Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin [0.03%]
基于计算的结构变异型CYP2C9验证及评估机器学习算法预测华法林治疗结果的能力
Kannan Sridharan,Thirumal Kumar D,Suchetha Manikandan et al.
Kannan Sridharan et al.
Aim: The study aimed to identify the key pharmacogenetic variable influencing the therapeutic outcomes of warfarin using machine learning algorithms and bioinformatics tools. ...
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction [0.03%]
核酸纳米材料在治疗线粒体功能障碍中的应用
Lan Yao,Qing Hai,Tao Zhang
Lan Yao
Mitochondrial dysfunction is considered highly related to the development and progression of diseases, including cancer, metabolism disturbance, and neurodegeneration. Traditional pharmacological approach for mitochondrial dysfunction treat...
Structure of the Blood Brain Barrier and its Role in the Transporters for the Movement of Substrates across the Barriers [0.03%]
血脑屏障的结构及其在底物转运中的作用
S Ankul Singh,Chitra Vellapandian
S Ankul Singh
For the brain to operate normally and to develop with structural integrity in addition to neuronal function, blood-brain barrier present in brain capillaries serves as a vital barrier mechanism. In addition to the transport barrier created ...
Metabolism Pathways of Major Therapeutics for Treating Monkeypox Mono- and Co-infection with Human Immunodeficient Virus or SARS-CoV-2 [0.03%]
猴痘单发和人免疫缺陷病毒或新型冠状病毒合并感染的主要治疗药物代谢途径
Daisy Yan,Bingfang Yan
Daisy Yan
Monkeypox is a zoonotic viral disease and remains endemic in tropical regions of Central and West Africa. Since May of 2022, cases of monkeypox have soared and spread worldwide. Confirmed cases have shown no travel history to the endemic re...
Xueping Xie,Wenjuan Ma,Yuxi Zhan et al.
Xueping Xie et al.
Nucleic acid strands can be synthesized into various nucleic acid-based nanomaterials (NANs) through strict base pairing. The self-assembled NANs are programmable, intelligent, biocompatible, non-immunogenic, and non-cytotoxic. With the rap...
State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research [0.03%]
人工智能在 transporter 中心式功能和药理研究中的最新应用进展
Jiayi Yin,Nanxin You,Fengcheng Li et al.
Jiayi Yin et al.
Protein transporters not only have essential functions in regulating the transport of endogenous substrates and remote communication between organs and organisms, but they also play a vital role in drug absorption, distribution, and excreti...
Factors Influencing ADME Properties of Drugs: Advances and Applications (Part I) [0.03%]
影响药物ADME性质的因素：进展与应用（一）
Shuang-Qing Zhang,Feng Chen
Shuang-Qing Zhang
Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition [0.03%]
药物代谢与处置领域中研究转录后基因调控的新型重组RNA的最新进展
Mei-Juan Tu,Ai-Ming Yu
Mei-Juan Tu
Drug-metabolizing enzymes and transporters are major determinants of the absorption, disposition, metabolism, and excretion (ADME) of drugs, and changes in ADME gene expression or function may alter the pharmacokinetics/ pharmacodynamics (P...
Comparative Pharmacokinetics of Scoparone and its Metabolite Scopoletin in Normal and ANIT-induced Intrahepatic Cholestatic Rats [0.03%]
穿心莲内酯衍生物及其代谢物在正常大鼠和ANIT致肝胆汁淤积大鼠体内的药动学比较研究
Qiru Tian,Huan Jin,Xiaokui Huo et al.
Qiru Tian et al.
Background: Scoparone, the principal natural active ingredient of Artemisia capillaries (Yin Chen), can effectively treat cholestatic diseases, but the pharmacokinetic properties of scoparone are rarely studied in intrahe...
Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in Geriatric Drug Research [0.03%]
基于生理的药代动力学模型在老年药物研究中的应用及展望
Xinyi Wu,Jie En Valerie Sia,Min Hai et al.
Xinyi Wu et al.
Drug-related adverse events are higher in older patients than in non-older patients, increasing the risk of medication and reducing compliance. Aging is accompanied by a decline in physiological functions and metabolic weakening. Most tissu...