脏转运蛋白介导的药物清除中的应用：从体外到体内和从体外预测体内
Zhihao Liu,Kexin Liu
Zhihao Liu
Background: Hepatic transporters, including efflux transporters and uptake transporters, have been recognized to play an important role in the disposition of various drugs. These membrane transporters show extensive subst...
Baokun He,Zheng Chen
Baokun He
Background: Circadian clocks are endogenous timing systems that regulate various aspects of mammalian metabolism, physiology and behavior. Traditional chronotherapy refers to the administration of drugs in a defined circa...
Investigating ABCB1-Mediated Drug-Drug Interactions: Considerations for In vitro and In vivo Assay Design [0.03%]
ABCB1介导的药物相互作用研究：体内外试验设计考量
Zsolt Sáfár,Balázs Vaskó,Tasha K Ritchie et al.
Zsolt Sáfár et al.
Background: ABCB1 is a key ABC efflux transporter modulating the pharmacokinetics of a large percentage of drugs. ABCB1 is also a site of transporter mediated drug-drug interactions (tDDI). It is the transporter most freq...
Distribution and Biological Effects of Nanoparticles in the Reproductive System [0.03%]
纳米颗粒在生殖系统中的分布及其生物效应
Ying Liu,Hongxia Li,Kai Xiao
Ying Liu
Background: Nanoparticles have shown great potential in biomedical applications such as imaging probes and drug delivery. However, the increasing use of nanoparticles has raised concerns about their adverse effects on hum...
Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism [0.03%]
中枢神经系统的脑老化和疾病：犬尿酸类物质与药物代谢
Nóra Török,Zsófia Majláth,Ferenc Fülöp et al.
Nóra Török et al.
Introduction: The kynurenine pathway includes several neuroactive compounds, including kynurenic acid, picolinic acid, 3-hydroxykynurenine and quinolinic acid. The enzymatic cascade of the kynurenine pathway is tightly co...
Doriana Fruci,William C S Cho,Valerio Nobili et al.
Doriana Fruci et al.
Solid tumors account for approximately 30% of all childhood cancers. Although chemotherapy has largely contributed to strongly improve the outcome of children with cancer, multidrug resistance (MDR) remains a major mechanism limiting the ov...