Optimization-Driven EEG-Based Seizure Detection in the Healthcare Internet of Things [0.03%]
基于优化的EEG脑电图在物联网远程健康检测中的 seizure 检测方法
Naresh Rana,Shruti Jain
Naresh Rana
Objective: This work proposes an automated system for the detection of epileptic seizures based on electroencephalogram (EEG) signals, integrating numerous metaheuristic optimization algorithms. This study aims to improve...
Studies on Hopf Cyclization in Cyclic-Aza and Oxa-Dieneyne Systems and Exploring their DNA Cleavage Properties [0.03%]
研究含氮氧杂二烯炔和环状氮杂二烯炔体系的霍夫曼cyclization及DNA断裂性质探索
Sayantan Mondal,Krishnendu Adhikary,Rajkumar Maiti
Sayantan Mondal
Introduction: This paper describes, for the first time, the synthesis of cyclic aza- and oxa-dieneynes through intramolecular aza-Wittig, Wittig, and lactonization reactions as key steps. The synthesized 9- and 10-membere...
Radionuclide Therapy of Prostate Cancer Using PSMA Ligands with a 4-Phenylbutyric Acid-Derived Albumin Binder: Recent Chemical and Clinical Advances [0.03%]
用于前列腺癌治疗的使用PSMA配体和4-苯基丁酸衍生白蛋白结合剂的放射核素治疗：近期化学及临床进展
Johanne Vanney,Jade Torchio,Lea Rubira et al.
Johanne Vanney et al.
Radioligand therapy (RLT) targeting the prostate-specific membrane antigen (PSMA) has become a key treatment modality for metastatic castration-resistant prostate cancer. However, the rapid clearance and suboptimal tumor uptake of current s...
Clinical Challenges in Echinococcosis Treatment and Frontiers in New Drug Development: Current Status and Future Outlook [0.03%]
棘球蚴病治疗临床挑战及新药研发前沿：现状与展望
Lin Wang,Zhengsheng Yan,Si Chen et al.
Lin Wang et al.
Echinococcosis, a zoonotic disease caused by larval Echinococcus tapeworms, manifests primarily as Cystic Echinococcosis (CE) and Alveolar Echinococcosis (AE). It poses a serious threat to the global livestock industry and public health. Ba...
Computational Analysis of Endothelial Cell-related Genes in Ovarian Cancer and Preliminary in vitro Validation of COL1A1 [0.03%]
卵巢癌血管内皮细胞相关基因的计算分析及COL1A1基因的初步体外验证
Zongtao Li,Jianmei Xia,Haixia Wang et al.
Zongtao Li et al.
Introduction: Endothelial cells play a crucial role in tumor invasion and metastasis. This study explored endothelial cell-targeted therapies for ovarian cancer (OC). ...
Bioinformatics-Guided Mechanistic Insights into Scutellaria Barbata Flavonoids Improving CREB Signaling-Related Cognitive Dysfunction through ERK-RSK-CREB Cascade Modulation [0.03%]
基于生物信息学的夏枯草黄酮改善CREB信号通路相关认知障碍的机制研究及 Networking 分析
Yan Chen,Chaojie Zhang,Xiaomin Yu et al.
Yan Chen et al.
Introduction: There is evidence showing that cognitive dysfunction is a typical characteristic in Alzheimer's Disease (AD) patients. CREB signaling-related neuronal dysfunction through ERK-RSK-CREB is a subtype of the pat...
Exploring the Therapeutic Potential of Mangiferin in Promoting Health Span and Stress Tolerance in C. elegans [0.03%]
杧果苷在促进秀丽隐杆线虫健康寿命和压力耐受性方面的治疗潜力探索
Saoban S Salimon,Elena I Marusich,Jude C Aneke et al.
Saoban S Salimon et al.
Background/objectives: Mangiferin is a natural compound with several known health benefits, including anti-diabetic, anti-cancer, anti-inflammatory, immunomodulatory, and antimicrobial effects, to mention a few. However, ...
Establishment and Validation of a Necroptosis-Related Long Noncoding RNA Prognostic Model for Non-Small Cell Lung Cancer [0.03%]
建立并验证用于非小细胞肺癌预后的坏死性凋亡相关长链非编码RNA模型及其机制研究
Zuojuan Yin,Yu Han,Peng Song
Zuojuan Yin
Introduction/objective: Non-small cell lung cancer (NSCLC) accounts for over 85% of lung cancers, and current immunotherapies benefit only a subset of patients. Necroptosis, a regulated form of necrotic cell death, has em...
Biosynthesis of Nimbin and the Metabolic Pathway: A Focus on its Antiviral Properties [0.03%]
Nimbin的生物合成及其代谢途径：重点关注其抗病毒特性
Gitishree DAS,Suman Nayak,Sushanto Gouda et al.
Gitishree DAS et al.
Introduction/objective: Nimbin, a triterpenoid limonoid from Azadirachta indica (Neem), is traditionally known for its diverse pharmacological potential, including antimicrobial and anti-inflammatory properties. However, ...
Identification of COX7B, GLRX5, and OR52H1 as Vascular Endothelial Injury-associated Biomarkers in Gestational Diabetes Mellitus [0.03%]
COX7B、GLRX5和OR52H1在妊娠糖尿病血管内皮损伤中的作用及其作为生物标志物的潜力识别研究
Yueping Wang,Weiwei Feng
Yueping Wang
Introduction: This study aimed to screen and validate such biomarkers to clarify the role of vascular endothelial injury (VEI) in the pathogenesis of gestational diabetes mellitus (GDM) and provide clues for future diagno...