Ferroptosis and Its Crosstalk with Other Cell Death Modes in Ischemic Stroke [0.03%]
缺血性卒中中铁死亡及其与其他细胞死亡方式的交叉反应
Huimin Zhu,L I Zhou,Weifeng Yu et al.
Huimin Zhu et al.
Ischemic stroke is the most common cerebrovascular disease. The core pathological mechanism underlying its neurological deficits is the massive neuronal death triggered by cerebral ischemia, hypoxia, and reperfusion injury following a sudde...
Integrative Analysis Reveals BPTF, COL1A1, and COL4A2 as Fibroblast-Related Biomarkers Associated with Immune Infiltration in Ovarian Cancer [0.03%]
整合分析揭示BPTF、COL1A1和COL4A2为与卵巢癌免疫浸润相关的成纤维细胞标志物
Haixia Wang,Zongtao Li,Jianmei Xia et al.
Haixia Wang et al.
Introduction: As fibroblasts constitute a crucial component of the tumor microenvironment (TME), identifying fibroblast-related genes may help elucidate the mechanisms underlying ovarian cancer (OC) progression. ...
Phenylalanine Hydroxylase as a Prognostic Marker in Pancreatic Cancer: Insights into Tumor Metabolism and Immune Microenvironment [0.03%]
苯丙氨酸羟化酶作为胰腺癌预后标志物的潜在作用：肿瘤代谢和免疫微环境的新见解
Yi Liu,Duan Yan,Fan Liu et al.
Yi Liu et al.
Introduction: Tumor metabolism-related genes participate in tumor metabolic reprogramming and reshape the tumor microenvironment (TME), thereby influencing tumor progression and patient prognosis. However, studies investi...
Pharmacological Targeting of NRF2 Represents a Promising Therapeutic Approach for Pyroptosis-Related Non-Alcoholic Fatty Liver Disease [0.03%]
药理学靶向NRF2代表了治疗与焦亡相关的非酒精性脂肪肝病的一种有希望的治疗途径
Yinggang Zhang,Pengfei Liu,Ying Guo et al.
Yinggang Zhang et al.
Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological condition characterized by the accumulation of fat within hepatocytes in the absence of excessive alcohol consumption or other identifiable causes of liver injury. As a dise...
Unlocking the Prognostic Power of the m-CALLY Index in Cardiovascular-Kidney-Metabolic Syndrome [0.03%]
解锁心血管-肾脏-代谢综合征的m-CALLY指数预测能力
Jingxian Sun,Guangyu Du,Daikang Xu et al.
Jingxian Sun et al.
Introduction: Cardiovascular-Kidney-Metabolic (CKM) syndrome is a multi- -system disorder driven by chronic inflammation and immune-nutritional imbalances. This study aimed to evaluate the prognostic value of the modified...
Ferritinophagy-Related Genes in Breast Cancer: Insights from Multi-Omics Analysis [0.03%]
乳腺癌中铁蛋白吞噬相关基因的多组学分析见解
Wen Luo,Peng Xu,Hao Wu et al.
Wen Luo et al.
Introduction: Breast cancer (BRCA) remains a major health burden. Ferritinophagy, a selective form of autophagy regulating iron homeostasis, has been linked to tumor progression. This study aims to explore ferritinophagy-...
Research Progress on Natural Products and Synergistic Nanostrategies for Targeting Ferroptosis in Osteosarcoma [0.03%]
靶向促进骨肉瘤铁死亡的天然产物与协同纳米策略的研究进展
Chao Chen,Qianlin Zuo,Qicong He et al.
Chao Chen et al.
Emerging evidence suggests that ferroptosis, a unique iron-dependent form of regulated cell death driven by lipid peroxidation and morphologically distinct from apoptosis or necrosis, plays a vital role in the pathophysiological progression...
Revealing Antihypertensive Drugs for Reducing NAFLD Risk: Genetic Evidence from a Mendelian Randomization Study [0.03%]
基于孟德尔随机化研究的降压药降低非酒精性脂肪肝风险的遗传证据
Kanglong Zhang,Ling Guo,Yiming Gan et al.
Kanglong Zhang et al.
Background: Longstanding observational work has associated Nonalcoholic Fatty Liver Disease (NAFLD) with hypertension and suggested that antihypertensive therapy may slow NAFLD progression. However, confounding and revers...
Identification of Diagnostic Biomarkers Related to Oxidative Stress in Rheumatoid Arthritis [0.03%]
与类风湿性关节炎氧化应激相关的诊断生物标志物的鉴定
Hao Tang,Wei Ji,Yan Liu et al.
Hao Tang et al.
Background: This study aimed to identify oxidative stress-related genes as potential diagnostic biomarkers for rheumatoid arthritis (RA). Methods: ...
Mechanistic Insights into Ginkgo Biloba Extract's Anti-Inflammatory Effects in COPD: Regulation of Th1/Th2 Balance via the p38 MAPK Pathway [0.03%]
从机制上了解银杏提取物在慢性阻塞性肺疾病中抗炎作用：通过p38丝裂原活化蛋白激酶通路调节Th1/Th2平衡
Pengfei Zhang,Lijun Liao,Xiaojun Dong et al.
Pengfei Zhang et al.
Objective: To investigate the anti-inflammatory and therapeutic effects of Ginkgo biloba extract (GBE) on chronic obstructive pulmonary disease (COPD), and to elucidate the underlying molecular mechanism by which GBE modu...