In silico Exploration of Aegle Marmelos-Derived Compounds as Potential Inhibitors of NS5 RdRp in Japanese Encephalitis Virus [0.03%]
印度洋参衍生物抑制日本脑炎病毒NS5 RdRp的虚拟筛选及对接研究
Pardeep Yadav,Rani Astya,Siva Prasad Panda et al.
Pardeep Yadav et al.
Introduction: Japanese encephalitis virus (JEV) hijacks the host cell's endoplasmic reticulum (ER) to form assembly and replication complexes during replication, leading to the production of multiple copies of JEV negativ...
Efficacy of Anti-Histaminic Agents in Asthma Management: A Critical Scientific Analysis [0.03%]
抗组胺药物在哮喘管理中的疗效：一种批判性科学分析
Ekta Verma,Shweta Mishra,Jeetendra Kumar Gupta et al.
Ekta Verma et al.
Introduction: Allergic asthma is triggered by allergens and is commonly associated with elevated IgE levels. Histamine plays a pivotal role in its pathogenesis; however, the therapeutic role of antihistamines remains cont...
Network Pharmacology and Molecular Docking Analyses of Jiao-Tai-Wan Indicate that Adenosine and its Receptors are Potential Targets for Treating Insomnia [0.03%]
网络药理学和分子对接技术分析交泰丸治疗失眠的作用机制及腺苷受体为潜在靶点的研究
Sisi Lin,Zhuocheng Shan,Ze Lin et al.
Sisi Lin et al.
Introduction: This study aimed to explore the underlying pharmacological mechanisms of Jiao-Tai-Wan (JTW) in insomnia. Methods: Network...
Wuhu Decoction Alleviates Airway Inflammation via Regulating miRNA-155 and T-bet/GATA3 in Asthmatic Rats [0.03%]
芜花汤通过调节哮喘大鼠miRNA-155及T-bet/GATA3来缓解气道炎症作用机制研究
Yi Ding,Jing Luo,Yi-Jue Deng et al.
Yi Ding et al.
Introduction: Asthma is characterized by chronic airway inflammation and Th1/Th2 immune imbalance. Wuhu decoction (WHD), a classic formulation in Traditional Chinese Medicine, has demonstrated significant clinical efficacy in managing asthm...
An Optimization Scheme Based on the Simulated Annealing Algorithm for In situ DNA Microarray Synthesis [0.03%]
基于模拟退火算法的原位DNA微阵列合成优化方案研究
Qizhen Zhu,Hengyu Li,Kun Bi et al.
Qizhen Zhu et al.
Introduction: DNA microarray synthesis enables the large-scale and precise generation of DNA sequences for genomic research, data storage, and synthetic biology. However, the order of nucleotide addition significantly aff...
Network Pharmacology and Multi-omics Investigation of Yiqi Huoxue Formula's Molecular Mechanisms in Treating Endometriosis [0.03%]
益气活血方治疗子宫内膜异位症的网络药理学及多组学研究
Dongyi Shen,Panwei Hu,Jianting Lao et al.
Dongyi Shen et al.
Introduction: Endometriosis (EMs), a prevalent disorder characterized by pelvic pain and infertility, affects numerous bodily systems and markedly diminishes life quality. Yiqi Huoxue formula (YQHXF) has demonstrated prom...
The Potential Mechanisms of Total Flavonoids of Drynaria roosii Nakaike in the Treatment of Ovariectomized Osteoporotic Rats through the SDF-1/CXCR4 Axis and BMSCs [0.03%]
干燥卷柏总黄酮通过SDF-1/CXCR4轴及BMSCs改善卵巢切除绝经后骨质疏松症大鼠的机制研究
Chang Tan,Shibo Cong,Jiajia Zhang et al.
Chang Tan et al.
Introduction: The aim of this study was to investigate the potential mechanisms and therapeutic effects of Total Flavonoids of Drynaria roosii Nakaike (TFRD) on osteoporotic rats following ovariectomy, through modulation ...
CDK1 Signaling in Cancer Treatment: Advances in AI-based Strategies and Tools for New Cancer Drug Discovery [0.03%]
CDK1信号通路在癌症治疗中的作用：基于人工智能的新抗癌药物发现策略及工具研究进展
Rajesh Basnet,Yujian Wu,Zhaoming Liu et al.
Rajesh Basnet et al.
Cyclin-Dependent Kinases (CDKs) are proteins that help control the cell cycle. They are considered potential targets for cancer treatment because they are often found at higher levels in cancer tissues than in normal tissues, and their pres...
Network Pharmacology Analysis of Chinese Patent Medicine Zishen Yutai Pills Treating Recurrent Spontaneous Abortion and In Vitro Validation [0.03%]
滋肾育胎丸治疗复发性自然流产的网络药理学分析及体外验证
Jiewen Zhou,Tingting Chen,Xiufei Pang et al.
Jiewen Zhou et al.
Introduction: This study aims to assess the therapeutic mechanisms of Zishen Yutai Pills (ZYP) in treating recurrent spontaneous abortion (RSA) using network pharmacology analysis and in vitro validation of the molecular ...
Exploring the Anti-Rheumatoid Arthritis Inflammatory Mechanism of Shikonin Based on Network Pharmacology and Experimental Validation [0.03%]
基于网络药理学和实验验证探究北豆根抗类风湿关节炎的炎症机制
Yong-Gang Wu,Jing Jiang,Meng-Ying Jiang et al.
Yong-Gang Wu et al.
Introduction: Shikonin (SKN) is known for its anti-inflammatory effects; however, the molecular mechanisms underlying its therapeutic action in rheumatoid arthritis (RA) remain unclear. This study aimed to investigate the...