m6A Modified-CYP1B1 Promotes HCC Cell Proliferation by Inhibiting Ferroptosis [0.03%]
N6-甲基腺苷修饰的CYP1B1通过抑制铁死亡促进肝癌细胞增殖
Wenwen Huang,Haihong Hu,Sheng Cai et al.
Wenwen Huang et al.
Introduction: CYP1B1, a crucial drug-metabolizing enzyme, metabolizes both endogenous compounds and clinical drugs. The present study investigated the effects of CYP1B1 on the proliferation, migration, apoptosis, and ferr...
Influence of Orange Oil on Skin Permeability, Dermatokinetics, and In Vivo Anti-inflammatory Properties of Lornoxicam-loaded Niosomal Gel [0.03%]
橙皮油对洛硝考胺载尼奥斯微粒凝胶的皮肤通透性、药动学及抗炎作用的影响
Narahari N Palei,Arghya K Dhar,Jayaraman Rajangam et al.
Narahari N Palei et al.
Introduction: Lornoxicam is a non-steroidal anti-inflammatory drug belonging to the oxicam class. This study aimed to develop a niosomal gel containing orange oil for improving the anti-inflam-matory effect of lornoxicam....
Advancing Liposomal Drug Delivery through Physiologically-Based Pharmacokinetic Modeling [0.03%]
基于生理的药代动力学模型在脂质体药物递送中的应用
Hellen Flávia Gonçalves Braz,Gabriel Silva Marques Borges,Eduardo Burgarelli Lages
Hellen Flávia Gonçalves Braz
Moonlighting Proteins: Unveiling Their Multifunctionality in Metabolic Regulation and Drug Discovery [0.03%]
兼职蛋白：揭示其在代谢调控和药物发现中的多功能性
Shatrudhan Prajapati,Ajay Pal Singh,Namrata Bhadouria
Shatrudhan Prajapati
Moonlighting proteins, defined by their ability to perform distinct, independent functions beyond their primary roles, have garnered attention in metabolic regulation and drug discovery. This review highlights the emerging significance of t...
Oral Metronomic Formulation of Carboplatin Loaded PEGylated- MWCNTs: HPLC Method Validation and Pharmacokinetic Studies in Rabbit's Plasma [0.03%]
载有卡铂的聚乙二醇-MWCNTs口服微量给药制剂：兔血浆中的HPLC方法鉴定与药物动力学研究
Suraj Sharma,Ketousetuo Kuotsu,Sweet Naskar
Suraj Sharma
Background: Carbon nanotubes (CNTs) have emerged as promising nanocarriers in drug delivery due to their unique physicochemical properties and biocompatibility. ...
Unexpected Clinically Significant Drug-Drug Interaction between Tacrolimus and Metronidazole in the Early Period after Renal Transplantation: A Literature Review [0.03%]
他克莫司与甲硝唑在肾移植早期的临床显著性药物相互作用：文献综述
Yun Xiao,Hua Zou,Xiaoyu Han et al.
Yun Xiao et al.
Introduction: Drug interactions necessitate careful consideration in clinical practice. It is imperative for clinicians and pharmacists to monitor drug exposure and the co-administration of medications promptly in order t...
Synthesis and Antimicrobial Activity of Silver/Copper Oxide/Clay Hybrid Nanocomposites Against Gram-Positive and Gram-Negative Bacteria [0.03%]
银/铜氧化物/粘土复合纳米材料的合成及其对革兰氏阳性菌和阴性菌的抗菌性能研究
Masoud Fardin,Narges Sadr,Amirmohammad Rezvani et al.
Masoud Fardin et al.
Background: The rapid surge in bacterial resistance to classical antibiotics and antimicrobial agents has driven researchers to identify new classes of antimicrobial agents. At the nanoscale, nanotechnological progress ha...
HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations [0.03%]
高脂饮食诱导的小鼠肾小管Oatp4c1和P-糖蛋白转运系统改变：对地高辛肾脏排泄及钆增强放射影像表现的影响
Jingwen Men,Jing Li,Tianyan Zhang et al.
Jingwen Men et al.
Objective: The clearance of digoxin in obese patients with renal impairment is reduced, leading to elevated serum concentrations and increased risks of digoxin toxicity. However, the exact mechanism of such alterations in...
A Comprehensive Review on the Pharmacokinetics and Bioanalysis of Piperaquine [0.03%]
piperaquine药代动力学和生物分析的研究进展与全面回顾
Yuewu Xie,Wenting Zhang,Ziqing Rui et al.
Yuewu Xie et al.
Piperaquine is an important partner drug in artemisinin-based combination therapy, which is highly effective for the treatment of uncomplicated malaria. Several studies have been reported on its pharmacoki-netic profiles in different popula...