Jiayi Yin,Yuting Qi,Feng Zhu et al.
Jiayi Yin et al.
Exploring the Effects of Oxidative Stress on Female Reproductive Function: The Role of Antioxidant Supplementation [0.03%]
探讨氧化应激对女性生殖功能的影响及抗氧化补充的作用
Dala N Daraghmeh,Sawsan Salameh,Massa Zahdeh et al.
Dala N Daraghmeh et al.
Background: The female reproductive system is susceptible to oxidative stress, which can interfere with ovulation, menstrual cycles, egg quality, and tubal function, ultimately leading to infertility. Antioxidants might p...
A Gut Microbial Transformation-Integrated Network Pharmacology Approach to Elucidate the Therapeutic Mechanisms of Timosaponin AIII in Diabetes [0.03%]
基于肠道微生物转化的网络药理学方法阐释天冬皂苷AIII治疗糖尿病的作用机制研究
Yingfeng Du,Huiyi Zhang,Jinhuan Wei et al.
Yingfeng Du et al.
Objective: Timosaponin AIII, with poorly soluble characteristics, has a potential antidiabetic effect evaluated in vitro and in vivo. The major problem associated with poorly soluble drugs is very low bioavailability. Thi...
Antioxidant Potential of Gallic Acid Prevents Di-2-ethyhexyl Phthalate-induced Inhibition of Osteogenic Differentiation [0.03%]
没食子酸的抗氧化作用可预防Di-(2-乙基己基)邻苯二甲酸抑制成骨细胞分化
Abnosi Mohammad Hussein,Parvaz Mahrokh
Abnosi Mohammad Hussein
Objective: Di-2-ethylhexylphthalate (DEHP) is utilized as a plasticizer in polyvinylchloride products (PVC). When medical devices like blood bags, tubes, and syringes are employed, DEHP leaches out of the PVC polymers and...
A Data Mining Approach on Polypharmacy and Drug-drug Interactions of Common Diabetes Medications [0.03%]
大数据挖掘在糖尿病常用药物研究中的应用探讨
Jyotsana Dwivedi,Shubhi Kaushal,Pranay Wal et al.
Jyotsana Dwivedi et al.
Background: When managing diabetes, polypharmacy the use of several drugs simultaneously to obtain the best possible glucose control is typical. Drug-drug interactions (DDIs), which can result in side effects and reduced ...
Rapid and Comprehensive Identification of Vincosamide Metabolites in vitro and in vivo in Rats by Ultra-High Performance Liquid Chromatography-Quadrupole- Exactive Orbitrap-High Resolution Mass Spectrometry [0.03%]
基于UHPLC-Q-Exactive Orbitrap高分辨质谱的恩苒西胺体外及体内代谢产物的快速和全面鉴定
Aichun Gao,Hongjin Wang,Xiaoge Cheng et al.
Aichun Gao et al.
Background: Vincosamide, an indole alkaloid extracted from Nauclea officinalis, exhibits a range of pharmacological activities, such as anti-tumor, antibacterial, and anti-inflammatory properties. However, despite its pro...
Expression, Function, and Regulation of ABCG2 on the Intestinal Epithelial Barrier Permeability [0.03%]
ABCG2在肠道上皮屏障通透性的表达、功能及调节
Ping Shi,Lianhua Tang,Fei Yin et al.
Ping Shi et al.
Human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-binding cassette (ABC) efflux transporter that is highly expressed on the apical membranes of intestinal epithelium and contributes to the absorption, distribution, ...
Exploring the Gut-Brain Axis: Microbiome Contributions to Pathophysiology of Attention Deficit Hyperactivity Disorder and Potential Therapeutic Strategies [0.03%]
探究肠-脑轴：注意缺陷多动障碍的肠道菌群病理生理学贡献及潜在治疗策略
Manasi Phatak,Bhavi Nair,Urvashi Soni et al.
Manasi Phatak et al.
Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by symptoms of hyperactivity, inattention, and impulsivity, significantly impacting individuals' daily functioning and quality of life....
Prediction of Pharmacokinetics of Valeric Acid: Alternative Tool to Minimize Animal Studies [0.03%]
戊酸药代动力学的预测：减少动物研究的替代方法
Bindu Kumari,Dhananjay Kumar Singh,Ravi Bhushan Singh et al.
Bindu Kumari et al.
Background: The use of computer-aided toxicity and Pharmacokinetic (PK) prediction studies are of significant interest to pharmaceutical industries as a complementary approach to traditional experimental methods in predic...
Effect of Wuzhi Capsule (WZC) on the Pharmacokinetics of Tacrolimus in Renal Transplantation Recipients [0.03%]
五脂胶囊(WZC)对肾移植受者他克莫司药代动力学的影响
Weiyue Zhang,Ruidong Wang,Lin Li et al.
Weiyue Zhang et al.
Background: Previous studies have shown that WZC can increase tacrolimus blood concentration when co-administered. However, limited knowledge exists regarding the pharmacokinetics of both tacrolimus and the bioactive lign...