Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice [0.03%]
苓桂术甘汤通过调节小鼠肠道菌群及其代谢物改善肥胖症状
Meiling Wang,Hairong Li,Chunmei Liu et al.
Meiling Wang et al.
Background: The global obese population is rapidly increasing, urgently requiring the development of effective and safe weight-loss medications. The classic Chinese medicine formulation Lingguizhugan De-coction has exerte...
Emerging Trends in Hybrid Nanoparticles: Revolutionary Advances and Promising Biomedical Applications [0.03%]
混合纳米颗粒新兴趋势：革命性进展及 promising 生物医学应用
Harish Bhardwaj,Sulekha Khute,Ram Kumar Sahu et al.
Harish Bhardwaj et al.
Modern nanostructures must fulfill a wide range of functions to be valuable, leading to the combination of various nano-objects into hierarchical assemblies. Hybrid Nanoparticles (HNPs), comprised of multiple types of nanoparticles, are eme...
Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies [0.03%]
胡椒碱的药动学药物相互作用：综述前临床和临床研究结果
Imtiyaz Ahmed Najar,Sagar Pamu,Anushka Paul et al.
Imtiyaz Ahmed Najar et al.
Piperine (amide alkaloid) derived from pepper is globally utilized in diverse conventional and traditional systems of medicine. The co-administration of piperine has been observed to induce subtle modifications in the absorption, membrane t...
Drug-Drug Interaction Potential of Remimazolam Mediated by CYP 450, Transporters, and Protein Binding [0.03%]
雷米唑胺的药物相互作用潜力由CYP 450、转运体和蛋白结合介导
Karl-Uwe Petersen,Wolfgang Schmalix,Marija Pesic et al.
Karl-Uwe Petersen et al.
Background: The ultra-short-acting benzodiazepine, remimazolam, is a new treatment modality for procedural sedation and general anesthesia. Its activity is terminated by carboxylesterase 1 (CES1). ...
Avapritinib Carries the Risk of Drug Interaction via Inhibition of UDP-Glucuronosyltransferase (UGT) 1A1 [0.03%]
阿伐普利尼通过抑制尿苷二磷酸葡萄糖醛酸转移酶(UGT)1A1导致药物相互作用的风险
Xin Lv,Zhen Wang,Zhe Wang et al.
Xin Lv et al.
Background: Avapritinib is the only drug for adult patients with PDGFRA exon 18 mutated unresectable or metastatic gastrointestinal stromal tumor (GIST). Although avapritinib has been approved by the FDA for four years, l...
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases [0.03%]
甘草多糖体外和体内对人细胞色素P450 46A1的抑制作用及其在治疗神经性疾病中的应用前景
Jie Du,Zujia Chen,Xiaodong Chen et al.
Jie Du et al.
Background: Cytochrome P450 (CYP) 46A1, also known as cholesterol 24S-hydroxylase, is essential for maintaining the homeostasis of cholesterol in the brain and serves as a therapeutic target of neurodegenerative disorders...
Comprehensive Analysis of Chemical Ingredients of Waiganfengsha Granule and Absorbed Components in Rat Plasma Based on UHPLC-Q-TOF-MS [0.03%]
基于UHPLC-Q-TOF-MS的外感风痧颗粒化学成分及其大鼠血浆中吸收成分的整体调控作用分析
Wei Wei,Liyuan Huang,Jun Huang et al.
Wei Wei et al.
Objective: Waiganfengsha Granule, an over-the-counter drug, is commonly used for treating windheat cold and sore throat in clinical settings. However, its material basis of medicinal efficacy is still unclear. In this stu...
Curcumin Nanogel Preparations: A Promising Alternative for Psoriasis Treatment [0.03%]
纳米姜黄素胶束治疗银屑病的前景展望
Asad Ahmad,Juber Akhtar,Mohammad Ahmad et al.
Asad Ahmad et al.
Curcumin is a naturally occurring polyphenolic compound extracted from the rhizomes of Curcuma longa, commonly known as turmeric. It has been used for centuries in traditional medicine and is gaining increasing attention in modern medicine ...
Disposition Kinetics of Cathinone and its Metabolites after Oral Administration in Rats [0.03%]
口服卡西酮及代谢产物在大鼠体内的动态变化
Fahad Y Sabei,Ibrahim Khardali,Mohamed A Al-Kasim et al.
Fahad Y Sabei et al.
Background: Cathinone is a natural stimulant found in the Catha edulis plant. Its derivatives make up the largest group of new psychoactive substances. In order to better understand its effects, it is imperative to invest...