Prachi Varshney,Vishal Sharma,Devdhar Yadav et al.
Prachi Varshney et al.
Background: Cancer drug resistance remains a difficult barrier to effective treatment, necessitating a thorough understanding of its multi-layered mechanism. ...
Comparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep [0.03%]
静脉注射恩诺沙星在1月龄、6月龄和12月龄绵羊中的比较药代动力学研究
Devran Coskun,Orhan Corum,Duygu Durna Corum et al.
Devran Coskun et al.
Background: Enrofloxacin (ENR) is a fluoroquinolone antibiotic approved for use in sheep of all ages. The body composition and metabolic capability change with age. These changes may alter the pharmacokinetics of drugs an...
Handan Tanyildizi-Kökkülünk,Ahmet Murat Şenişik,Mahmut Yüksel
Handan Tanyildizi-Kökkülünk
Aim: This study was aimed to re-determine the radiation dose rate emitted from the patients who underwent bone scintigraphy. Material and methods: ...
Mohammad Hossein Asgarshamsi,Mehrdad Mohammadpour Dehkordi,Seyed Mohamad Reza Nazifi et al.
Mohammad Hossein Asgarshamsi et al.
Background: Decarboxymethyl ligstroside aglycone (Oleocanthal) is an essential component of olive oil. It is therefore interesting to study its metabolism in the human body. In order to find the best possible starting poi...
Pharmacokinetics, Mass Balance, Tissue Distribution and Metabolism of [14C]101BHG-D01, a Novel Muscarinic Receptor Antagonist, in Rats [0.03%]
101BHG-D01的药动学、体内动态平衡、组织分布和代谢研究
Huaye Gao,Cheng Yang,Wenhui Hu et al.
Huaye Gao et al.
Background: 101BHG-D01, a novel long-acting and selective muscarinic receptor antagonist for the treatment of chronic obstructive pulmonary disease (COPD), is undergoing Phase Ib clinical trial in patients and has shown i...
In Silico Tools to Thaw the Complexity of the Data: Revolutionizing Drug Research in Drug Metabolism, Pharmacokinetics and Toxicity Prediction [0.03%]
解冻数据复杂性的计算机工具：药物代谢、药代动力学和毒性预测领域的药物研究革新
Hema Sree Kommalapati,Pushpa Pilli,Vijaya Madhyanapu Golla et al.
Hema Sree Kommalapati et al.
In silico tool is the flourishing pathway for Researchers and budding chemists to strain the analytical data in a snapshot. Traditionally, drug research has heavily relied on labor-intensive experiments, often limited by time, cost, and eth...
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population [0.03%]
特定药理基因差异对非洲黑人抗逆转录病毒药物代谢影响的研究
Riaan Reay,Michelle Viljoen,Malie Rheeders
Riaan Reay
Background: Genetic polymorphism of drug-metabolising enzymes and transporters may influence the effect and toxicity of antiretroviral drugs. Objectives: ...
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice [0.03%]
クロシンはメタボリズム、CYP4A11/PPARγおよびTGF-β/Smad経路を介して糖尿病腎症の改善に寄与する：マウスモデルを用いた研究
Wei Chen,Jinhao Su,Yubin Liu et al.
Wei Chen et al.
Introduction: Crocin is one of the main components of Crocus sativus L. and can alleviate oxidative stress and inflammation in diabetic nephropathy (DN). However, the specific mechanism by which crocin treats DN still nee...
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol [0.03%]
监督机器学习算法评估和对乙酰氨基酚急性肝损伤相关单核苷酸多态性的计算结构验证
Kannan Sridharan,Ambritha Balasundaram,D Thirumal Kumar et al.
Kannan Sridharan et al.
Aims: To identify single nucleotide polymorphisms (SNPs) of paracetamol-metabolizing enzymes that can predict acute liver injury. Background: ...
Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice [0.03%]
阿托伐他汀对小鼠拉科酰胺和左乙拉西胺抗惊厥药代动力学及相互作用的影响
Jayaraman Rajangam,Arun Prasath Lakshmanan,Narahari N Palei et al.
Jayaraman Rajangam et al.
Background: The beneficial effects of statins, other than their hypocholesterolemia role, have been well documented, however, their use as an adjuvant drug with other antiseizure drugs, in the treatment of epilepsy is poo...