Effects of SGLT2 Inhibitors on Circulating Cyclophilin A Levels in Patients with Type 2 Diabetes [0.03%]
SGLT2抑制剂对2型糖尿病患者循环中环磷酸素A水平的影响
Furkan Kılıç,Fulya Odabaş,Abdulkadir İltaş et al.
Furkan Kılıç et al.
Objective: This study aimed to evaluate cyclophilin (CypA) levels in patients with diabetes mellitus (DM) before and after treatment. Metabolic variables, such as weight, blood pressure, and plasma glucose, were assessed ...
Recent Advances in Non-Viral Gene Delivery Systems for Hepatic Gene Therapy [0.03%]
用于肝脏基因治疗的非病毒基因传递系统最新进展
Roshanak Yadegarazari,Shima Lotfollahzadeh,Zahra Shabaninejad et al.
Roshanak Yadegarazari et al.
Gene therapy involves the modification of genetic material to correct or compensate for defective genes, thereby aiming to treat or prevent various diseases, including hepatic disorders. Recent advancements in non-viral nanocarrier systems,...
The Potential Antidiabetic Activity of Novel Nalidixic Acid-Based 1,2,4-Triazole Derivatives [0.03%]
一类新型萘啶羧酸基1,2,4-三氮唑衍生物的潜在抗糖尿病活性
Ibrahim Mhaidat,Bahaa Al-Trad,Sara Al-Rajabi et al.
Ibrahim Mhaidat et al.
Introduction: Diabetes mellitus affects the body's ability to regulate glucose and maintain insulin homeostasis. It has been linked to complications in the heart, kidneys, eyes, and other organs. Recent studies have repor...
Identification of Potential Biomarkers and Drugs for Papillary Thyroid Carcinoma Using Computational Analysis and Molecular Docking [0.03%]
基于计算分析和分子对接的乳头状甲状腺癌潜在生物标志物和药物识别研究
Tiantian Wang,Jiejun Tan,Zheng Bi et al.
Tiantian Wang et al.
Background: Papillary thyroid carcinoma (PTC), the most common thyroid malignancy, presents with multiple variants. This study aimed to identify potential biomarkers and therapeutic candidates for PTC through computationa...
Advances in Pharmacological Activities and Drug Delivery Systems of Licochalcone A [0.03%]
甘草黄酮素A的药理活性及药物递送系统的研究进展
Mingjie Ou,Shuwei Tang,Ziqing Deng et al.
Mingjie Ou et al.
Licochalcone A (Lic A) is a natural chalcone compound extracted from Glycyrrhiza inflata Batal, which exhibits a broad spectrum of pharmacological activities, including anti-inflammatory, antioxidant, anti-tumor, analgesic, hepatoprotective...
Using Disease Models for Mechanistic Studies: Special Focus on Gene Editing [0.03%]
利用疾病模型开展机制研究——基因编辑专题聚焦
Vasily Nikolaevich Sukhorukov,Alexander Nikolaevich Orekhov
Vasily Nikolaevich Sukhorukov
Antitumor and Immunoregulatory Effects of Curcumin Analog, (Z)-3-Hydroxy-1-(2-hydroxyphenyl)-3-phenyl prop-2-ene-1-one (DK1), on CT26-Tumor-Bearing BALB/c Mi [0.03%]
(Z)-3-羟基-1-(2-羟基苯基)-3-苯基丙-2-烯-1-酮(DK1)的抗肿瘤及免疫调节作用研究及其在荷CT26瘤BALB/c小鼠中的作用机制探讨
Yazmin Hussin,Nurul Fattin Che Rahim,Muhammad Nazirul Mubin Aziz et al.
Yazmin Hussin et al.
Introduction: Curcuma longa, commonly known as turmeric, contains curcumin, which is its main compound and has been reported to possess a wide variety of pharmacological activities, such as anti-carcinogenic, anti-malaria...
Rongxing Qin,Xiaojun Liang,Wei Xu et al.
Rongxing Qin et al.
Introduction: Ischemic stroke (IS) is a major cause of death and disability worldwide. The transcriptional mechanism of neutrophil extracellular trap-related genes (NRGs) and their diagnostic potential remain unknown. Thi...
Addressing Unmet Needs in Clostridium difficile Infection: Advances in Diagnosis, Treatment, and Prevention [0.03%]
艰难梭菌感染的未满足需求及诊疗进展
Ankit Sahoo,Janhvi Singh,Kainat Alam et al.
Ankit Sahoo et al.
Introduction: Clostridium difficile infection (CDI) is a serious global health concern characterized by toxin-induced colonic damage, ranging from diarrhea to life-threatening conditions. Despite improved diagnostics and ...
Computational Analysis and in vitro Verification Insights into Quercetin's Suppression of Neuroinflammation in BV-2 Microglia through NF-κB Pathway Inhibition [0.03%]
通过NF-κB途径抑制计算分析及体外验证 槲皮素对BV-2小胶质细胞神经炎症的抑制作用研究
Cheng-Yang Hsieh,Cheng-Hung Chuang,Marineil C Gomez et al.
Cheng-Yang Hsieh et al.
Introduction: Neuroinflammation, primarily mediated by activated microglia, is a significant contributor to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Quercetin (QCT), a dietary flavonoid, ha...