An Optimization Scheme Based on the Simulated Annealing Algorithm for In situ DNA Microarray Synthesis [0.03%]
基于模拟退火算法的原位DNA微阵列合成优化方案研究
Qizhen Zhu,Hengyu Li,Kun Bi et al.
Qizhen Zhu et al.
Introduction: DNA microarray synthesis enables the large-scale and precise generation of DNA sequences for genomic research, data storage, and synthetic biology. However, the order of nucleotide addition significantly aff...
Network Pharmacology and Multi-omics Investigation of Yiqi Huoxue Formula's Molecular Mechanisms in Treating Endometriosis [0.03%]
益气活血方治疗子宫内膜异位症的网络药理学及多组学研究
Dongyi Shen,Panwei Hu,Jianting Lao et al.
Dongyi Shen et al.
Introduction: Endometriosis (EMs), a prevalent disorder characterized by pelvic pain and infertility, affects numerous bodily systems and markedly diminishes life quality. Yiqi Huoxue formula (YQHXF) has demonstrated prom...
The Potential Mechanisms of Total Flavonoids of Drynaria roosii Nakaike in the Treatment of Ovariectomized Osteoporotic Rats through the SDF-1/CXCR4 Axis and BMSCs [0.03%]
干燥卷柏总黄酮通过SDF-1/CXCR4轴及BMSCs改善卵巢切除绝经后骨质疏松症大鼠的机制研究
Chang Tan,Shibo Cong,Jiajia Zhang et al.
Chang Tan et al.
Introduction: The aim of this study was to investigate the potential mechanisms and therapeutic effects of Total Flavonoids of Drynaria roosii Nakaike (TFRD) on osteoporotic rats following ovariectomy, through modulation ...
CDK1 Signaling in Cancer Treatment: Advances in AI-based Strategies and Tools for New Cancer Drug Discovery [0.03%]
CDK1信号通路在癌症治疗中的作用：基于人工智能的新抗癌药物发现策略及工具研究进展
Rajesh Basnet,Yujian Wu,Zhaoming Liu et al.
Rajesh Basnet et al.
Cyclin-Dependent Kinases (CDKs) are proteins that help control the cell cycle. They are considered potential targets for cancer treatment because they are often found at higher levels in cancer tissues than in normal tissues, and their pres...
Network Pharmacology Analysis of Chinese Patent Medicine Zishen Yutai Pills Treating Recurrent Spontaneous Abortion and In Vitro Validation [0.03%]
滋肾育胎丸治疗复发性自然流产的网络药理学分析及体外验证
Jiewen Zhou,Tingting Chen,Xiufei Pang et al.
Jiewen Zhou et al.
Introduction: This study aims to assess the therapeutic mechanisms of Zishen Yutai Pills (ZYP) in treating recurrent spontaneous abortion (RSA) using network pharmacology analysis and in vitro validation of the molecular ...
Exploring the Anti-Rheumatoid Arthritis Inflammatory Mechanism of Shikonin Based on Network Pharmacology and Experimental Validation [0.03%]
基于网络药理学和实验验证探究北豆根抗类风湿关节炎的炎症机制
Yong-Gang Wu,Jing Jiang,Meng-Ying Jiang et al.
Yong-Gang Wu et al.
Introduction: Shikonin (SKN) is known for its anti-inflammatory effects; however, the molecular mechanisms underlying its therapeutic action in rheumatoid arthritis (RA) remain unclear. This study aimed to investigate the...
Network Pharmacology-Based Prediction of the Mechanistic Targets of CHKG in Treating Postpartum Hemorrhage [0.03%]
基于网络药理学预测CHKG治疗产后出血的机制靶点
Yi Gu,Xiaoxiao Ke,Tong Zhu et al.
Yi Gu et al.
Introduction: Chan-Hou-Kang-Gao (CHKG) is a classical traditional Chinese medicine (TCM) formula widely used to promote uterine involution and manage postpartum hemorrhage (PPH). However, the pharmacological basis and mol...
Lingguizhugan Decoction Attenuates Angiotensin II-Induced Cardiac Hypertrophy Through the LITAF Signaling Pathway [0.03%]
苓桂术甘汤通过LITAF信号通路抑制血管紧张素Ⅱ诱导的心脏 hypertrophy
Xiang Wang,Shaoyun Yue,Ting Yao et al.
Xiang Wang et al.
Objective: Lingguizhugan Decoction (LGZGD), a traditional Chinese herbal prescription with recognized efficacy in heart failure, has an unclear mechanism against cardiac hypertrophy. This study investigated its protective...
Integrating Network Pharmacology with In Vitro Experiments Reveals Ferroptosis as a Key Mechanism Underlying Shikonin's Anticancer Activity in HCC [0.03%]
网络药理学与体外实验结合揭示了血红素诱导肝癌细胞坏死的新型抗肿瘤作用机制
Nan Zhang,Wenjing Zhang,Yong Li et al.
Nan Zhang et al.
Introduction: Shikonin, a traditional Chinese medicine monomer, exhibits potential anticancer activity. An expanding body of literature indicates that targeting ferroptosis signaling pathways can elicit antitumor effects ...
Deciphering the Metabolic Mechanisms of Damp Retention in the Middle-Jiao Syndrome using High-throughput UPLC-Q-TOF-MS [0.03%]
基于高通量UPLC-Q-TOF-MS的中焦湿滞证代谢机制阐释研究
Na Li,Tongyan Zhu,Jianhui Chen et al.
Na Li et al.
Background: Damp retention in the middle-jiao syndrome (DRMS), a common manifestation in Traditional Chinese Medicine (TCM), results from stagnation of damp pathogens in the middle jiao and impaired transport of food and ...