Potential of ginsenoside Rh2and its derivatives as anti-cancer agents [0.03%]
人参皂苷Rh2及其衍生物作为抗肿瘤药物的潜能
Keke Li,Zhongyu Li,Lei Men et al.
Keke Li et al.
As a steroid skeleton-based saponin, ginsenoside Rh2 (G-Rh2) is one of the major bioactive ginsenosides from the plants of genus Panax L. Many studies have reported the notable pharmacological activities of G-Rh2 such as anticancer, antiinf...
Construction and heterologous expression of the di-AFN A1 biosynthetic gene cluster in Streptomyces model strains [0.03%]
二聚AFN A1生物合成基因簇在链霉菌模式菌株中的构建及其异源表达
Weijia Wei,Wenzhao Wang,Chao Li et al.
Weijia Wei et al.
Natural cyclohexapeptide AFN A1 fromStreptomyces alboflavus 313 has moderate antibacterial and antitumor activities. An artificial designed AFN A1 homodimer, di-AFN A1, is an antibiotic exhibiting 10 to 150 fold higher biological activities...
Xenopus GLP-1-based glycopeptides as dual glucagon-like peptide 1 receptor/glucagon receptor agonists with improved in vivo stability for treating diabetes and obesity [0.03%]
基于非洲爪蟾GLP-1的糖肽作为改善了体内稳定性的双重胰高血糖素样肽-1受体/胰高血糖素受体激动剂，用于治疗糖尿病和肥胖症
Qiang Li,Qimeng Yang,Jing Han et al.
Qiang Li et al.
Peptide dual agonists toward both glucagon-like peptide 1 receptor (GLP-1R) and glucagon receptor (GCGR) are emerging as novel therapeutics for the treatment of type 2 diabetes mellitus (T2DM) patients with obesity. Our previous work identi...
Ribai Yan,Youhong Niu,Yuheng Liu et al.
Ribai Yan et al.
For the purpose of seeking new antibiotics, researchers usually modify the already-existing ones. However, this strategy has been extensively used and is close to its limits, especially in the case of aminoglycosides, and it is difficult to...
Rapid identification of stigmastane-type steroid saponins from Vernonia amygdalina leaf based on α-glucosidase inhibiting activity and molecular networking [0.03%]
基于α-葡萄糖苷酶抑制活性和分子网络的Vernonia amygdalina叶中甾体皂苷的快速鉴定（注：原文中的"stigmastane-type steroid saponins"较为专业，直译为"豆甾烷型甾体皂苷"，但在中文文献中通常直接称为“甾体皂苷”，因此在标题翻译中简化为“甾体皂苷”以符合中文表达习惯。）
Juanjuan Gao,Mengling Zhao,Shujun Shan et al.
Juanjuan Gao et al.
Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines, especially Vernonia amygdalina, a famous nature medicine for the treatment of tonsillitis, diabetes, pneumoni...
Xiaobei Cheng,Caili Zhao,Zhiwei Jin et al.
Xiaobei Cheng et al.
Atherosclerosis (AS) is an invisible killer among cardiovascular diseases (CVD), which has seriously threatened the life of quality. The complex pathogenesis of AS involves multiple interrelated events and cell types, such as macrophages, e...
Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents [0.03%]
parthenolide及其衍生物的结构改造作为抗肿瘤剂的近期进展
Xingchen Liu,Xiaobing Wang
Xingchen Liu
Parthenolide (PTL) is a sesquiterpene lactone derived from medicinal plant feverfew (Tanacetum parthenium). Recent studies have demonstrated that it has multiple pharmacological activities, especially in the treatment of various hematologic...
A systematic review on the safety of Psoraleae Fructus: potential risks, toxic characteristics, underlying mechanisms and detoxification methods [0.03%]
补骨脂的安全性系统评价：潜在风险、毒性特征、作用机制及解毒方法
Zhuo Shi,Jing Gao,Jinchao Pan et al.
Zhuo Shi et al.
Psoraleae Fructus (PF) is an important traditional herbal medicine with a long history of clinical application. It is widely used to treat various diseases, such as osteoporosis, leucoderma and diarrhea. As a traditional nontoxic herb, it h...
Sustainable utilization of precious Chinese medicines: challenges and the road ahead [0.03%]
珍贵中药的可持续利用：挑战与展望
Jiahao Gong,Haiying Li,Jianguang Xu et al.
Jiahao Gong et al.
Genome mining of fungal globin-like enzymes for catalyzing the synthesis of linear terpenes [0.03%]
挖掘矿化真菌类血红蛋白样酶催化的线性萜合成
Li Liu,Xiwei Chen,Yi Zou
Li Liu
Genome mining for the search and discovery of two new globin-like enzymes, TriB fromFusarium poae and TutaA from Schizophyllum commne, are involved in the synthesis of two linear terpenes tricinonoic acid (1) and 2-butenedioic acid (3). Bot...