Recent Advances on PKM2 Inhibitors and Activators in Cancer Applications [0.03%]
PKM2抑制剂和活化剂在癌症治疗中的最新研究进展
Peng Chen,Liang Lou,Bigyan Sharma et al.
Peng Chen et al.
Metabolic reprogramming of cells, from the normal mode of glucose metabolism named glycolysis, is a pivotal characteristic of impending cancerous cells. Pyruvate kinase M2 (PKM2), an important enzyme that catalyzes the final rate-limiting s...
Small Molecule Inhibitors of Human Papillomavirus: A Review of Research from 1997 to 2021 [0.03%]
1997至2021年人乳头瘤病毒的小分子抑制剂研究进展综述
Caitlin L Duncan,Hendra Gunosewoyo,Mauro Mocerino et al.
Caitlin L Duncan et al.
Human papillomavirus (HPV) infections are the cause of warts, lesions and cancer, with different types of HPV causing different symptoms. HPV infections are the primary cause of cervical cancer. There are over 220 different types of HPV, an...
CircRNAs as a novel class of potential diagnostic biomarkers in bipolar disorders [0.03%]
圆环状RNA作为双相障碍中一类新的潜在诊断生物标志物
Reza Asemi,Amrollah Ebrahimi,Michael R Hamblin et al.
Reza Asemi et al.
Bipolar disorder (BD) is a severe mood disorder with uncertain causes and debilitating signs and symptoms. Gene expression is crucial to the pathophysiology of BD and could be influenced by genetic or epigenetic factors, by either direct mo...
1,3,4-Oxadiazole: An Emerging Scaffold to Inhibit the Thymidine Phosphorylase as an Anticancer Agent [0.03%]
1,3,4-氧硫杂环戊烯作为一种抗肿瘤药物抑制胸苷磷酸化酶的新兴骨架
Anjali Murmu,Purusottam Banjare,Balaji Wamanrao Matore et al.
Anjali Murmu et al.
Thymidine phosphorylase (TP), also referred to as "platelet-derived endothelial cell growth factor" is crucial to the pyrimidine salvage pathway. TP reversibly transforms thymidine into thymine and 2-deoxy-D-ribose-1-phosphate (dRib-1-P), w...
The Beneficial Effects of Curcumin on Lipids: Possible Effects on Dyslipidemia-Induced Cardiovascular Complications [0.03%]
姜黄素对血脂的有益作用及其对血脂异常引起的心血管并发症的影响研究
Habib Yaribeygi,Mina Maleki,Alexandra E Butler et al.
Habib Yaribeygi et al.
Dyslipidemia and altered lipid metabolism are closely involved in the pathogenesis and clinical manifestation of many metabolic and non-metabolic diseases. Therefore, mitigation of pharmacological and nutritional factors together with lifes...
Linoleic and arachidonic fatty acids and their potential relationship with inflammation, pregnancy, and fetal development [0.03%]
亚油酸和花生四烯酸及其与炎症、怀孕和胎儿发育的潜在关系
Macarena Ortiz,Daniela Álvarez,Yasna Muñoz et al.
Macarena Ortiz et al.
Background: A healthy maternal diet must consider an appropriate supply of long-chain polyunsaturated fatty acids (LCPUFAs) precursors to ensure adequate growth and development of the fetus. In this regard, n-6 PUFAs, pre...
Fluvastatin: a choice for COVID-19 associated mucormycosis management [0.03%]
氟伐他汀：治疗COVID-19相关毛霉病的选择之一
Alireza Tavakkoli,Thomas P Johnston,Amirhossein Sahebkar
Alireza Tavakkoli
SARS-CoV-2 invades the respiratory tract epithelium and can result in systemic inflammation prior to an infection caused by either bacteria or fungus. COVID-19-associated mucormycosis (CAM) is a serious condition that can occur during the t...
The efficacy of dietary approaches to stop hypertension (DASH) diet on lipid profile: A systematic review and meta-analysis of clinical controlled trials [0.03%]
Dietary Approaches to Stop Hypertension(DASH)饮食对血脂谱影响的系统评价和meta分析
Amirhossein Sahebkar,Zahra Heidari,Zahra Kiani et al.
Amirhossein Sahebkar et al.
Background: Dyslipidemia is considered a causal risk factor for coronary heart disease and stroke. Plant-based diets such as dietary approaches to stop hypertension (DASH) have beneficial effects on cardiovascular health....
Agnieszka Skibska,Renata Perlikowska
Agnieszka Skibska
In many circumstances, some crucial elements of the neuronal defense system fail, slowly leading to neurodegenerative diseases. Activating this natural process by administering exogenous agents to counteract unfavourable changes seems promi...