Diminazene Aceturate (DIZE) Ameliorates Hypertension and Induces Anxiolytic- and Antidepressant-Like Effects in TGR(Mren2)27 [0.03%]
癸酸去嗪胺(DIZE)可改善TGR(Mren2)27的高血压并具有抗焦虑和抗抑郁作用
Laura A Costa,Flávio A G Mourão,Natalia Alenina et al.
Laura A Costa et al.
Introduction: Diminazene aceturate (DIZE) was described as an angiotensin-converting enzyme 2 (ACE2) activator. ACE2/Angiotensin-(1-7)/Mas receptor axis presents protective actions on cardiovascular diseases and plays an ...
A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders [0.03%]
人类素肽及其类似物在代谢障碍治疗中调节自噬途径的潜在作用综述
Hira Moin,Rizwan Ashraf,Batool Butt et al.
Hira Moin et al.
Autophagy is a self-eating cellular process in which the cell breaks down worn-out organelles, damaged/defective proteins, and toxins. Impaired autophagy is a significant factor in the development of various metabolic disorders, along with ...
Inconsistent Protein Stability Despite Pre-HECT Domain Helix: Unveiling Variability in HECT Ligases [0.03%]
尽管存在前HECT结构域螺旋，蛋白质稳定性仍不一致：揭示HECT连接酶的可变性
Çağdaş Dağ,Cansu Deniz Tozkoparan Ceylan,Cemre Sare Cansız
Çağdaş Dağ
Introduction: Ubiquitin and ubiquitin-like systems play crucial roles across a wide range of organisms, from simple to complex. Among the three enzyme-mediated post-translational modification (PTM) steps, the ligation ste...
miR-584-5p Regulates MSMO1 to Modulate the AKT/PI3K Pathway and Inhibit Breast Cancer Progression [0.03%]
miR-584-5p通过调节MSMO1调控AKT/PI3K通路并抑制乳腺癌进程
Xin Li,Jie Liu,Lili He et al.
Xin Li et al.
Introduction: Endogenous microRNAs (miRNAs) are critical regulators of tumor progression, making their role in breast cancer an important area of investigation. ...
Anti-Cancer Bioactive Peptide Induces Apoptosis in Gastric Cancer Cells through TP53 Signaling Cascade [0.03%]
抗癌症生物活性肽通过TP53信号级联诱导胃癌细胞凋亡
Qimuge Suyila,Xian Li,Xiulan Su
Qimuge Suyila
Introduction: Gastric cancer has emerged as one of the major diseases threatening human health. Our previous studies indicated that the anti-cancer bioactive peptide (ACBP) inhibits the initiation and progression of gastr...
iRGD Tumor Penetrating Peptide-Modified NK Cells Exhibit Enhanced Tumor Immune Infiltration Ability and Anti-Tumor Efficacy [0.03%]
iRGD肿瘤穿膜肽修饰的NK细胞表现出增强的肿瘤免疫浸润能力和抗肿瘤效应
Ge Song,Xueyong Qi,Yi Zhao
Ge Song
Background: Natural killer (NK) cells, as part of the group I innate lymphocytes (ILCs) are essential for tumor immune surveillance. NK cells can recognize and eliminate target cells without the need for prior sensitizati...
Comparative In Silico and In Vitro Studies of Novel Zinc/Tin Metal Coordinates Bearing BRCA-1 Mimetics on Wtp53 and Mtp53 Proteins [0.03%]
新型含BRCA-1模拟物的锌/锡金属配位对Wtp53和Mtp53蛋白的计算与体外比较研究
Preeya Negi,Akey Krishna Swaroop,Anuj Kumar Singh et al.
Preeya Negi et al.
Purpose: This study compares the activity of BRCA-1 mimetics on WTp53 (wild-type p53 protein) and MTp53 (mutated-type p53 protein) proteins, examining the impact of TP53 mutations in breast cancer. p53 activators can be a...
Molecular Interactions of the Antimicrobial Peptide Tritrpticin with Mixed Nanoaggregates: A Fluorescence Spectroscopy Study [0.03%]
抗菌肽Tritrpticin与混合纳米聚集体相互作用的荧光光谱研究
Kaio César Antunes Rocha,Maria Carolina Oliveira de Arruda Brasil,Eduardo Maffud Cilli et al.
Kaio César Antunes Rocha et al.
Introduction: Tritrpticin (TRP3) is a peptide belonging to the cathelicidin family and has a broad spectrum of antimicrobial activity. However, this class of biomolecules can be easily degraded in the body, making it nece...
ZNF165: A Pan-Cancer Biomarker with Prognostic and Therapeutic Potential [0.03%]
ZNF165：一个具有预后和治疗潜力的泛癌症生物标志物
Guizhen Lyu,Dongbing Li
Guizhen Lyu
Background: The role of ZNF165 in only a few tumors has been reported. ZNF165 plays an important role in liver cancer, gastric cancer, and breast cancer, especially in regulating the immune microenvironment, promoting tum...
MARVELD1 Promotes the Invasiveness in Pancreatic Adenocarcinoma through the Activation of Epithelial-to-Mesenchymal Transition [0.03%]
MARVELD1通过激活上皮间质转化促进胰腺导管腺癌侵袭性
Xianwei Luo,Zhenming Gao
Xianwei Luo
Background: MARVEL domain-containing 1 (MARVELD1) has been implicated in the progression of several cancers, but its role in pancreatic adenocarcinoma (PAAD) remains poorly understood. ...