Alessia Catalano
Alessia Catalano
Selenium Enhances Osteogenic Differentiation and Mineralization in Human Osteoblasts: Implications for Bone Health and Metabolism [0.03%]
硒通过促进人成骨细胞成骨分化和矿化对骨骼健康和代谢的影响
Erhan Sahin,Mahmoud Arafat,Ayse Tansu Koparal
Erhan Sahin
Introduction: Sodium Selenite (NaSe) is a molecule with various biological activities. Bone fractures and osteoporotic diseases are increasingly common health issues, prompting the search for alternative treatments. There...
Uridines Modified with Sulfur or Selenium in U-G Wobble Pairs Matter for tRNA Function [0.03%]
tRNA中U-G wobble对中的硫化或硒化尿苷影响其功能
Katarzyna Kulik,Barbara Nawrot
Katarzyna Kulik
Transfer RNAs (tRNAs) are ubiquitous in cells and are essential for the translation of genetic information from messenger RNA (mRNA) into proteins in all three domains of life. They act as adaptors that decode mRNA codons via their anticodo...
Romosozumab's Effect on Bone Mineral Density in Patients with Osteoporosis: A Systematic Review and Meta-Analysis [0.03%]
核因子κB受体活化剂O诱导蛋白(OPG)抗体Denosumab对骨密度的影响：系统评价和 meta分析
Hooman Yahyazadeh,Tahereh Farkhondeh,Abolfazl Bagherifard et al.
Hooman Yahyazadeh et al.
Introduction: One of the most effective osteoanabolic drugs for treating osteoporosis is romosozumab, which was developed as a consequence of growing knowledge of the Wnt signaling system. This review explored how romosoz...
Diverse Development Approaches for Xanthine Oxidase Inhibitors: Synthetic Chemistry, Natural Product Chemistry, and Drug Repositioning [0.03%]
黄嘌呤氧化酶抑制剂的多样化研发策略：合成化学、天然产物化学和老药新用
Zhihua Xing,Wen Jiang,Yue Xu et al.
Zhihua Xing et al.
Xanthine oxidase (XOD) plays a crucial role in the biosynthesis of uric acid, and inhibiting its activity can effectively reduce the production of uric acid at its source. Currently, clinically used xanthine oxidase inhibitors (XODIs), such...
Investigating the Causal Role of Neurotrophic Factors in Low Back Pain and Sciatica: A Mendelian Randomization Study [0.03%]
神经生长因子在腰痛和坐骨神经痛发病机制中的作用：孟德尔随机化研究
Feixiang Lin,Wei He
Feixiang Lin
Background: Low back pain (LBP) and sciatica are among the most prevalent musculoskeletal disorders, leading to significant disability and an economic burden. Neurotrophic factors, including nerve growth factor (NGF), bra...
A Comprehensive Analysis of the ITIH Family Across Multiple Cancer Types and an Initial Investigation of ITIH1 in Gastric Cancer [0.03%]
ITIH家族的综合分析及其成员蛋白ITIH1在胃癌中作用的初步研究
Qiangqiang Zhong,Baokang Zhao,Xiao She et al.
Qiangqiang Zhong et al.
Introduction: The ITIH family, crucial for extracellular matrix stability and cancer progression, is underexplored in multi-omic profiles and immune microenvironments; this study analyzes their roles across cancers and IT...
Post-marketing Safety Surveillance of Drug-induced Dementia: Utilizing Signal Detection and Mendelian Randomization in Spontaneous Reports [0.03%]
基于自发报告的药物致痴呆上市后安全监测：利用信号检测和孟德尔随机化筛选潜在致病因素
Yan Chen,Chen Li,Yinhui Yao et al.
Yan Chen et al.
Objective: Many medications associated with an increased risk of dementia do not have adequate warning labels, leading to a significant underestimation of their potential dangers. This study aims to leverage the FAERS dat...
Single-Cell Maps Reveal Novel Mechanisms of Ferroptosis and Biomarkers in Diabetic Nephropathy [0.03%]
单细胞图谱揭示糖尿病肾病铁死亡新机制及生物标志物
Yueyi Zhou,Weilin Chen,Dan Li et al.
Yueyi Zhou et al.
Objective: Diabetic nephropathy (DN) is the main cause of renal failure due to its complexity and difficulty in prevention. The purpose of our study is to screen potential biomarkers of DN at the single-cell level and rev...
An Advanced Network Pharmacology Study Reveals the Multi-Pathway and Multi-Gene Regulatory Mechanism of Jinbai Heat-clearing Prescription in HPV-induced Cervical Cancer via Molecular Docking and Microarray Data Analysis [0.03%]
基于分子对接和芯片数据的网络药理学研究金白清热方多通路、多基因调控机制及其抗HPV感染宫颈癌的作用机制
Sui Liu,Zixiao Jiang,Junlei He et al.
Sui Liu et al.
Introduction: Cervical cancer, primarily driven by high-risk human papillomavirus (HPV) infection, remains a global health challenge due to limited therapeutic efficacy and adverse effects of conventional treatments. Jinb...