Min Li,Xi-Jie Wang,Qi Zhao et al.
Min Li et al.
Bufalin is one of the main pharmacological and toxicological components of Venenum Bufonis and many traditional Chinese medicine preparations. The cardiotoxicity clearly limits its application to patients living in countries. Hence, an inve...
Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy [0.03%]
基于网络药理学策略揭示参附汤抗心力衰竭的协同机制
Yan-Wen Xu,Zhen-Dong Xu,Rui An et al.
Yan-Wen Xu et al.
The present study was designed to investigate the targets and synergistic mechanism of Shenfu Decoction (SFD) in the treatment of heart failure. A heart failure animal models was established to evaluate the pharmacological effects of SFD fo...
Mei Tian,Lin-Nan Li,Rui-Rong Zheng et al.
Mei Tian et al.
Traditional Chinese medicine (TCM) has been paid much attentions due to the prevention and treatment of steroid hormone disorders. Ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae), is one of the most valuable herbs in complementa...
Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells [0.03%]
肺腺癌细胞中Nagilactone E通过活化c-Jun促进PD-L1表达
Yu-Chi Chen,Mu-Yang Huang,Le-Le Zhang et al.
Yu-Chi Chen et al.
Nagilactone E (NLE), a natural product with anticancer activities, is isolated from Podocarpus nagi. In this study, we reported that NLE increased programmed death ligand 1 (PD-L1) expressions at both protein and mRNA levels in human lung c...
The ethyl acetate extraction of Pileostegia tomentella (ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis [0.03%]
拟顶蘑菇乙酸乙酯萃取物通过诱导经典凋亡途径发挥抗H1299细胞增殖作用
Qiu-Mei Fan,Wen-Tong Zhao,Renyikun Yuan et al.
Qiu-Mei Fan et al.
Lung cancer is the leading cause of cancer death and the most common malignant tumor, the long-term survival of which has stagnated in the past several decades. Pileostegia tomentella Hand. Mazz is a traditional Chinese medicine called "Zho...
Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota [0.03%]
三七总皂苷通过重塑肠道菌群抑制结肠炎相关性结直肠癌的发展
Ling Chen,Man-Yun Chen,Li Shao et al.
Ling Chen et al.
Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethan...
GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy [0.03%]
GL-V9通过影响JNK2相关自噬逆转肝癌细胞中多柔比星耐药性
Yue Yang,Yan Liao,Yan-Ping Gui et al.
Yue Yang et al.
Adriamycin resistance in HCC seriously hinders the treatment of patients, it is necessary to investigate the mechanisms. Autophagy is involved in adriamycin resistance and JNK2 is related to autophagy. However, whether JNK2 inducing drug re...
In vitro antitumor effect of cucurbitacin E on human lung cancer cell line and its molecular mechanism [0.03%]
瓜尔酸E体外抗肺癌细胞作用及机制研究
Si-Yuan Jing,Zi-Dan Wu,Tie-Hua Zhang et al.
Si-Yuan Jing et al.
Cucurbitacin E (CuE) is previously reported to exhibit antitumor effect by several means. In this study, CuE acted as a tyrosine kinase inhibitor interfering with the epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/M...
Jin-Jian Lu,Yi-Tao Wang
Jin-Jian Lu
Sangguayin preparation prevents palmitate-induced apoptosis by suppressing endoplasmic reticulum stress and autophagy in db/db mice and MIN6 pancreatic β-cells [0.03%]
桑干预制备通过抑制内质网应激和自噬防治db/db小鼠及MIN6胰岛β细胞棕榈酸诱导的凋亡
Qi-Chang Xing,Xiang Liu,Wei Li et al.
Qi-Chang Xing et al.
Sangguayin preparation (SGY-P) is refined from the traditional Chinese medicinal compound Sangguayin, which "clears heat and promotes fluid" and "tonifies kidney and spleen" for "Xiaoke", commonly known as 'Diabetes mellitus' in clinics. Pr...