Innovative Nanoscale Drug Delivery Strategies for Breast Carcinoma: A Comprehensive Exploration [0.03%]
乳腺癌纳米药物输送策略的全面探究
S Jaishree,Selvaraj Kousalya,S Prakash et al.
S Jaishree et al.
Breast cancer (BC) is one of the major causes of poor health in women and the most devastating disease after lung cancer. The term "cancer" refers to a collection of problems resulting from abnormal cell proliferation, particularly cells th...
Carboxylesterase 1-Based Drug-Drug Interaction Potential of Remimazolam: In-Vitro Studies and Literature Review [0.03%]
雷米唑胺与药物相互作用的体外研究及文献回顾基于羧酸酯酶1的雷米唑胺药物间相互作用潜能：体外研究和文献综述
Karl-Uwe Petersen,Wolfgang Schmalix,Marija Pesic et al.
Karl-Uwe Petersen et al.
Background: The ultra-short-acting benzodiazepine remimazolam, approved for procedural sedation and general anesthesia, is inactivated by carboxylesterase 1 (CES1). ...
Effects of High-altitude Hypoxia on Drug Metabolism and Pharmacokinetics of Sedative-hypnotic Drugs and Regulatory Mechanism [0.03%]
高原低氧对镇静催眠药物代谢与药动学影响及调控机制研究
Lu Tian,Guiqin Liu,Junjun Han et al.
Lu Tian et al.
Sedative hypnotics effectively improve sleep quality under high-altitude hypoxia by reducing central nervous system excitability. High-altitude hypoxia causes sleep disorders and modifies the metabolism and mechanisms of drug action, impact...
Prediction of Protein-Drug Interactions, Pharmacophore Modeling, and Toxicokinetics of Novel Leads for Type 2 Diabetes Treatment [0.03%]
用于2型糖尿病治疗的新型先导化合物的蛋白质-药物相互作用预测、药效团建模及毒代动力学研究
Anuradha Mehra,Amit Mittal,Prakhar Kumar Vishwakarma
Anuradha Mehra
Background: Small heterocyclic compounds have been crucial in pioneering advances in type 2 diabetes treatment. There has been a dramatic increase in the pharmacological development of novel heterocyclic derivatives aimed...
Role of P-glycoprotein in Regulating the Efficacy, Toxicity and Pharmacokinetics of Yunaconitine [0.03%]
P-糖蛋白在乌头碱疗效、毒性和药代动力学中的作用研究进展
Xiaocui Li,Qi Liang,Caiyan Wang et al.
Xiaocui Li et al.
Background: Yunaconitine (YAC) is a hidden toxin that greatly threatens the life safety of patients who are prescribed herbal medicines containing Aconitum species; however, its underlying mechanism remains unclear. ...
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats [0.03%]
一种高效的整合策略：评估菲律宾海漆树中樱草皂苷的全面代谢产物谱定性分析策略及定量优化方法研究
Xiangying Wang,Xiao Yang,Erwei Hao et al.
Xiangying Wang et al.
Objective: Sakurasosaponin, a primary bioactive saponin from Aegiceras corniculatum, shows potential as an anti-cancer agent. However, there is a lack of information on its in vivo metabolism. This study aims to profile t...
Study on Cytochrome P450 Metabolic Profile of Paclitaxel on Rats using QTOF-MS [0.03%]
基于Q-TOF-MS的紫杉醇大鼠体内Ⅰ相代谢产物研究
Zhaoyang Meng,Junjun Chen,Lingyan Xu et al.
Zhaoyang Meng et al.
Background: Paclitaxel (PTX) is a key drug used for chemotherapy for various cancers. The hydroxylation metabolites of paclitaxel are different between humans and rats. Currently, there is little information available on ...
UPLC-LTQ-Orbitrap Study on Rat Urinary Metabolites of 5-Methoxy-Alpha-Methyltryptamine [0.03%]
超高效液相色谱-线性离子阱轨道四级质谱法研究5-甲氧基-α-甲基色胺在大鼠尿中的代谢产物
Guo Zhutao,Keran Ding,Shuiqing Zheng et al.
Guo Zhutao et al.
Objective: 5-Methoxy-α-Methyltryptamine (5-MeO-AMT) is a new psychoactive substance which is abused due to its hallucinogenic and euphoric effects. This study aimed to study the metabolic characteristics of 5-MeO-AMT. ...
Isopsoralen Improves Glucocorticoid-induced Osteoporosis by Regulating Purine Metabolism and Promoting cGMP/PKG Pathway-mediated Osteoblast Differentiation [0.03%]
异补骨素通过调节嘌呤代谢和促进一氧化氮/cGMP/PKG信号通路介导的成骨分化改善糖皮质激素诱导的骨质疏松症
Defeng Liu,Lingyun Ma,Jihui Zheng et al.
Defeng Liu et al.
Background: The effects of Isopsoralen (ISO) in promoting osteoblast differentiation and inhibiting osteoclast formation are well-established, but the mechanism underlying ISO's improvement of Glucocorticoid- Induced Oste...
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities [0.03%]
细胞色素P450 3A4在肿瘤耐药中的作用：挑战与机遇
Swaroop Kumar Pandey,Sona Verma,Shobha Upreti et al.
Swaroop Kumar Pandey et al.
One of the biggest obstacles to the treatment of diseases, particularly serious conditions like cancer, is therapeutic resistance. The process of drug resistance is influenced by a number of important variables, including MDR genes, drug ef...