Global Xenobiotic Profiling of Rat Plasma Using Untargeted Metabolomics and Background Subtraction-Based Approaches: Method Evaluation and Comparison [0.03%]
基于非目标代谢组学和背景消除法的全球异生物血浆分析方法评估及比较研究
Xiaojuan Jiang,Simian Chen,Mingshe Zhu et al.
Xiaojuan Jiang et al.
Background: Global xenobiotic profiling (GXP) is to detect and structurally characterize all xenobiotics in biological samples using mainly liquid chromatography-high resolution mass spectrometry (LC-HRMS) based methods. ...
The Metabolic Pathways and Products of Ten Aconitum Alkaloids in Sanwujiao Pills from Eight Organs of Mice by UHPLC-Q-TOF-MS/MS [0.03%]
基于UHPLC-Q-TOF-MS/MS的八种小鼠脏器中十种乌头碱类生物代谢路径及代谢产物研究：以三物白散为例
Wen-Han Pei,Yu-Feng Huang,Ying Xie et al.
Wen-Han Pei et al.
Background: Sanwujiao pill (SWJP) is a Chinese herbal preparation widely used in China. It is an essential medicine for treating rheumatism and blood stasis. However, its safety in clinical use has always been the focus o...
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines [0.03%]
基于LC-Q-TOF/MS的九种苯二氮卓药物的裂解行为研究及体外代谢产物鉴定
Shuhan Zhou,Xiaoting Song,Pengkai Fang et al.
Shuhan Zhou et al.
Background: Benzodiazepines (BZDs) are compounds that contain one diazepine ring and two benzene rings, and are widely used to treat central nervous system diseases. However, drug abuse and BZDs' illegal addition may affe...
Folate Targeting Peptide Conjugates for Inflammatory Response Suppression [0.03%]
叶酸靶向肽结合物在炎症反应抑制中的应用
Elizabeth Ruff,Scott Poh
Elizabeth Ruff
Background and objective: Protein kinases known as mitogen-activated protein kinases (MAPKs) are responsible for regulating a wide variety of physiological cell responses by generating and release of inflammatory mediator...
Pharmacokinetic Drug-Drug Interactions Involving Antiretroviral Agents: An Update [0.03%]
涉及抗逆转录病毒药物的药代动力学生物药物相互作用的新进展
Xin Yu,Lifeng Zhao,Zheng Yuan et al.
Xin Yu et al.
Antiretroviral therapy is the recognized treatment for human immunodeficiency virus (HIV) infection involving several antiviral agents. Even though highly active antiretroviral therapy has been proven to be very effective in suppressing HIV...
Factors Influencing ADME Properties of Therapeutic Antisense Oligonucleotides: Physicochemical Characteristics and Beyond [0.03%]
影响治疗性反义寡核苷酸ADME属性的因素：物理化学性质及其他因素
Rongrong Jiang,Shirin Hooshfar,Marsha Rebecca Eno et al.
Rongrong Jiang et al.
Therapeutic antisense oligonucleotides (ASOs) represent a diverse array of chemically modified singlestranded deoxyribonucleotides that work complementarily to affect their mRNA targets. They vastly differ from conventional small molecules....
Mengchen Liu,Jiaqiang Xu,Qianna Jin et al.
Mengchen Liu et al.
Introduction: It is well known that the response to and metabolism of the drugs entering the human body varies widely across individuals. One of the reasons is that such interpersonal differences may be related to gut mic...
Hongxiao Huang,Shaojingya Gao,Xiaoxiao Cai
Hongxiao Huang
Background: Nucleic acid is a genetic material that shows great potential in a variety of biological applications. With the help of nanotechnology, the fabrication of DNA-based nanomaterials has emerged. From genetic DNA ...
Evaluation of Intracellular Metabolism of Methotrexate in Hepatocytes and Embryonic Kidney Cells based on Folylpolyglutamate Synthetase and Gamma-Glutamyl Hydrolase Expression [0.03%]
基于叶酸多聚谷氨酸合成酶和γ-谷氨酰水解酶表达的肝细胞和胚胎肾细胞亚细胞代谢评价研究
Hanbing Jiang,Jie Yang,Yucui Hou et al.
Hanbing Jiang et al.
Background: Methotrexate (MTX) is a common folic acid antagonist in clinical medicine, easily inducing a common adverse side effect of liver and kidney injury. It has been found that the expression of Folylpolyglutamate S...
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats [0.03%]
基于集成16SrRNA测序和非靶向代谢组学分析的 Siberian 山参多糖干预2型糖尿病模型大鼠保护机制研究
Hui Zhang,Hanzhou Li,Baochao Pan et al.
Hui Zhang et al.
Background: Polygonatum sibiricum polysaccharide (PSP) can improve insulin resistance and inhibit oxidative stress. However, the detailed anti-diabetic mechanism of PSP is still poorly defined. ...