The Intricacies of Polypharmacy and Drug Interactions in Schizophrenia Treatment [0.03%]
精神分裂症治疗中的多重用药和药物相互作用的复杂性
Jyotsana Dwivedi,Mohd Seemab,Pranay Wal et al.
Jyotsana Dwivedi et al.
Introduction: Polypharmacy is frequently practiced in the management of schizophrenia due to its chronic nature, recurrent relapses, and associated comorbidities. While combining psychotropic medications may benefit patie...
Development of Transdermal Drug Delivery Approaches to Combat Diabetes: An Update [0.03%]
用于对抗糖尿病的经皮药物输送方法的发展：最新研究进展
Priya Singhal,Rupa Mazumder,Anjna Rani et al.
Priya Singhal et al.
Background: Diabetes mellitus, a widespread and chronic metabolic condition, creates signif-icant challenges for healthcare systems due to complications from inadequate glycemic control, patient non-compliance, and the in...
Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review [0.03%]
天然化合物作为胰腺癌潜在治疗药物的叙述性综述
Xing-Da Lin,Tian Li,Rui-Xia Du et al.
Xing-Da Lin et al.
Pancreatic cancer is a highly lethal malignancy with a low 5-year survival rate. This review fo-cuses on natural compounds as potential therapeutics for it. Different types of natural compounds, such as polyphenols, saponins, and alkaloids,...
Amber Rizwan,Husna Shaikh,Humaira Farooqi
Amber Rizwan
Introduction: Cancer poses a tough global health challenge, prompting the exploration of innovative prevention and treatment strategies. Polyphenols, bioactive compounds abundant in various plant-based foods, have gained ...
TOX4 Inhibition in Chronic Hyperglycemia: Effects on Glycation Stress, Hepatic Protection, Epigenetic Mechanisms, Signaling Pathways, and Beta Cell Dynamics [0.03%]
TOX4在慢性高血糖中的抑制作用：对糖基化应激、肝脏保护、表观遗传机制、信号通路和β细胞动态的影响
Bonthu Varunteja,Nayan Gupta,Anjali Kumari et al.
Bonthu Varunteja et al.
TOX high mobility group box family member 4 (TOX4) has emerged as a critical regulator of Hepatic Glucose Production (HGP), particularly under insulin-resistant condi-tions seen in Type 2 Diabetes Mellitus (T2DM). Hyperglycemia-induced form...
Nanocochleates in Clinical Trials: A Review of Current Status, Challenges, and Future Directions [0.03%]
纳米螺旋体在临床试验中的现状、挑战及未来展望综述
Alka Singh,Sushma Verma
Alka Singh
Nanocochleates are novel lipid-based nanoparticles with a distinctive, multilayered, rolled-up structure that resembles the spirals of a cochlea. They form when bivalent cations, such as calcium, interact with negatively charged lipid bilay...
Metabolomics and Network Pharmacology Analyses of Yiqi Huazhuo Decoction in Regulating EGFR Signaling and Metabolic Pathways in Type 2 Diabetes with Insulin Resistance: In Vivo Validation [0.03%]
益气化浊方调节2型糖尿病内皮生长因子受体信号通路及代谢途径的代谢组学与网络药理学分析：体内验证阶段
Sinan Li,Jiaying Liu,Siying Weng
Sinan Li
Introduction: Type 2 diabetes mellitus (T2DM), characterized by insulin resistance (IR) and hepatic ectopic lipid deposition (ELD), poses a complex metabolic challenge. This study aimed to elucidate the mechanisms of Yiqi...
An Explicative Review on Nanotechnology-based Drug Delivery Systems for Alleviating Oxidative Stress-driven Pathologies [0.03%]
基于纳米技术的药物递送系统缓解氧化应激驱动疾病的解释性综述
Dipanjan Karati,Sakuntala Gayen,Swarupananda Mukherjee et al.
Dipanjan Karati et al.
Background: Numerous chronic illnesses, including diabetes, cancer, cardiovascular dis-ease, and neurological disorders, are mostly caused by oxidative stress, which is defined as an imbal-ance between the body's antioxid...
Targeting Metabolic Dysregulation in Alzheimer's Disease: A Potential Therapeutic Strategy [0.03%]
针对阿尔茨海默病代谢紊乱的治疗策略
Nivedita Barnwal,Sonal Dubey,Prashant Tiwari
Nivedita Barnwal
Alzheimer's disease (AD), the most common form of dementia, is characterized by progressive cognitive decline and neuropathological hallmarks, including amyloid-beta plaques and tau tangles. Emerging evidence implicates metabolic dysfunctio...
Transfer of Intravenous Remimazolam into Milk of Lactating Sheep and Uptake by Breast-fed Lambs [0.03%]
瑞美扎隆在泌乳羊奶中的转移和被哺乳小羊的吸收
Wolfgang Schmalix,Maureen Onyuro,Marija Pesic et al.
Wolfgang Schmalix et al.
Introduction: Remimazolam is a short-acting sedative/anesthetic. For safe breastfeeding, infor-mation on the extent and possible risks of remimazolam passing through a mother´s milk to the infant is needed. The objective...