Drug Interactions with Angiotensin Receptor Blockers: Role of Human Cytochromes P450 [0.03%]
血管紧张素受体拮抗剂的药物相互作用：人类细胞色素P450的作用
Ruirui Yang,Zhiqiang Luo,Yang Liu et al.
Ruirui Yang et al.
Background: Angiotensin receptor blockers (ARBs) are the most recent class of agents for the treatment of hypertension. However, ARBs may cause a low incidence of headache, upper respiratory infection, back pain, muscle c...
Population Pharmacokinetics of Phenytoin Based on NONMEM in Patients with Intracranial Tumor During the First Week of Post-Craniotomy [0.03%]
基于NONMEM的颅脑手术后一周内颅内肿瘤患者苯妥英群体药代动力学参数研究
Zhong-Dong Li,Meng Liu,Liang Li et al.
Zhong-Dong Li et al.
Background: It was reported that phenytoin can prevent early post traumatic seizures. The present study aims to establish a population pharmacokinetic (PPK) model of oral phenytoin in patients with intracranial tumor duri...
Clinical Trial
Current drug metabolism. 2016;17(7):721-8. DOI:10.2174/1389200217666160513132716 2016
Improved Prediction of Michaelis Constants in CYP450-Mediated Reactions by Resilient Back Propagation Algorithm [0.03%]
利用弹性反向传播算法改进CYP450介导反应中Michaelis常数的预测能力
Hao Dai,Qin Xu,Yi Xiong et al.
Hao Dai et al.
Background: In drug metabolism reactions, it has become increasingly important to measure Michaelis constants (Km), which are used for a variety of purposes, including identification of enzymes involved in drug metabolism...
Strategies for the Assessment of Metabolic Profiles of Steroid Hormones in View of Diagnostics and Drug Monitoring: Analytical Problems and Challenges [0.03%]
代谢组学中针对诊断和药物浓度监测的甾体激素代谢谱分析策略：分析问题与挑战
Alina Plenis,Ilona Oledzka,Piotr Kowalski et al.
Alina Plenis et al.
Background: During the last few years there has been a growing interest in research focused on the metabolism of steroid hormones despite that the study of metabolic hormone pathways is still a difficult and demanding tas...
Sergio Fusco,Sabrina Garasto,Andrea Corsonello et al.
Sergio Fusco et al.
Objective: To summarize current evidence about mechanisms, clinical features, diagnostic issues, and strategies for prevention of medication-induced nephrotoxicity among older people. ...
Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs [0.03%]
鼻上皮中的药物代谢酶和外排转运体对鼻给药生物利用度的影响
Paula Oliveira,Ana Fortuna,Gilberto Alves et al.
Paula Oliveira et al.
Background: The interest in administering drugs by intranasal route is currently increasing, particularly because it has shown to ensure drug therapeutic action by a rapid systemic absorption through the respiratory mucos...
Parkinson's Disease: Recent Updates in the Identification of Human Dopa Decarboxylase Inhibitors [0.03%]
帕金森病：人类多巴脱羧酶抑制剂鉴定的最新进展
Riccardo Montioli,Carla B Voltattorni,Mariarita Bertoldi
Riccardo Montioli
Backround: Parkinson's disease is a pathology involving the progressive degeneration of dopaminergic neurons in the substantia nigra of the brain. L-DOPA combined with an inhibitor of DOPA decarboxylase, a pyridoxal 5'-phosphate-dependent e...
Diabetic Nephropathy: Focus on Current and Future Therapeutic Strategies [0.03%]
糖尿病肾病当前及未来的治疗策略:focus on Diabetic Nephropathy
Riccardo Pofi,Francesca Di Mario,Antonietta Gigante et al.
Riccardo Pofi et al.
Background: Diabetic nephropathy (DN) is currently the most common cause of end-stage renal disease (ESRD). Although nowadays much is known about its classification, pathogenesis, clinical manifestations and evolution, to...
Alberto Verrotti,Elisabetta Mencaroni,Marta Cofini et al.
Alberto Verrotti et al.
Background: Valproic acid (VPA) is a broad spectrum antiepileptic drug (AED) that is generally regarded as a first-choice agent for most forms of idiopathic and symptomatic generalised epilepsies. Available data suggest t...
Constanza Morén,Diana Luz Juárez-Flores,Francesc Cardellach et al.
Constanza Morén et al.
Background: Certain therapeutic drugs used in medical practice may trigger mitochondrial toxicity leading to a wide range of clinical symptoms including deafness, neuropathy, myopathy, hyperlactatemia, lactic acidosis, pa...