COPZ2 and KDELR3 are Linked to Stromal Inflammation and Metabolic Reprogramming in Osteoarthritis [0.03%]
copz2和kdelr3与骨关节炎的间质炎症和代谢重组有关
Cheng Wang,Juan Xiao,Hanyu Wang et al.
Cheng Wang et al.
Introduction: Fibroblasts are important contributors to Osteoarthritis (OA) pathogenesis, but the molecular features associated with their pathogenic activation remain incompletely defined. ...
A Multi-Method Approach to Investigate the Toxicity of Aristolochic Acid on Upper Tract Urothelial Carcinoma [0.03%]
探讨 Aristocholic酸对尿路上皮癌上行毒性多方法研究
Yidong Zhu,Xiaoyi Jin,Jun Liu et al.
Yidong Zhu et al.
Introduction: Exposure to aristolochic acid (AA) has been strongly linked to the development of upper tract urothelial carcinoma (UTUC), but the precise molecular mechanisms driving AA-associated carcinogenesis remain unc...
The Novel Prognostic Biomarker MAPK12 Promotes Migration, Proliferation, and Invasion in Head and Neck Squamous Cell Carcinoma [0.03%]
MAPK12：一种新的头颈鳞癌预后生物标志物，可促进肿瘤细胞迁移、增殖和侵袭
Yuxi Cheng,Tianyi Liu,Manyu Li et al.
Yuxi Cheng et al.
Background: The prognosis and survival rate of patients with head and neck squamous cell carcinoma (HNSCC) remain a serious public health concern. Therefore, elucidation of the underlying mechanisms responsible for the bi...
Exploring the Mechanism of Curcumin in the Treatment of Gastric Cancer based on Network Pharmacology, Molecular Dynamics Simulation, and In Vitro Experimental Verification [0.03%]
基于网络药理学、分子动力学模拟及体外实验验证研究姜黄素治疗胃癌的机制
Hui Xu,Quan Fang,Chao Wang et al.
Hui Xu et al.
Introduction: Gastric Cancer (GC) is still one of the leading causes of cancer-related deaths worldwide. Curcumin, a natural polyphenol found in turmeric, has been reported to have anti-tumor properties. However, the mech...
Enhancing Deep Learning Chest Disease Diagnosis through Adversarial Training for Robust and Reliable Medical Imaging [0.03%]
基于对抗训练的稳健可靠的胸部疾病深度学习诊断方法研究
Ayah Fareed Al Omar,Shadi A Aljawarneh
Ayah Fareed Al Omar
Introduction: Chest X-ray imaging is widely used for the diagnosis of thoracic diseases; however, developing reliable automated systems remains challenging due to variability in imaging conditions and disease presentation...
Cannabis and Synthetic Cannabinoids in the Context of Cancer: A Review of Current Evidence and Future Directions [0.03%]
大麻和合成大麻素在癌症背景下的现状及未来方向——综述当前证据
Laith Al-Eitan,Aqdas Mansour,Diana Almahdawi et al.
Laith Al-Eitan et al.
Cannabinoids are now being explored for their broader role in cancer treatment and not solely as agents for symptom relief. These compounds, which are derived from Cannabis sativa plants and synthetic analogs, are well known for their uniqu...
Computational Investigation of Molnupiravir Synthetic Intermediates: DFT and Molecular Simulation [0.03%]
莫努匹拉韦合成中间体的计算研究：DFT和分子模拟
Jianjun Zhou,Yanni Wang,Huanhuan Xia et al.
Jianjun Zhou et al.
Background: SARS-CoV-2's continual mutation poses a major global health threat, underscoring the urgent need for new antivirals. Objective: ...
Maxim Shkurnikov,Alexander Tonevitsky
Maxim Shkurnikov
Introduction: Exosomes, extracellular vesicles of 30-150 nm generated via fusion of multivesicular bodies with the plasma membrane, have evolved from poorly characterized cellular byproducts into a promising platform for ...
Oxymatrine Synergizes with 5-fluorouracil to Inhibit the Proliferation of A549 Cells by Targeting APE1 [0.03%]
氧化苦参碱通过靶向APE1增强氟尿嘧啶抑制A549细胞增殖的作用
Guofang Zeng,Fei Luo,Qiaoli Zeng et al.
Guofang Zeng et al.
Objective: Resistance to 5-fluorouracil (5-FU) necessitates its administration in combination with other drugs to enhance the clinical outcome. Oxymatrine (OMT) exhibits antitumor and anti-inflammatory activities. This st...
Synthesis, Characterization, Anti-Proliferative Activity, Cell Cycle Analysis, and Annexin V-FITC Apoptosis Study of New Thiazole Derivatives [0.03%]
新型噻唑衍生物的合成、表征、抗增殖活性及细胞周期分析和Annexin V-FITC凋亡研究
Hossa F Alshareef
Hossa F Alshareef
Objective: We herein synthesized a new series of thiazole derivatives as anti- breast cancer agents. Methods: Different thiazole deriva...