Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease [0.03%]
CHEBULIN酸的药代动力学及代谢疾病治疗作用研究
Arpon Biswas,Sarvesh Kumar Verma,Shiv Kumar et al.
Arpon Biswas et al.
Background: Chebulinic acid (CA) is an active constituent of Terminalia chebula fruits with therapeutic potential against multiple metabolic diseases, including dementia, benign prostate hyperplasia, and osteoporosis. ...
Herbal Medicines as Adjuvants for the Treatment of Chemotherapy-Induced Diarrhea [0.03%]
草药作为辅助治疗化疗引起的腹泻药物
Zicong Zheng,Songpol Srinual,Jie Chen et al.
Zicong Zheng et al.
Background: Chemotherapeutic drugs used in cancer treatment often result in gastrointestinal toxicity, notably diarrhea, impacting patients' quality of life. Complementary and Alternative Medicine (CAM) has garnered incre...
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites [0.03%]
硝呋替莫的体内代谢及其药物相互作用潜能（包括主要代谢产物）
Simone I Schulz,Dieter Lang,Gabriele Schmuck et al.
Simone I Schulz et al.
Background: Nifurtimox is an effective treatment for patients with Chagas disease, but knowledge of its biotransformation and excretion is limited. Object...
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib [0.03%]
质子泵抑制剂对Palbociclib和Ribociclib-P-糖蛋白介导的药物转运调控作用机制的分子见解
Mrunal Pradeep Desai,Prajakta Harish Patil,Sai Krishna Anand Vullendula et al.
Mrunal Pradeep Desai et al.
Background: Palbociclib and ribociclib are substrates of efflux transporter P-glycoprotein which plays a key role in absorption and transport of these drugs. Proton pump inhibitors, when co-administered with them are know...
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by UHPLC-MS [0.03%]
基于UHPLC-MS的大鼠体内乳香和没药配伍前后3个主要倍半萜类化合物的药代动力学及代谢物比较研究
Ruo-Ying Fan,Ru-Meng Gao,Jia-Shang Li et al.
Ruo-Ying Fan et al.
Background: 3-acetyl-11-keto-beta-boswellic acid (AKBA) and 11-keto-boswellic acid (KBA) are the main active components of frankincense as pentacyclic triterpenoids, which are designated by the European Pharmacopoeia 8.0 ...
A Mini-review on Recent Strategies and Applications of Nanomedicines to Combat Antimicrobial Resistance [0.03%]
纳米药物抗微生物耐药性策略和应用的 mini 综述
Kanak Chahar,Yash Sharma,Preeti Patel et al.
Kanak Chahar et al.
One of the key factors contributing to mortality and morbidity globally is infectious ailments. According to recent statistics from WHO, amplified antimicrobial resistance occurrence among bacteria signifies the utmost threat to global publ...
Covalent Modification of Proteins by Osthole Reactive Metabolites using Proteomic Approaches [0.03%]
采用蛋白质组学方法研究欧前胡素反应代谢物对蛋白质的共价修饰作用
Yue Zhuo,Huiling Chen,Chenchen Liu et al.
Yue Zhuo et al.
Background: Osthole (OST) is a bioactive natural coumarin derived from the plant Cnidium monnieri (L.) Cusson fruit (She Chuang Zi), which has various pharmacological and biological activities. OST contains an α,β- unsa...
Beatriz Dias Januário,Natália Silva Mafra,Humberto de Souza Silva et al.
Beatriz Dias Januário et al.
Introduction: The present study has compiled the prevalence of polypharmacy worldwide and assessed the prevalence of polypharmacy in different populations, including community-dwelling individuals, hospitalized patients, ...
Qi Zhang,Shiyu Lin,Junyu Shi
Qi Zhang
Deoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the sy...
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke [0.03%]
地高辛[3H]芍药苷在大鼠体内的药动学、体内平衡、组织分布和代谢：地高辛为玄参属生地黄的主要活性成分，用于治疗缺血性卒中
Xinyu Ge,Yuandong Zheng,Yifei He et al.
Xinyu Ge et al.
Background: Catalpol, one of the main bioactive components isolated from Rehmannia glutinosa, was developed by Suzhou Youseen for the treatment of ischemic stroke; however, preclinical information about its absorption, di...