Enhanced Cell Surface Expression Enables Purification and Structural Characterization of Human GPRC6A [0.03%]
改进的细胞表面表达使人类GPRC6A的纯化及其结构表征成为可能
Yifeng Zhong,Tianjin Liu,Yuequan Shen et al.
Yifeng Zhong et al.
Introduction: The G-protein-coupled receptor class C group 6 member A (GPRC6A) is a member of the class C G-Protein-Coupled Receptor (GPCR) family and functions as a nutrient and hormone sensor involved in metabolic and e...
Kai Hilpert
Kai Hilpert
The human gut microbiome is now recognised as a major determinant of health, with roles extending beyond digestion to influence neurodegeneration, metabolism, immunity, and pharmacological responses. Clinical studies link microbial imbalanc...
Targeting Autoimmunity in Myasthenia Gravis: From Conventional to Novel Therapeutic Approaches [0.03%]
重症肌无力的自身免疫治疗：从传统到新型疗法
Vishal Chanalia,Smita Narwal,Gurvirender Singh et al.
Vishal Chanalia et al.
Myasthenia Gravis is a chronic autoimmune neuromuscular disorder characterized by fluctuating skeletal muscle weakness, most commonly involving ocular, bulbar, respiratory, and limb muscles. This weakness stems from autoantibodies, predomin...
Advances in Polymeric Drug Delivery Systems: From Biodegradability to Nanocarrier Technologies [0.03%]
聚合物药物传递系统的发展：从中分子可降解性到纳米载体技术
Abhay Thakur,Rohit Sharma,Shriyanshu Thakur et al.
Abhay Thakur et al.
Research studies indicate that biodegradable polymers play a crucial role in effective drug delivery, helping to manage drug release and decreasing potential toxic reactions. It thoroughly reviews different types of biodegradable polymers, ...
Dimerization of SARS-CoV-2 3CLpro and the Role of the A7G/V125G Zipper Interface [0.03%]
SARS-CoV-2 3CLpro二聚作用及A7G/V125G拉链界面的作用
Rafida Razali,Cahyo Budiman,Vijay Kumar
Rafida Razali
Introduction/objectives: The 3-chymotrypsin-like protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for viral replication and is catalytically active only in its dimeric form. E...
Bioactive Peptides: Production Strategies, Biological Activities, and Emerging Therapeutic Applications [0.03%]
生物活性肽的生产策略、生物学活性及新兴治疗应用
Jasvinder Saini,Smita Narwal,Jagdeep Singh et al.
Jasvinder Saini et al.
Bioactive peptides, short chains of amino acids derived from natural sources like animals, plants, and marine organisms, are increasingly being explored for their roles in nutrition, functional foods, and therapeutic applications. These pep...
Recent Developments, Challenges in Bitter Gourd Protein and Peptide Extraction Strategies, Techno-Functional Properties, Bioaccessibility, and Commercial Applications [0.03%]
近年来关于苦瓜的蛋白和肽提取策略、技术功能属性、生物可利用度及商业化应用等方面的进展与挑战
Tawseefa Jan,Rajvinder Kour,Seerat Sharma et al.
Tawseefa Jan et al.
Bitter gourd (Momordica charantia L.) has turned out to be a significant source of proteins and bioactive peptides, which have prospects of finding application in functional foods and nutraceuticals. It contains a high level of proteins and...
Recent Development of the Probes for Fluorescence Spectroscopy, Mass Spectrometry and Electron Microscopy in Cancer Diagnosis [0.03%]
癌症诊断中用于荧光光谱、质谱和电子显微镜的探针研究进展
Shikha Baghel Chauhan,Saksham Sharma,Chirag Jain et al.
Shikha Baghel Chauhan et al.
Among the different types of cancer, brain cancer is one of the most dangerous and fatal. Therefore, the emphasis on effective and accurate diagnosis and treatment methods is highly significant. The combination of fluorescent probes and mas...
TRIM44 as a Multifunctional Regulator in Cancer and Non-Cancer Diseases: From Oncogenic Driver to Immune and Stress Response Modulator [0.03%]
TRIM44在癌症和非癌症疾病中的多功能调节作用：从致癌驱动因子到免疫和应激反应调节剂
Guive Sharifi,Tohid Emami Meybodi,Fatemeh Jayervand et al.
Guive Sharifi et al.
Tripartite motif-containing protein 44 (TRIM44), a unique member of the TRIM family that lacks the canonical RING domain, has recently attracted significant attention for its broad oncogenic potential across diverse malignancies. Accumulati...
Peptide Extract from Apricot Kernels Mitigates Damage in Human Aortic Endothelial Cells Induced by Polystyrene Microplastics through the Inhibition of the NLRP3 Signaling Pathway [0.03%]
微塑料通过抑制NLRP3信号通路损伤人主动脉内皮细胞的损害防护作用机制研究——樱桃核多肽提取物的作用与机理探究
Minghui Tian,Yemeng Zhang,Xiaolei Liu et al.
Minghui Tian et al.
Introduction: Polystyrene microplastics (PS-MPs) contribute to cardiovascular pathologies by inducing vascular endothelial injury through oxidative stress and inflammation. This study aimed to investigate the protective r...