Synthesis, Cytotoxicity Evaluation, and Molecular Dynamics of 4-Thiazolidinone Derivatives: A Potential Path to EGFR-Targeted Anticancer Therapy [0.03%]
4-噻唑烷酮衍生物的合成、细胞毒性评价及分子动力学模拟：EGFR靶向抗肿瘤药物研究的新途径
Tomasz Szostek,Dagmara Otto-Ślusarczyk,Michał A Dobrowolski et al.
Tomasz Szostek et al.
Introduction: Heterocyclic compounds remain cornerstones of contemporary drug discovery because their ring-embedded heteroatoms confer adaptable electronics, conformational flexibility, and a broad spectrum of biological ...
Investigating the Mechanisms of Mitochondrial Dysfunction in Ischemic Stroke and Predicting Therapeutics Through Machine Learning and Integrated Bioinformatics [0.03%]
通过机器学习和集成生物信息学研究缺血性卒中线粒体功能障碍机制及预测治疗手段
Chao Qi,Feng Dong,Kai Yang et al.
Chao Qi et al.
Introduction: Ischemic Stroke (IS) represents the most prevalent subtype of cerebrovascular disease, characterized by complex pathophysiological mechanisms that remain inadequately characterized, particularly concerning m...
Neuroinflammatory Human Brain Organoids Enable Comprehensive Drug Screening Studies: Fingolimod and its Analogues in Focus [0.03%]
神经炎症人类脑器官体实现全面的药物筛选研究：芬戈莫德及其类似物的研究焦点
Busra Acar,Nihan Aktas Pepe,Aleksandra Zivkovic et al.
Busra Acar et al.
Introduction: The absence of physiologically relevant models for neuroinflammatory brain disorders, such as multiple sclerosis (MS), highlights the need for improved drug screening platforms. To bridge this gap, this stud...
Side Chain Effects on the Lipophilicity-antimicrobial-toxicity Correlation of Greener 4-Alkoxy/Amino-7-Chloroquinolines [0.03%]
侧链对绿色4-烷氧基/氨基-7-氯喹啉的疏水性-抗菌性-毒性关联的影响
Gabriela F Fiss,Everton P Silva,Maria F S Madruga et al.
Gabriela F Fiss et al.
Background: More robust 4-substituted 7-chloroquinolines have been investigated for their diverse properties. However, there is still no systematic study that correlates the effects of the side chain at the 4-position of ...
Construction of an E3 Ubiquitin Ligase Gene Model to Predict the Prognosis of Idiopathic Pulmonary Fibrosis Patients Using Integrated Bioinformatics Analysis [0.03%]
基于整合生物信息学分析的特发性肺纤维化患者E3泛素连接酶基因模型的构建及预后价值评估研究
Junhui Liu,Longfei Zhu,Guirong Li et al.
Junhui Liu et al.
Introduction: Idiopathic pulmonary fibrosis (IPF) is a deadly lung disease and currently has limited treatment options. E3 ubiquitin ligases play a role in multiple diseases; however, there are few studies involving them ...
Diabetes and Skin Health: Insights into Autoimmunity, Metals, and AGE-Mediated Disorders [0.03%]
糖尿病与皮肤健康：自身免疫、金属和AGE介导紊乱的新视野
Geir Bjørklund,Monica Butnariu,Leonard Gurgas et al.
Geir Bjørklund et al.
Diabetes mellitus (DM) significantly impacts systemic and skin health, with advanced glycation end-products (AGEs), metal imbalances, and immune dysfunction emerging as central drivers of skin-related complications. Furthermore, dysregulati...
Exploring the Anti-Glioma Mechanisms of Oridonin: Network Pharmacology and Experimental Insights into EMT Pathways [0.03%]
穿心莲内酯抗胶质瘤作用机制研究：上皮间充质转化通路的网络药理学与实验洞察
Shiliang Chen,Yiran Fei,Xiaoli Jin et al.
Shiliang Chen et al.
Introduction: Gliomas are aggressive brain tumors with a poor prognosis and high recurrence. Oridonin, a traditional Chinese medicine, has shown potential in treating various cancers, but its role in glioma treatment, esp...
Imidazole-2-thione and Acylhydrazone Derivatives Targeting Carbonic Anhydrase-II: Synthesis, In-Vitro Evaluations, and MM-GBSA Calculation [0.03%]
咪唑并噻二唑及酰基腙衍生物靶向碳酸酐酶-II：合成、体外评价与MM-GBSA计算
Muhammad Ibrahim,Sobia Ahsan Halim,Majid Khan et al.
Muhammad Ibrahim et al.
Introduction: Several pathological conditions, including glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas, are commonly associated with carbonic anhydrase type II (CA-II). Additionally, CA-I...
Genetically Predicted Gastroesophageal Reflux Disease and Common Thyroid Disorders: A Two-sample Mendelian Randomization Study [0.03%]
基于基因的胃食管反流病与常见的甲状腺疾病：二样本孟德尔随机化研究
Hanxin Lv,Xinyu Yang,Ruting Zhang et al.
Hanxin Lv et al.
Introduction: The causality between thyroid disorders and Gastroesophageal Reflux Disease (GERD) remains to be deciphered. This two-sample Mendelian Randomization (MR) study was performed to elucidate the causal associati...
Boswellic acid derived molecules as SARS-CoV-2 spike protein inhibitors: A comprehensive virtual screening, triplicate molecular dynamic simulation and biochemical validation [0.03%]
基于没药酸的抗SARS-CoV-2刺突蛋白抑制剂的研究：全面虚拟筛选、重复分子动力学模拟及生化验证
Atta Ullah,Muhammad Waqas,Saeed Ullah et al.
Atta Ullah et al.
Background: Coronavirus disease (COVID-19) is a highly infective disease caused by SARS-CoV-2. The SARS-CoV-2 spike protein binds with the human ACE2 receptor to facilitate viral entry into the host cell; therefore, spike...