Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia [0.03%]
缺氧条件下表观遗传修饰调控转运体的研究进展
Yilan Zhao,Hongfang Mu,Anpeng Zhao et al.
Yilan Zhao et al.
Epigenetic modification refers to the heritable changes caused by chromosomal changes without changing the DNA sequence. Epigenetics runs through the entire growth and differentiation process of the body, which causes varied diseases. Hypox...
Application of Nucleic Acid Nanomaterials in the Treatment of Endocrine and Metabolic Diseases [0.03%]
核酸纳米材料在内分泌和代谢性疾病治疗中的应用研究进展
Qiang Zhu,Yuping Xie,Ting Fu et al.
Qiang Zhu et al.
Endocrine and metabolic diseases are the most prevalent chronic diseases globally, posing the greatest hazard to human health. Although various medications are applied in treating endocrine and metabolic illnesses, numerous obstacles exist ...
Hao-Jian Zhang,Yan Wang,Jian-Dong Jiang
Hao-Jian Zhang
Atherosclerosis (AS) is one of the major risk factors for cardiovascular disease pathogenesis, and current studies have found that the development of atherosclerosis is closely related to the intestinal microbiome. This review describes the...
Meropenem for the Pharmacological Treatment of Severe Infections in Critically Ill Pediatric Patients: Breakthrough Standard Treatment Strategies Based on PK/PD [0.03%]
儿科重症感染患者美罗培南的药理治疗：基于PK/PD的突破性标准治疗策略
Xin He,Xiaoyan Liu,Xiaodan Gong et al.
Xin He et al.
Meropenem, as a carbapenem antibiotic, is commonly used in critically ill pediatric patients with severe infection because of its broad antimicrobial spectrum, high penetration into tissues, and favorable safety profile. Due to pathophysiol...
The Effect of Retroconversion Metabolism of N-oxide Metabolites by Intestinal Microflora on Piperaquine Elimination in Mice, as well as in Humans Predicted Using a PBPK Model [0.03%]
基于PBPK模型预测的小鼠及人体肠道菌群NO至PQ的逆转化代谢对帕奎林消除的影响
Hongchang Zhou,Liyuan Zhang,Jianbo Ji et al.
Hongchang Zhou et al.
Background: Piperaquine (PQ) and its pharmacologically active metabolite PQ N-oxide (PM1) can be metabolically interconverted via hepatic cytochrome P450 and FMO enzymes. ...
New Psychoactive Substances, New Behaviours, New Drug-drug Interactions: Pharmacology of a Slam Session [0.03%]
新型精神活性物质的新行为和新药-药相互作用：萨满音乐会上的精神药物学
Benoit Schreck,Marion Istvan,Marylène Guerlais et al.
Benoit Schreck et al.
Background: Slamming has been increasing internationally for ten years, mostly among men who have sex with men. Slamming consists of injecting psychostimulants (including new psychoactive substances-NPS) intravenously to ...
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview [0.03%]
含烟草的都卜尔嚼块与药物代谢途径相互作用的概述
Jasmine Canlas,Alan L Myers
Jasmine Canlas
Global estimates indicate that over 600 million individuals worldwide consume the areca (betel) nut in some form. Nonetheless, its consumption is associated with a myriad of oral and systemic ailments, such as precancerous oral lesions, oro...
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O- β-D-glucoside, the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects [0.03%]
何首乌标志性活性成分茋-2-O-β-D-葡萄糖苷的肝效应研究进展与展望
Cheng-Yu Wang,Ying-Huan Hu,Zhen-Xiao Sun
Cheng-Yu Wang
Traditional Chinese medicine Heshouwu, named Polygoni Multiflori Radix in Pharmacopoeia of the People's Republic of China (PPRC, 2020), is derived from the root tuber of Polygonum multiflorum Thunb., Heshouwu or processed Heshouwu is well k...
Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 In vitro [0.03%]
体内狼毒素双咖啡酰スピルミジン派生物作为人细胞色素P450 46A1的高效和选择性抑制剂的表征
Jie Du,Jing Liu,Shujuan Wang et al.
Jie Du et al.
Background: Cytochrome P450 (CYP) 46A1 enzyme is a neuro-specific metabolic enzyme that converts cholesterol to 24-hydroxycholesterol. Inhibition of CYP46A1 activity is of great significance to improve neurodegenerative d...
Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients [0.03%]
SLCO1B1多态性对肾移植受者的霉酚酸药代动力学的影响
Jiawen Liu,Yongqian Zhu,Jiexiu Zhang et al.
Jiawen Liu et al.
Objective: This study was designed to analyze the correlation between single nucleotide polymorphisms (SNP) related to drug metabolism and pharmacokinetics of mycophenolic acid (MPA) during long-term follow-up. ...