Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes [0.03%]
金丝桃素体内外代谢研究及其种属差异性评估
Yi-Rong Wang,Meng-Ting Zuo,Wen-Bo Xu et al.
Yi-Rong Wang et al.
Aim: The aim of this study was to investigate the metabolism of Gelsemium elegans in human, pig, goat and rat liver microsomes and to elucidate the metabolic pathways and cleavage patterns of the Gelsemium alkaloids among...
Yogita Shinde,Gitanjali Deokar
Yogita Shinde
Preserving host health and homeostasis is largely dependent on the human gut microbiome, a varied and ever-changing population of bacteria living in the gastrointestinal tract. This article aims to explore the multifaceted functions of the ...
Wolfgang Schmalix,Karl-Uwe Petersen,Marija Pesic et al.
Wolfgang Schmalix et al.
Background: Remimazolam (RMZ) is a novel ultrashort-acting benzodiazepine used for sedation by intravenous administration. The pharmacophore of RMZ includes a carboxyl ester group sensitive to esterase- mediated hydrolysi...
Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems [0.03%]
克拉霉素和酮康唑在不同CYP3A4基因型重组代谢酶系统中对FK506代谢的影响
Jinhua Wen,Yuwei Xiao,Menghua Zhao et al.
Jinhua Wen et al.
Objective: This study aimed to investigate the effects of clarithromycin and ketoconazole on the pharmacokinetic properties of tacrolimus in different CYP3A4 genotype recombinant metabolic enzyme systems, so as to underst...
Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study [0.03%]
COMT基因多态性在多巴胺介导的血管加压效应中的作用机制：横断面观察研究
Kannan Sridharan,Anfal Jassim,Ali Mohammed Qader et al.
Kannan Sridharan et al.
Aims: To evaluate the association between rs4680 polymorphism in the COMT gene and the vasoconstrictive effects of commonly used vasopressors. Background:...
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients [0.03%]
UGT1A基因多态性与肾移植受者的BKV感染的相关性研究
Jingwen Yuan,Shuang Fei,Zeping Gui et al.
Jingwen Yuan et al.
BK virus (BKV) infection is an opportunistic infectious complication and constitutes a risk factor for premature graft failure in kidney transplantation. Our research aimed to identify associations and assess the impact of single-nucleotide...
Vangelis G Manolopoulos,Georgia Ragia
Vangelis G Manolopoulos
Background: Fluoropyrimidine-induced toxicity is a main limitation of therapy. Currently, polymorphisms in the DPYD gene, which encodes the 5-FU activation enzyme dihydropyrimidine dehydrogenase (DPD), are used to adjust ...
Safety Aspects of Herb Interactions: Current Understanding and Future Prospects [0.03%]
草药相互作用的安全性方面：当前的理解和未来展望
Subhajit Hazra,Preet Amol Singh
Subhajit Hazra
Background: The use of herbal medicines is on the rise throughout the world due to their perceived safety profile. However, incidences of herb-drug, herb-herb and herb-food interactions considering safety aspects have ope...
Lijun Li,Xuejun Wang,Sheng Wang et al.
Lijun Li et al.
Background: Propofol is an intravenous agent for clinical anesthesia. As the influence of the hypobaric- hypoxic environment (Qinghai-Tibetan region, altitude: 2800-4300 m, PaO2: 15.1-12.4 kPa) on the metabolism of Propof...
Subhajit Hazra,Preet Amol Singh,Neha Bajwa
Subhajit Hazra
Warfarin is a popular anticoagulant with high global demand. However, studies have underlined serious safety issues when warfarin is consumed concomitantly with herbs or its formulations. This review aimed to highlight the mechanisms behind...