Recent Advancement of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis- A Review [0.03%]
近期粪便微生物移植治疗溃疡性结肠炎的研究进展-综述评论类文章
Yiting Lin,Peiru Wang,Xi Hu et al.
Yiting Lin et al.
Fecal Microbiota Transplantation (FMT) involves the transfer of gut microbiota from healthy donors to recipients, aiming to reestablish microbial equilibrium within the gastrointestinal tract. The human gut harbors a complex and diverse mic...
Discovery of Furan-tethered Triazolothiadiazoles and Triazolothiadiazines as Potent Tyrosinase Inhibitors for the Treatment of Skin Diseases: Insights from Kinetics Data and Computational Modeling [0.03%]
一类新的治疗皮肤病的高效酪氨酸酶抑制剂——噻二唑并三氮唑类化合物的设计合成及构效关系研究：动力学分析与计算模拟
Majid Khan,Atta Ullah,Sobia Ahsan Halim et al.
Majid Khan et al.
Introduction: Tyrosinase, a copper-containing enzyme, is responsible for melanin production, and its overactivity can lead to hyperpigmentation. Methods: ...
Participation of MDM2 in Pro-Apoptotic and Androgen Receptor-Degrading Potency of Selected Steroid and Terpenoid Derivatives [0.03%]
MDM2在选择性类固醇和萜烯衍生物促凋亡及雄激素受体降解作用中的参与效应
Alexander Y Misharin,Alexander V Veselovsky,Vladimir A Zolottsev
Alexander Y Misharin
This review aims to highlight anti-proliferative, pro-apoptotic, and androgen receptor-degrading activity of selected steroid and terpenoid derivatives in cancer cells, primarily in prostate cancer cells. Steroid and terpenoid derivatives (...
Hybrids/Conjugates/Chimera Drugs-Antimicrobial Hybrids: Antibiotics, Antifungals, Antituberculars, Antimalarials [0.03%]
杂交抗菌药-抗微生物杂交抗生素、抗真菌药、抗结核病药和抗疟疾药
Abraham Nudelman
Abraham Nudelman
Antimicrobial hybrids are compounds that can inhibit, stop the growth of, or kill microorganisms, including bacteria, fungi, and parasites. Antibiotics, a subset of an-timicrobial agents, specifically target bacteria and include well-establ...
Causal Relationships Between Modifiable Risk Factors and Gastroesophageal Reflux Disease: A Two-Sample Mendelian Randomization Study [0.03%]
基于孟德尔随机化方法探究贲门失缓症与可改变风险因素之间的因果关系
Zhongqiu Zhou,Gang Shen,Wenying Zhou et al.
Zhongqiu Zhou et al.
Introduction: Gastroesophageal reflux disease (GERD) is a prevalent digestive disorder, yet the causal roles of modifiable risk factors remain unclear. This study aims to investigate the causal relationships between 28 mo...
Synthesis, Antiproliferative Activity, ADME Profiling, and Docking Studies of Novel 1, 2, 3-Triazole Derivatives of 2-Amino and 2-Mercaptobenzoxazole [0.03%]
2-氨基和2-巯基苯并恶唑衍生物新型1,2,3-三氮唑衍生物的合成、抗增殖活性、ADME分析及分子对接研究
Robert Ostrički,Anja Rakas,Vesna Rastija et al.
Robert Ostrički et al.
Introduction: Benzoxazole is a privileged scaffold with diverse biological activities, and its hybridization with a 1,2,3-triazole ring can improve affinity and efficacy. This study aimed to synthesize novel 1,2,3-triazol...
Targeted Anti-Inflammatory Effects of Chloramphenicol via TLR4 Inhibition in Postoperative Hemorrhoid Treatment: A Clinico-Computational Cohort Study [0.03%]
氯霉素通过TLR4抑制在术后痔疮治疗中的靶向抗炎作用：临床计算队列研究
S Shityakov,N S Lubinets,E Skorb et al.
S Shityakov et al.
Introduction: Postoperative hemorrhoidectomy wounds are prone to inflammation and microbial infection due to their anatomical location, necessitating effective therapeutic strategies. Chloramphenicol (CHL) is a broad-spec...
New 4-Benzenesulfonamide Derivatives of Pyrazolo[1,5- a] [1, 3, 5]triazine as Purine Bioisosteres: Development, Synthesis, and Anticancer Perspective [0.03%]
用于取代嘌呤的新的含苯磺酰胺基吡唑三嗪衍生物：开发、合成及抗肿瘤研究视角
Ivan Semenyuta,Stepan Pilyo,Bohdan Demydchuk et al.
Ivan Semenyuta et al.
Introduction: Seven new 4-[2-(dichloromethyl)pyrazolo[1,5-a][1,3,5]triazine derivatives were investigated for anticancer activity, possible molecular mechanisms of anticancer action, and ADMET properties. ...
Polysaccharides from Sepia Esculenta Ink Promote Apoptosis via Inhibition of Autophagy in Cisplatin-exposed Triple-Negative Breast Cancer Cells [0.03%]
墨乌贼墨汁多糖通过抑制自噬促进顺铂诱导的三阴性乳腺癌细胞凋亡
Wei Xiao,Zhen Lin,Ping Luo et al.
Wei Xiao et al.
Introduction: Sepia Ink Polysaccharide (SIP) is a well-characterized, marinederived glycosaminoglycan with demonstrated multifunctional properties; however, its pharmacological mechanisms remain unclear. This study aims t...
Wassan Nori,Zina Abdullah Hussein,Roaa Mokram Hamed et al.
Wassan Nori et al.
Introduction: Long COVID-19 (LC) is a condition that follows SARS-CoV- -2, an acute infection defined by persistent fatigue, dyspnea, and impaired cognitive function. LC presents a complex array that imposes ongoing chall...