Application of Physiologically Based Pharmacokinetic Modeling in the Research of Anti-HIV Drugs [0.03%]
生理药代动力学模型在抗艾滋病药物研究中的应用
Yuewu Xie,Wenting Zhang,Huilong Wang et al.
Yuewu Xie et al.
Physiologically based pharmacokinetic (PBPK) modeling is a computational technique that uses the physicochemical properties of drugs and physiological information to simulate plasma and tissue concen-trations. PBPK modeling has become a mai...
Advances in Nanomedicine: Transforming Diagnostic Imaging with Novel Contrast Agents [0.03%]
纳米医学进展——新型对比剂转化诊断影像学
Priyamjeet Das,Muskan Gupta,Anwesha Sahu et al.
Priyamjeet Das et al.
In recent years, the development of medical technologies leveraging nanomedicine has witnessed remarkable progress, particularly in areas such as targeted drug delivery, controlled drug release, tissue engineering, and in vitro diagnostics....
Transcriptomic and Proteomics Analysis of a Lipid-Loaded HepaRG Model for Steatosis Reveals Altered Regulation in Lipid and Xenobiotic Metabolism [0.03%]
转录组和蛋白质组分析建立脂质负载的HepaRG模型以研究肝脂肪变性所致脂质及外源物质代谢调节改变
Anitha Saravanakumar,Cassandra A Tierney,Wen He et al.
Anitha Saravanakumar et al.
Introduction: Hepatic lipid accumulation (steatosis) is an early indicator of non-alcoholic fatty liver disease (NAFLD), preceding fibrosis and cirrhosis. Understanding its effects on drug-me-tabolizing enzymes (DMEs) and...
Mechanism of Tetrandrine in Ameliorating Hypoxic Pulmonary Hypertension Vascular Remodeling through Transcriptomics and Metabolomics [0.03%]
基于转录组和代谢组学探讨四氢怀特宁改善缺氧性肺动脉高压血管重塑的作用机制研究
Xiaowei Gong,Feitian Min,Junli Guo et al.
Xiaowei Gong et al.
Background: Tetrandrine (TET) demonstrates therapeutic potential for hypoxic pulmonary hypertension (HPH); however, its precise pharmacological mechanisms remain unclear. In this study, we aimed to investigate the effects...
Comparative Pharmacokinetics of Five Major Ingredients in Normal and Atherosclerotic Rats after Oral Administration of Shenlian Formula [0.03%]
口服参莲汤颗粒后正常大鼠和动脉粥样硬化模型大鼠五种主药效成分的药代动力学对比研究
Yan Caiying,Wang Xinge,Qin Linying et al.
Yan Caiying et al.
Introduction: Shenlian formula (SL) has been widely used to treat various diseases, including type 2 diabetes mellitus and atherosclerosis (AS). Pathological states can significantly alter drug pharmacokinetics (PK) compa...
Advances in Controlled Release Formulations for Ocular Diseases: Improving Patient Compliance and Therapeutic Outcomes [0.03%]
眼病控释制剂的研究进展：提高患者顺应性和治疗效果
Smita Narwal,Dushyant,Gurvirender Singh et al.
Smita Narwal et al.
A majority of the global population suffers from eye diseases, but few effective treatment options are available with ophthalmic drug therapies. The reasons that have been identified are (1) lack of awareness about the options for treatment...
Comprehensive Insights into Licochalcone A: its Distribution, Biosynthesis, Metabolism, and Pharmacological Effects [0.03%]
结肠腺癌肝转移小鼠模型的建立及评估标准专家共识
Xiaoxiao Wang,Jinrui Liu,Wei Li et al.
Xiaoxiao Wang et al.
Licochalcone A (LCA) is an important secondary metabolite in licorice that has attracted extensive attention due to its unique species-specific distribution characteristics and various pharmacodynamic activities, particularly its anti-infla...
Mohamed Abbas,Muneer Parayangat,Mohammad Alaa Hussain Al-Hamami et al.
Mohamed Abbas et al.
Rare diseases present unique challenges in drug discovery and development, primarily due to small patient populations, limited clinical data, and significant variability in disease mechanisms. The primary objective of this review is to exam...
Biopharmaceutical Factors Involved in the Disposition of Mycophenolic Acid: A Comprehensive Review of ADME Properties and Their Potential Impact on Mycophenolic Acid Plasma Exposure [0.03%]
与霉酚酸处置相关的生物药剂学因素：霉酚酸吸收、分布、代谢和排泄特性的全面综述及其对霉酚酸血浆暴露的影响
Eric Asare,Ting Du,Huan Xie et al.
Eric Asare et al.
Mycophenolic acid (MPA) is an approved drug widely used as an immunosuppressant agent for the prevention of rejection in organ transplant patients and for managing various autoimmune disorders. Pharma-cological studies have shown that the p...
Poonam Sahu,Trilochan Satapathy
Poonam Sahu
Introduction: This review aims to explore the therapeutic potential and safety of herbal biactive compounds in the treatment of various liver disorders. As the liver plays a critical role in digestion, detoxification, ene...