Reema Savaliya,Darshini Shah,Ragini Singh et al.
Reema Savaliya et al.
Currently the major research highlights of bioengineering and medical technology are directed towards development of improved diagnostic techniques to screen complex diseases. Screening requirements are for the identification of the cause o...
Novel Atypical Antipsychotics: Metabolism and Therapeutic Drug Monitoring (TDM) [0.03%]
新型非典型抗精神病药：代谢与治疗药物监测(TDM)
Roberto Mandrioli,Michele Protti,Laura Mercolini
Roberto Mandrioli
Medicinal chemistry is continually developing and testing new drugs and drug candidates to satisfactorily address the needs of patients suffering from schizophrenia. In the last few years, some significant additions have been made to the li...
Nucleic Acids Delivery Systems: A Challenge for Pharmaceutical Technologists [0.03%]
核酸递送系统：医药技术领域的挑战
Ana C Silva,Carla M Lopes,Jose M Sousa Lobo et al.
Ana C Silva et al.
Nucleic acids (NA) therapies, including therapy with genes, aptamers or antisense oligonucleotides, have been showing promising results, especially in the treatment of severe diseases (e.g. cancer and AIDS). Nevertheless, the full success o...
Recent Advances in the Methodology and Application for the Metabolism of Phytochemical Compounds-An Update Covering the Period of 2009-2014 [0.03%]
植物化学成分代谢研究的新进展(2009-2014年)
Wan Cao,Ling Yi,Jun Cao et al.
Wan Cao et al.
The research of drug metabolism is essential for successful drug discovery. Phytochemicals, particularly those from herbal medicines, have the potential to affect diseases such as cancer, heart disease, diabetes, and high blood pressure, et...
PepT1, ASBT-Linked Prodrug Strategy to Improve Oral Bioavailability and Tissue Targeting Distribution [0.03%]
基于PepT1、ASBT的前药策略改善口服生物利用度和组织靶向分布研究
Xiaopeng Han,Jin Sun,Yongjun Wang et al.
Xiaopeng Han et al.
With the rapid development of molecular biology, various of drug transporters have been discovered in several important organs of the body, which determine intracellular exposure and pharmacokinetic performances of drugs by modulating cellu...
Interplay of Drug-Metabolizing Enzymes and Transporters in Drug Absorption and Disposition [0.03%]
药物代谢酶和转运蛋白在药物吸收和处置中的相互作用
Shaojun Shi,Yunqiao Li
Shaojun Shi
In recent years, the functional interplay between drug-metabolizing enzymes (DMEs) and drug transporters (DTs) in drug absorption and disposition, as well as the complex drug interactions (DIs), has become an intriguing contention, which ha...
Quantitative evaluation of drug-drug interaction potentials by in vivo information- guided prediction approach [0.03%]
基于体内信息的药物相互作用潜在毒性定量评价模型构建及应用研究
Feng Chen,Zhe-Yi Hu,Wei-Wei Jia et al.
Feng Chen et al.
Drug-drug interaction (DDI) is one important topic in drug discovery, drug development and clinical practice. Recently, a novel approach, in vivo information-guided prediction (IVIP), was introduced for predicting the magnitude of pharmacok...
Are circulating metabolites important in pharmacokinetic drug-drug interactions? A retroanalysis of clinical data [0.03%]
临床数据的回溯分析：循环代谢物在药动学药物相互作用中重要吗？
Yuan-Sheng Zhao,Feng Chen,Li Li
Yuan-Sheng Zhao
Pharmacokinetic (PK) drug-drug interactions (DDIs) give rise to adverse events and/or reduced efficacy. Comprehensive, systematic and mechanistic approaches have been applied in the evaluation, propagation and management of the interaction ...
Pharmacokinetic interactions between herbal medicines and prescribed drugs: focus on drug metabolic enzymes and transporters [0.03%]
中药与处方药之间的药物动力学相互作用：重点在于药物代谢酶和转运蛋白
Qiang Meng,Kexin Liu
Qiang Meng
Herbal medicines have been widely used for thousands of years, and now are gaining continued popularity worldwide as a complementary or alternative treatment for a variety of diseases, rehabilitation and health care. Since herbal medicines ...