Characterization of Five Natural Anthraquinone Compounds as Potent Inhibitors against CYP1B1: Implications for Cancer Treatment [0.03%]
五种天然蒽醌化合物作为CYP1B1强效抑制剂的表征及其对癌症治疗的意义
Zujia Chen,Zhixiang Xu,Xiaodong Chen et al.
Zujia Chen et al.
Background: Human cytochrome P450 1B1 (CYP1B1) is an extrahepatic enzyme that is overexpressed in many tumors and is associated with tumor development and acquired resistance. Few studies have reported that anthraquinone ...
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review [0.03%]
他克莫司、细胞色素P450、器官移植受者中的食物相互作用；最新和全面的综述
Zahra Tolou-Ghamari
Zahra Tolou-Ghamari
The well-established calcineurin inhibitor, tacrolimus, as an immunosuppressive agent, is widely prescribed after organ transplantation. Cytochrome P450 (CYP 450) isoforms are responsible for the metabolism of many features associated with ...
Venkateshwaran Krishnaswami,Kumar Janakiraman,Vaidevi Sethuraman et al.
Venkateshwaran Krishnaswami et al.
Gene silencing is the characteristic that inhibits gene expression afforded by siRNA interference. The efficacy of the delivery system in terms of precision, efficacy, and stability can be enhanced by genebased drug delivery options. The de...
Naling Fan,Teng Guo,Liying Du et al.
Naling Fan et al.
Objective: Tacrolimus, a calcineurin inhibitor (CNI), is the first-line treatment for chronic myeloid leukemia (CML) and advanced gastrointestinal stromal tumors (GIST). Imatinib and tacrolimus are both substrates of the ...
Characterizing Pharmacokinetic Variability of Topiroxostat in Chinese Population: Insights from a Phase I Randomized Clinical Trial [0.03%]
托雷西莫司在中国人中的药代动力学特征：来自Ⅰ期随机临床试验的启示
Tianqi Zhong,Kaizong Huang,LuYao Han et al.
Tianqi Zhong et al.
Objective: This Phase I clinical trial aimed to address the knowledge gap regarding topiroxostat's use outside Japan by characterizing its pharmacokinetic profile, safety, and efficacy in healthy Chinese subjects. ...
Clinical Trial
Current drug metabolism. 2024 Dec 16. DOI:10.2174/0113892002348045241210071452 2024
Clinical Pharmacology and Side Effects of Venetoclax in Hematologic Malignancies [0.03%]
维奈克拉在血液系统恶性肿瘤中的临床药理学和副作用
Yuting Yan,Yujiao Guo,Ziyi Wang et al.
Yuting Yan et al.
Venetoclax is a first-in-class B-cell lymphoma/lymphoma-2 (BCL-2) inhibitor that induces apoptosis in malignant cells through the inhibition of BCL-2. The clinical response to venetoclax exhibits heterogeneity, and its sensitivity and resis...
Application of UPLC-MS/MS to Study Cellular Pharmacokinetics of Seven Active Components of Cnidii Fructus Extracts [0.03%]
超高压液相色谱-质谱联用技术用于研究千金藤素等7种化学成分的细胞药动学行为
Yu Bai,Huizi Ouyang,Yang Liu et al.
Yu Bai et al.
Background: Cnidii Fructus (CF) is a herbal medicine with pharmacological activities such as antitumor, antiviral, antiallergic, antipruritic effects, and so on. ...
Unveiling the Interplay: Antioxidant Enzyme Polymorphisms and Oxidative Stress in Preterm Neonatal Renal and Hepatic Functions [0.03%]
抗氧化酶多态性与早产新生儿肾肝功能氧化应激的相互作用分析
Kannan Sridharan,Mona Al Jufairi
Kannan Sridharan
Aims: To explore the relationship between oxidative stress biomarkers and the occurrence of acute kidney injury (AKI) alongside notable liver function disturbances in preterm neonates. ...
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries [0.03%]
药物代谢酶：阿拉伯国家药学遗传动力学最新研究的独家指南
Laith Al Eitan,Iliya Yacoub Khair,Saif Alahmad
Laith Al Eitan
Drug metabolizing enzymes play a crucial role in the pharmacokinetics and pharmacodynamics of therapeutic drugs, influencing their efficacy and safety. This review explores the impact of genetic polymorphisms in drug-metabolizing genes on d...
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route [0.03%]
用于鼻内给药输送氯卡色林盐酸盐的脂质载药制剂的质量源于设计开发方法研究
Pallavi Chiprikar,Vinayak Mastiholimath,Prakash Biradar et al.
Pallavi Chiprikar et al.
Background: Cariprazine (CPZ) is a third-generation antipsychotic medication that has been approved for treating schizophrenia. This study aimed to develop a cariprazine-loaded nanostructured lipid carrier (CPZ-NLCs) to p...