Stereoselective Pharmacodynamics and Pharmacokinetics of Proton Pump Inhibitors [0.03%]
质子泵抑制剂的立体选择性药理学及药物代谢动力学
Zhi-Cheng Yang,Feng Yu,Yong-Qing Wang et al.
Zhi-Cheng Yang et al.
Proton pump inhibitors (PPIs) are a group of gastric acid suppressing drugs, that are strong and long-lasting inhibitors of the proton pump (referred to as acid pump antagonists). They work by irreversibly blocking the H+/K+ ATPase. PPIs ar...
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies [0.03%]
糖尿病代谢产物甲基乙二醛与胰岛素抵抗、血管功能障碍及神经病变有关
Yousif A Shamsaldeen,Louise S Mackenzie,Lisa A Lione et al.
Yousif A Shamsaldeen et al.
Background: Diabetes mellitus (DM) is a pandemic metabolic disease characterized by a chronically elevated blood glucose concentration (hyperglycemia) due to insulin dysfunction. Approximately 50% of diabetics show diabet...
Can Dietary Polyphenols Prevent the Formation of Toxic Compounds from Maillard Reaction? [0.03%]
饮食多酚能预防美拉德反应毒害物质的生成吗？
Serena Del Turco,Giuseppina Basta
Serena Del Turco
Background: Polyphenols are functional compounds in edible vegetable and food such as tea, coffee and red wine and increasing evidence demonstrates a positive link between consumption of polyphenol-rich foods and disease ...
Thiopurine Biotransformation and Pharmacological Effects: Contribution of Oxidative Stress [0.03%]
硫嘌呤生物转化和药理作用：氧化应激的贡献
Marco Pelin,Sara De Iudicibus,Margherita Londero et al.
Marco Pelin et al.
Background: Thiopurine antimetabolites are important agents for the treatment of severe diseases, such as acute lymphoblastic leukemia and inflammatory bowel disease. Their pharmacological actions depend on biotransformat...
Emerging Potential of Natural Products as an Alternative Strategy to Pharmacological Agents Used Against Metabolic Disorders [0.03%]
天然产物作为代谢性疾病药物替代策略的潜在作用力
Tânia R Dias,Raquel L Bernardino,Maria J Meneses et al.
Tânia R Dias et al.
Background: Human metabolism is an essential biological process that involves the consumption of different substrates to ensure the nutritional and energetic needs of cells. The disruption of this highly regulated system ...
Sulfotransferase 1A1 as a Biomarker for Susceptibility to Carcinogenesis: From Molecular Genetics to the Role of Dietary Flavonoids [0.03%]
磺基转移酶1A1作为致癌易感性的生物标志物：从分子遗传学到膳食黄酮的作用
Katrin Sak,Hele Everaus
Katrin Sak
Background: Sulfotransferase (SULT) 1A1 is a phase II metabolic enzyme that catalyzes sulfate conjugation of various phenolic compounds, including endogenous substances, such as estrogens and thyroid hormones, but also di...
Alessandra Bitto,Giovanni Pallio,Sonia Messina et al.
Alessandra Bitto et al.
Background: Statins are inhibitors of hydroxy-methyl-glutaryl coenzymeA (HMG-CoA) reductase, the rate-limiting enzyme involved in de novo cholesterol synthesis. The patient health profile needs to be taken in account duri...
A Comparison of Non-Human Primate Cytochrome P450 2D Members and the Implication in Drug Discovery [0.03%]
非人灵长类动物CYP2D成员的比较及其在药物研发中的意义
Zhi-Xu He,Xiao-Wu Chen,Yinxue Yang et al.
Zhi-Xu He et al.
Background: Non-human primates are valuable animal models in drug discovery and biomedical research. Human CYP2D6 accounts for 1.3-4.3% of total hepatic CYP content in the liver, but is involved in the metabolism of more ...
Laura Rivoli,Francesca Di Mario,Giuseppe Coppolino et al.
Laura Rivoli et al.
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the...
Therapeutic microRNA Delivery Strategies with Special Emphasis on Cancer Therapy and Tumorigenesis: Current Trends and Future Challenges [0.03%]
治疗性微小核糖核酸递送策略特别注重癌症疗法和肿瘤发生机制：当前趋势与未来挑战
Chiranjib Chakraborty,Zhi-Hong Wen,Govindasamy Agoramoorthy et al.
Chiranjib Chakraborty et al.
Background: Over the decade, miRNAs are the most important molecules for the biopharmaceutical industry due to their relation with several human diseases. Presently, the phase-II clinical trial has been initiated for the ...