Apolipoprotein A1 and Lipoprotein(a) as Biomarkers for the "Penumbra Freezing" in Acute Ischemic Stroke: Insights From a Case-Control and Mendelian Randomization Study [0.03%]
载脂蛋白A1和Lp(a)作为急性缺血性卒中“半暗带冻结”的生物标志物：来自病例对照研究和孟德尔随机化研究的见解
Jianyu Liu,Zhiyao Xu,Yang Wen et al.
Jianyu Liu et al.
Introduction: "Penumbra freezing" aims to extend vascular recanalization treatment to acute ischemic stroke (AIS) patients beyond the standard time window by preserving the ischemic penumbra. Efficient biomarkers are cruc...
Mediating Effects of Plasma Metabolites in Inflammatory Protein-Lymphoma Causality: A Mendelian Randomization Study [0.03%]
炎性蛋白与淋巴瘤因果关系的中介代谢组学研究：孟德尔随机化研究
Yueru Ji,Xiaotong Gao,Li Liu et al.
Yueru Ji et al.
Introduction: Diffuse large B-cell lymphoma (DLBCL) pathogenesis is poorly understood, with limited causal evidence linking circulating inflammatory proteins (CIPs) and metabolites to disease risk. Observational studies f...
LncRNA HYMAI Promotes Endothelial Cell Autophagy via miR-19a-3p/ ATG14 to Attenuate the Progression of Coronary Atherosclerotic Disease [0.03%]
长链非编码RNA HYMAI通过miR-19a-3p/ATG14促进内皮细胞自噬以抑制冠状动脉粥样硬化性疾病进展
Shao Ouyang,Zhi-Xiang Zhou,Hui-Ting Liu et al.
Shao Ouyang et al.
Background: Coronary atherosclerotic disease (CAD), clinically manifesting as progressive coronary atherosclerosis (As), involves endothelial cell (EC) dysfunction. HYMAI may contribute to atherogenesis by acting on ECs, ...
The Role of Beta-Lactam Antibiotics in Reactive Oxygen Species Generation and Therapeutic Implications [0.03%]
β-内酰胺类抗生素在活性氧产生及治疗中的作用
Shibani Basu,Mario Valente,Bimal Krishna Banik
Shibani Basu
Reactive oxygen species (ROS) play a pivotal role in cellular damage and the signaling processes, with their production significantly influenced by antimicrobial agents such as β-lactam antibiotics. This review explores the dual role of β...
8-Hydroxyquinoline Derivatives as Drug Candidates for the Treatment of Alzheimer's Disease [0.03%]
8-羟基喹啉衍生物作为治疗阿尔茨海默病的药物候选物
Pedro F Bartolomeu,Isadora S Fortes,Aline R Zimmer et al.
Pedro F Bartolomeu et al.
Alzheimer's disease (AD) is the most prevalent form of dementia among older adults worldwide. Amidst several hypotheses to explain the pathobiology of the disease are biochemical indicators such as β-amyloid (Aβ) plaques; neurofibrillary ...
Identification of Microvascular Invasion-Related Biomarkers for Personalized Treatment of Hepatocellular Carcinoma [0.03%]
用于肝细胞癌个性化治疗的微血管浸润相关生物标志物识别研究
Wei Xiang,Xue Liu,Tingting Bao et al.
Wei Xiang et al.
Introduction: Hepatocellular Carcinoma (HCC) exhibits high recurrence rates, particularly when accompanied by Microvascular Invasion (MVI). We identified MVI-related biomarkers and established a prognostic model for perso...
Association between Serum Klotho Levels and Sarcopenia: Result from the NHANES (2011-2016) [0.03%]
血清类粘蛋白与 sarcopenia 关系的横断面研究（来源于 2011-2016 年 NHANES）
Ting Sun,Lu Liu,Xiaoqi Xie et al.
Ting Sun et al.
Introduction: Klotho is a multifunctional protein with anti-aging properties that plays a role in regulating vitamin D and phosphate metabolism. Sarcopenia is characterized by the loss of muscle mass and strength and is a...
Connexin 43: Roles in the Pathophysiology of Cardiovascular Diseases and Attractive Target for New Drugs [0.03%]
缝隙蛋白43在心血管疾病病理生理中的作用及作为新药靶点的潜力
Yijia Wu,Yixiong Zhan,Duoduo Zha et al.
Yijia Wu et al.
Connexin43 (Cx43), encoded by the GJA1 gene, plays a crucial role in the formation of hemichannels and the assembly of gap junctions between adjacent cells, facilitating the efficient transport of ions and small molecules. Increasingly stud...
The Potential Mechanism of Quercetin in Treating Diabetic Foot Ulcer Revealed by Network Pharmacology [0.03%]
网络药理学揭示檞皮素治疗糖尿病足溃疡的潜在机制研究
Liuwen Huang,Ran Ji,Wenxing Su et al.
Liuwen Huang et al.
Introduction: To identify the critical genes, biological mechanisms, and signaling pathways involved in the therapeutic effects of quercetin on diabetic foot ulcers using network pharmacology and molecular docking approac...
Evangelia Zacharioudaki,Maria Stella Trivyza,Marios Papasotiriou et al.
Evangelia Zacharioudaki et al.
Background: Endothelins are a family of vasoconstrictive peptides known for their high potency. They are mainly synthesized and secreted by the endothelial cells lining the blood vessels in response to various stimuli. Th...