Comparative in Vitro Metabolic Profile Study of Five Cathinone Derivatives [0.03%]
五种卡因衍生物的体外代谢谱比较研究
Zexuan Li,Sufang Xiang,Tian Zheng et al.
Zexuan Li et al.
Background: Cathinone derivatives as new psychoactive substances have attracted worldwide attention in recent years. They have strong excitatory effects on the human central nervous system, which is extremely abusive and ...
Transformative CRISPR-Cas9 Technologies: A Review of Molecular Mechanisms, Precision Editing Techniques, and Clinical Progress in Sickle Cell Disease [0.03%]
变革性的CRISPR-Cas9技术：分子机制、精准编辑技术和在镰状细胞疾病中的临床进展的回顾
Komal,Prabhjot Kaur,Nidhi Arora et al.
Komal et al.
Sickle cell disease (SCD) is a hereditary blood disorder resulting from the production of distorted hemoglobin molecules that cause red blood cells to adopt a sickle or crescent-like shape. This disease affects millions of people, particula...
Corrigendum To: Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates [0.03%]
《建立高内涵影像平台来测量LPS诱导的RAW264.7巨噬细胞中NF-κB核转位用于筛选抗炎药物候选物》的勘误表
Yan-Yu Zhang,Yun-Da Yao,Qi-Qing Cheng et al.
Yan-Yu Zhang et al.
In the article titled "Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPSinduced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates" published in Current Drug Metabolism, Volume 2...
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor [0.03%]
BPI-460372的体内外药物代谢分析 - 一种共价TEAD1/3/4抑制剂
Xiaoyun Liu,Dafang Zhong,Chong Zhuang Tang et al.
Xiaoyun Liu et al.
Background: BPI-460372 is an orally available, covalent, irreversible small molecule inhibitor of the transcriptional enhanced associate domain (TEAD) 1/3/4, which is currently in clinical development for the treatment of...
A Review on Drug-Metabolizing Enzymes, Transporters, and Gut Microbiota on Pharmacokinetics in High-Altitude Environment [0.03%]
高海拔环境下药物代谢酶、转运体和肠道微生物对药代动力学影响的研究进展
Fangfang Qiu,Yuemei Sun,Wenbin Li et al.
Fangfang Qiu et al.
The most significant feature of the high-altitude environment is hypoxia, which affects the activity and expression of drug-metabolizing enzymes and transporters, leading to changes in pharmacokinetic parameters. Notably, gut microbiota is ...
Umbelliferone Enhances Immune Function in Cyclophosphamide-Induced Immunosuppressed Mice via Histidine and Purine Metabolism Regulation [0.03%]
伞形花内酯通过组氨酸和嘌呤代谢调节增强环磷酰胺诱导的免疫抑制小鼠的免疫力
Mei Li,Jing Wang,Bingjie Huo et al.
Mei Li et al.
Background: Chemotherapy-induced immunosuppression significantly impacts patient's quality of life. Umbelliferone (UMB) is known for its anti-inflammatory, antioxidant, and anti-apoptotic properties, but its effects on cy...
Pharmacokinetic Interactions of Paxlovid Involving CYP3A Enzymes and P-gp Transporter: An Overview of Clinical Data [0.03%]
帕克斯洛维德与CYP3A酶和P-糖蛋白转运蛋白的药动学相互作用：临床数据概览
Naina Mohamed Pakkir Maideen,Krishnaveni Kandasamy,Rajkapoor Balasubramanian
Naina Mohamed Pakkir Maideen
Background: The US FDA has approved paxlovid, a combination of nirmatrelvir and ritonavir, as the first oral treatment for the management of mild-to-moderate COVID-19 patients. ...
Effects of Shenmai Injection on the Pharmacokinetics of Dasatinib: An In-Depth In vivo Analysis Utilizing UPLC-MS/MS Technique [0.03%]
参麦注射液对达沙替尼药代动力学的影响：一种深入的体内分析及UPLC-MS/MS技术的应用
Weina Ma,Ling Li,Zhihui Li et al.
Weina Ma et al.
Background: Dasatinib has been widely used in the treatment of a variety of cancers, such as lung cancer and acute myeloid leukemia. Shenmai injection is a traditional Chinese medicine injection that is often used in anti...
Hallmarks of Quercetin Benefits as a Functional Supplementary in the Management of Diabetes Mellitus-Related Maladies: From Basic to Clinical Applications [0.03%]
檞皮素作为功能性补充剂在糖尿病相关疾病管理中的益处特征：从基础到临床应用
Faegheh Farhadi,Fariba Sharififar,Mandana Jafari et al.
Faegheh Farhadi et al.
Quercetin (QE), a particular flavonoid, is well known for its medicinal effects, including anti-oxidant, hypoglycemic, and anti-inflammatory effects. In this review, the findings of QE effects on diabetes STZinduced, alloxan-induced, and it...
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study [0.03%]
探究洛沙坦与卡马西平相互作用的药代动力学和药效学研究
Shruthi A Sundargowda,Sunil Kumar Kadiri
Shruthi A Sundargowda
Background: Hypertension, which affects 1.28 billion people globally aged 30 to 79, is characterized by continuously high blood pressure (140/90 or more) and raises the risk of premature death. Losartan, an angiotensin re...