Ceftobiprole and Cefiderocol for Patients on Extracorporeal Membrane Oxygenation: The Role of Therapeutic Drug Monitoring [0.03%]
替托溴铵和伊代雷odoxol用于体外膜氧合患者的作用：治疗药物监测的作用
Diana Morales Castro,John Granton,Eddy Fan
Diana Morales Castro
Introduction: Limited data exist on therapeutic ranges for newer antimicrobials in the critically ill, with few pharmacokinetic studies including patients undergoing renal replacement therapy or extracorporeal membrane ox...
Development of Hot Melt Extruded Co-Formulated Artesunate and Amodiaquine- Soluplus® Solid Dispersion System in Fixed-Dose Form: Amorphous State Characterization and Pharmacokinetic Evaluation [0.03%]
用于固定剂量制剂的热熔挤出阿莫地喹和 Arteunate-Soluplus 固体分散系统制备：无定形状态表征与药动学评估
Md Ali Mujtaba,Ritesh Fule,Purnima Amin et al.
Md Ali Mujtaba et al.
Introduction: This study aims to develop co-amorphous Solid Dispersion (SD) system containing antimalarials Artesunate (ARS) and Amodiaquine (AMQ) to improve its oral bioavailability employing the Hot Melt Extrusion (HME)...
Quality by Design-Steered Development of Stealth Liposomal Formulation of Everolimus: A Systematic Optimization and Evaluation [0.03%]
基于质量的设计引导的依维莫司长效缓释脂质体 stealth 性能研究及评价
Simranjeet Kaur,Rajveer Singh,Dilpreet Singh
Simranjeet Kaur
Background: Everolimus is a drug approved for the treatment of breast cancer with HR+ and advanced breast cancer reoccurring in postmenopausal women. The oral administration of EVE has been observed to have low oral bioav...
Metabolic Stability and Metabolite Identification of CYP450 Probe Substrates in Ferret Hepatocytes [0.03%]
雪貂肝细胞中的CYP450探针底物的代谢稳定性及其代谢产物鉴定
Jiang Pu,Wanyong Feng
Jiang Pu
Background: Ferrets exhibit similar lung physiology to humans and display similar clinical signs following influenza infection, making them a valuable model for studying high susceptibility and infection patterns. However...
Metabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control [0.03%]
基于高分辨率质谱特征的马尿中奥昔洛德STAT代谢途径建立的研究论文标题
Hideaki Ishii,Ryo Shigematsu,Shunsuke Takemoto et al.
Hideaki Ishii et al.
Objective: Osilodrostat, used to treat Cushing's disease, exhibits an anabolic effect, leading to its classification as a prohibited substance in horseracing and equestrian sports. This study reports the characterization ...
Biomimetic Nanoscale Systems for Targeted Delivery in Cancer: Current Advances and Future Prospects [0.03%]
癌症靶向递送的仿生纳米系统：研究进展与未来展望
Dilpreet Singh,Neelam Poonia
Dilpreet Singh
The field of cancer therapy has witnessed a transformative shift with the emergence of biomimetic nanoscale drug delivery systems. These innovative platforms draw inspiration from nature's intricate designs and have the potential to revolut...
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats [0.03%]
盐酸沙丁胺醇对大鼠肺及血浆中左氧氟沙星药动学影响的研究
Murat Ali Cicekler,Halis Oguz,Orhan Corum
Murat Ali Cicekler
Background: Antibiotics and bronchodilator drugs can be used together in respiratory distress caused by bacterial infections. Levofloxacin (LVX) and Salbutamol (SLB) can be used simultaneously in respiratory distress. How...
A Cross-sectional Comparative Analysis of Eleven Population Pharmacokinetic Models for Docetaxel in Chinese Breast Cancer Patients [0.03%]
中国乳腺癌患者多西他赛人群药代动力学模型的横断面比较分析
Genzhu Wang,Qiang Sun,Xiaojing Li et al.
Genzhu Wang et al.
Objective: Various population pharmacokinetic (PPK) models have been established to help determine the appropriate dosage of docetaxel, however, no clear consensus on optimal dosing has been achieved. The purpose of this ...
Comparative Study
Current drug metabolism. 2024;25(7):479-488. DOI:10.2174/0113892002322494240816032948 2024
Hepatic Metabolic Enzyme Activity with Endogenous Substances-Current Status, Challenges and Limitations [0.03%]
内源性物质的肝代谢酶活性研究—现状、挑战与局限性
Wen Kou,Xinan Wu
Wen Kou
Precision dosing is essential in improving drug efficacy and minimizing adverse reactions, especially in liver impaired patients. However, there is no objective index to directly evaluate the body's ability to metabolize specific drugs. Man...
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis [0.03%]
氢 Peroxide 通过 NF-KB 经典途径诱导乙醇诱导的 CYP2E1：CYP2E1 mRNA 水平在酒精性肝炎中不高
Akiyoshi Tamura,Ferbian Milas Siswanto,Takumi Yoshimura et al.
Akiyoshi Tamura et al.
Aims: The aim of the present study is to elucidate the mechanism of CYP2E1 induction as a causative factor of Alcoholic Hepatitis (AH) and its relationship with inflammation. ...