Huile Gao
Huile Gao
Background: Tumor microenvironment is so complex that involves in many factors of tumor. Although enhanced permeability and retention effect is a main driving force of tumor targeted nanoparticles, the tumor microenvironm...
P-gp Inhibition-Based Strategies for Modulating Pharmacokinetics of Anticancer Drugs: An Update [0.03%]
基于P-糖蛋白抑制的抗癌药物药代动力学调控策略最新研究进展
Xiaobo Yang,Kexin Liu
Xiaobo Yang
Background: P-glycoprotein (P-gp), a well known ATP dependent efflux membrane transporter, has been attracting considerable interests of medical researchers due to its efflux pump effect being a primary cause of multidrug...
Urszula Kolakowska,Witold Olanski,Anna Wasilewska
Urszula Kolakowska
The salusins are bioactive peptides with hemodynamic effects. They play a role in hypertension, atherogenesis and cardiovascular diseases. In this review we focus on new actions, which are related to the regulation of blood pressure. Decrea...
Wen Jin Hua,Wei Xiao Hua,Zhou Jian et al.
Wen Jin Hua et al.
Background: Various transporters, including efflux transporters and uptake transporters, play an important role in the pharmacokinetics of drugs. Currently, studies suggest that several antibiotics also serve as substrate...
Factors Affecting the Pharmacokinetics, Biodistribution and Toxicity of Gold Nanoparticles in Drug Delivery [0.03%]
影响药物递送中金纳米颗粒药代动力学、生物分布和毒性的因素
Qiyue Xia,Hongxia Li,Kai Xiao
Qiyue Xia
Owing to the straightforward synthesis, good biological compatibility, and ease of surface functionalization, gold nanoparticles (AuNPs) have shown great potential in various biomedical applications, including diagnostic imaging, phototherm...
Ye Bi,Fei Hao,Guodong Yan et al.
Ye Bi et al.
Background: Nanomedicine is an emerging therapeutic modality. Nanoparticles (NPs) are potential vehicles for delivery of anticancer therapeutics. NPs can be designed to facilitate tumor drug delivery both by passive and a...
The recent development of nanoparticles for brain tumor targeting delivery [0.03%]
针对脑肿瘤靶向输送的纳米颗粒最近的研究进展
Maxim A Shevtsov
Maxim A Shevtsov
Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted a lot of interest due to their widespread diagnostic and therapeutic applications in neuro-oncology. Functinalization of the particles surface with targeting molecules that ...
Recent Developments of Magnetic Nanoparticles for Theranostics of Brain Tumor [0.03%]
用于脑肿瘤诊疗的磁性纳米颗粒最新研究进展
Maxim Shevtsov,Gabriele Multhoff
Maxim Shevtsov
Background: Glioblastoma multiforme, one of the most aggressive brain tumors, has a very poor clinical outcome. Despite the introduction of the alkylating reagent temozolomide (TMZ) to surgery and radiotherapy, the surviv...
Influence of Tumor Microenvironment on the Distribution and Elimination of Nano-formulations [0.03%]
肿瘤微环境对纳米药物分布和消除的影响
Birendra Chaurasiya,Arpan Mahanty,Debmalya Roy et al.
Birendra Chaurasiya et al.
Objective: To give an in-depth overview about the tumor and its surrounding microenvironment influencing distribution and elimination of nanoformulations. Mehtods: This up-to-date review will summarize the microenvironmen...
Osama Y Alshogran,Thomas D Nolin
Osama Y Alshogran
Chronic kidney disease (CKD) modulates the nonrenal clearance of drugs by altering their metabolism and/or transport. While the effects of CKD on pathways of oxidative and conjugative metabolism in the liver are generally understood, the im...