Azole Antifungals Under Pressure: Therapeutic Challenges and Multifaceted Resistance Mechanisms [0.03%]
唑类抗真菌药面临压力：治疗挑战与多重耐药机制
Andre L S Santos,Lívia S Ramos,Thais P Mello et al.
Andre L S Santos et al.
Fungal infections have increased markedly in both incidence and severity over recent decades, driven in part by the emergence of novel pathogenic species harboring sophisticated resistance mechanisms against commonly used antifungal agents....
Circulating proteins and bone mineral density: A Proteome-Wide Mendelian Randomization Study [0.03%]
循环蛋白与骨密度：一种蛋白质组范围的孟德尔随机化研究
Tianyi Wang,Liu Liu,Ruiying Han et al.
Tianyi Wang et al.
Introduction: Current osteoporosis medications often prove ineffective for various reasons. Alongside optimizing available agents, new genetic targets should be proposed for drug development. Mendelian randomization (MR) ...
Beneficial Role of Zinc in Metabolic Syndrome: Understanding the Underlying Pathophysiological Mechanisms [0.03%]
锌在代谢综合征中的有益作用：了解其潜在的病理生理机制
Abdullah Al Lawati,Emir Ličina,Patrycja Głoćko et al.
Abdullah Al Lawati et al.
Metabolic syndrome (MetS) is a complex disorder that comprises metabolic abnormalities such as central obesity, insulin resistance, dyslipidemia, and hypertension. Eventually, MetS leads to type 2 diabetes (T2DM) and increases the risk of o...
Transcriptome-wide Association Studies Integrating Four Levels Identify Novel Targets for Idiopathic Pulmonary Fibrosis [0.03%]
整合四个层次的转录组关联研究发现特发性肺纤维化的新靶点
Jiaxin Shi,Linyou Zhang
Jiaxin Shi
Introduction: Idiopathic pulmonary fibrosis (IPF) is a kind of interstitial lung disease with a poor prognosis. Even though genome-wide association studies (GWAS) have identified numerous loci linked to IPF risk, the unde...
Expression of TCEAL2 is a Novel Prognostic Biomarker and Potential Therapeutic Target in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma [0.03%]
TCEAL2表达是一种新型生物标志物及潜在治疗靶点在宫颈鳞癌和宫内膜腺癌中的作用研究
Jinyuan Li,Zhen Ye,Yuhong Gan et al.
Jinyuan Li et al.
Background: Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are major gynecological malignancies, causing significant cancer-related deaths in women. Current treatments yield poor outcomes, with a ...
Expression, Prognostic Value, and Biological Function of CENPM in Colon Adenocarcinoma [0.03%]
结肠腺癌中CENPM的表达、预后价值及生物学功能
Zhiming Cai,Zhenrong Yang,Qian Yu et al.
Zhiming Cai et al.
Introduction: Centromere protein M (CENPM), a member of the CENP family, is correlated with several malignancies, but its role in colon adenocarcinoma (COAD) is unclear. This study aims to explore the expression, prognost...
"Next-in-class" GLP-1R Danuglipron- and Lotiglipron-like Agonists: A Patent Review (2020-2024) [0.03%]
GLP-1受体部分激动剂丹谷利普龙和罗替利普龙专利回顾（2020-2024）
Elena V Tolkacheva,Alexandr Yu Saliev,Tagir L Salakhov et al.
Elena V Tolkacheva et al.
Background: GLP-1 receptor peptide agonists have revolutionized type 2 diabetes mellitus and obesity treatment, primarily through injection-based therapies. Small-molecule GLP-1 receptor agonists allow oral administration...
Atta-Ur Rahman
Atta-Ur Rahman
Decoding PRTFDC1's Role in Lung Adenocarcinoma: From Gene Expression to Clinical Implications [0.03%]
PRTFDC1在肺腺癌中的作用机制及临床意义研究从基因表达到临床意义
Jian Yao,Qiang Zhang,Chunhe Zhong et al.
Jian Yao et al.
Introduction: This study aims to elucidate the role of Phosphoribosyl Transferase Domain Containing 1 (PRTFDC1) in Lung Adenocarcinoma (LUAD) through bioinformatics analysis and experimental validation, exploring its pote...
Salvage Structures, Known as Iron Chelating Agents, Acquired from the Nature and Matured in the Labs [0.03%]
从天然获取并在实验室完善的补救结构——螯合剂类化合物
Salime Lavian,Fatemeh Haddadi,Ehsan Farshadfar et al.
Salime Lavian et al.
Iron, as an essential element, plays a crucial role in ensuring the proper functioning of all living organisms. While the appropriate level of iron for the optimal functioning of organisms cannot be disregarded, an excessive amount of this ...