Irisin Mitigates Myocardial Hypoxia/Reoxygenation Injury by Preserving Mitochondrial Redox Homeostasis via the UCP2-SOD2 Axis [0.03%]
irisin通过UCP2-SOD2轴维持线粒体氧化还原稳态来减轻心肌缺氧复氧损伤
Yizhen Xu,Huanqing Liu,Shuang Liu et al.
Yizhen Xu et al.
Introduction: Mitochondrial redox homeostasis is of utmost significance in myocardial ischemia-reperfusion (I/R) injury. Irisin, a myokine, has drawn extensive attention in research regarding the protection against cardio...
Immunity in Harmony: Utilizing Overlapping Epitopes for Tuberculosis and COVID-19 Protection [0.03%]
和谐免疫：利用结核病和新型冠状病毒肺炎的重叠表位来预防疾病
Kritika Pasricha,Shivank Prajapati,Taruna Lamba et al.
Kritika Pasricha et al.
Introduction: The BCG vaccine, widely administered against tuberculosis, has also been linked to reduced incidence of bacterial and viral infections, particularly those affecting the respiratory tract. Its antigens enhanc...
MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway [0.03%]
MOTS-c通过MAPK信号途径对抗乙酰氨基酚致肝损伤
Nan Li,Yimin Xu,Qixin Chen et al.
Nan Li et al.
Objective: Acetaminophen (APAP)-induced liver injury (AILI) is a leading cause of acute liver failure worldwide, but effective therapeutic strategies are still lacking. MOTS-c, a mitochondrial-derived peptide, has demonst...
Proteome-Wide Acetylome Profiling Suggests Extensive Aspirin-Driven Remodeling of Networks Relevant to THP-1 Macrophage Differentiation [0.03%]
基于蛋白质组的乙酰化修饰组学分析表明阿司匹林可驱动与THP-1巨噬细胞分化相关的多个网络重构
Zi-Hui Ma,Yuan-Qing Pan,Pir Tariq Shah et al.
Zi-Hui Ma et al.
Introduction: Acetylsalicylic Acid (aspirin or ASA) is known to exhibit immunomodulatory effects not only through Cyclooxygenase (COX) inhibition but also through direct protein acetylation. However, its impact on innate ...
Structural Insights into Ligand-Induced Conformational Changes in Adenine Phosphoribosyl Transferase from Fusobacterium nucleatum [0.03%]
解螺旋体核体菌腺嘌昤磷酸核糖转移酶的配体诱导构象变化的结构洞察
Bogeun Kim,Jisub Hwang,Hackwon Do et al.
Bogeun Kim et al.
Background: Adenine phosphoribosyltransferase (APRT) is an enzyme that facilitates adenosine monophosphate (AMP) biosynthesis by transferring a phosphoribosyl group to adenine using phosphoribosyl pyrophosphate as a donor...
Optimized Strategy for Expression, On-Column Refolding, and Purification of NEDD8 Protein [0.03%]
NEDD8蛋白的高效表达、柱上复性及纯化策略优化研究
Shalu Yadav,Neeraj Kumar Fauzdar,Yashwant Kumar Yadav et al.
Shalu Yadav et al.
Introduction: Ubiquitin and the Ubls family are known for their high solubility and excellent expression profiles in recombinant systems. In contrast, Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NED...
Prolyl 4-Hydroxylase Beta Peptide Promotes Invasion, Migration, and Epithelial-Mesenchymal Transition through Activation of the Claudin-1/ AMPK/TGF-β1 Pathway in Bladder Cancer Cells [0.03%]
脯氨酰羟化酶β肽通过激活闭合蛋白-1/AMPK/TGF-β1通路促进膀胱癌细胞侵袭、迁移及上皮间质转化
Mingning Qiu,Shuai Zhang,Jinglan Liang et al.
Mingning Qiu et al.
Introduction: Prolyl 4-hydroxylase beta peptide (P4HB) is a novel diagnostic and prognostic marker associated with cancer progression and clinical outcomes, and it is upregulated in multiple types of cancer cells. However...
mRNA-Based Cancer Vaccines: A Review of the Current Scenario and Future Prospects [0.03%]
基于mRNA的癌症疫苗：当前情况与未来前景综述
Sanchari Bhattacharya,Nilufa Easmin,Atanu Panja et al.
Sanchari Bhattacharya et al.
Messenger RNA (mRNA) has gained increasing attention as a valuable tool to cure various human diseases, particularly malignant tumors. Such growing interest has been triggered largely by the phenomenal clinical success of mRNA vaccines deve...
Margatoxin Peptide: Preparation and the Potential Use for Biological Applications in Cancer and Neurological Disorders [0.03%]
斑蝥素肽：制备及其在癌症和神经性疾病生物应用中的潜在用途
Faride Ranjbari,Masoomeh Dadkhah,Zahra Pirdel et al.
Faride Ranjbari et al.
Scorpion venom compounds are known to contain nucleotides, polypeptides, mucoproteins, lipids, biogenic amines, and other unidentified macromolecules. Several peptides in scorpion fluids have demonstrated a wide range of biological activiti...