Enhancing Tissue Factor Production: The Role of N-Glycosylation and ERAD Pathway Modulation [0.03%]
增强组织因子生成：N-糖基化和内质网关联降解通路调节的作用
Yi-Shi Liu,Yue Dou,Xiaoman Zhou et al.
Yi-Shi Liu et al.
Background: Tissue Factor (TF) is a crucial transmembrane glycoprotein that triggers blood coagulation upon vascular or tissue injury by binding to plasma factors VII and VIIa. In recent years, the demand for TF has rapid...
Design, Expression, and Purification of a Fusion Enzyme Containing Terminal Deoxynucleotidyl Transferase from B. bovis and DNA-Binding Proteins from E. coli [0.03%]
含有巴贝斯虫末端脱氧核苷酸转移酶及大肠杆菌DNA结合蛋白的融合酶的设计、表达和纯化
Antos Sachanka,Veronika Shchur,Yaraslau Dzichenka et al.
Antos Sachanka et al.
Background: Gene fusion techniques have yielded promising results in the fusion of thermostable polymerases (Taq and Pfu) with single-stranded and double-stranded DNA-binding proteins. Constructing a terminal deoxynucleot...
Molecular Cloning and Expression of Cryptocyanin Gene Isolated from an Indian Variety of Scylla olivacea [0.03%]
来源于印度橄榄型沼虾的Cryptocyanin基因的克隆及表达
Simran Mann,Chittibabu Shanthi,Manu Asthana
Simran Mann
Background: Molting and reproduction play vital roles in the life cycle of brachyuran crabs, and these two processes are closely interconnected. A key player in the molting cycle is cryptocyanin, which is similar to hemoc...
Cell-Free Expression of HPV16 Minor Capsid Protein L2 and Its Interaction with S100A10 [0.03%]
人乳头瘤病毒16型次要衣壳蛋白L2的无细胞表达及其与S100A10相互作用研究
Wenqi Jiang,Lian Wu,Xiangchun Shen et al.
Wenqi Jiang et al.
Background: Human papillomavirus type 16 (HPV16) is implicated in various malignancies. The virus enters host cells through endocytosis, during which the minor capsid protein L2 interacts with the S100A10 subunit of the a...
Virtual Screening of Phytoconstituents in Indian Spices Based on their Inhibitory Potential against SARS-CoV-2 [0.03%]
基于对SARS-CoV-2抑制潜力的印度香料植物成分虚拟筛选
Vaishali Singh,Aliza Rabbani,Veda P Pandey
Vaishali Singh
Background: COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly pathogenic human coronavirus (CoV). For the treatment of COVID-19, various drugs, ayurvedic formulations, used for o...
Cleverson Diniz Teixeira de Freitas,Jefferson Soares de Oliveira
Cleverson Diniz Teixeira de Freitas
Peptidases play crucial roles in numerous physiological processes within living organisms. Therefore, they have been employed in various pharmaceutical applications. Plant peptidases have attracted considerable attention in various areas du...
Development of a Peptide-Based Multiepitope Vaccine from the SARS-CoV-2 Spike Protein for Targeted Immune Response Against COVID-19 [0.03%]
基于SARS-CoV-2刺突蛋白的多抗原肽疫苗的开发，用于针对COVID-19的靶向免疫反应
Thales Alves Campelo,Pedro Filho Noronha Souza,Daiane Maria Silva Brito et al.
Thales Alves Campelo et al.
Background: Since the Coronavirus Disease (COVID-19) became a pandemic in late 2019, vaccination remains the primary approach to combating the virus. Nevertheless, the emergence of new variants poses challenges to vaccine...
Expression, Purification, and Preliminary Characterization of Putative Protein Tyrosine Phosphatase Oca1 [0.03%]
Oca1假定的蛋白质酪氨酸磷酸酶的表达、纯化及初步性质研究
Madhu Patel,Ashutosh Kumar,Kam Y J Zhang et al.
Madhu Patel et al.
Introduction/objective: Protein phosphatases act as counterparts to protein kinases and are considered crucial for the homeostatic balance of cell signalling. In contrast to kinases, which can be categorized according to ...
Unveiling the Potential Role of Hesperetin and Emodin as a Combination Therapy to Inhibit the Pancreatic Cancer Progression against the C-Met Gene [0.03%]
揭示橙皮素和大黄素作为联合疗法抑制胰腺癌进展的潜在作用机制针对C-Met基因
Rangaraj Kaviyaprabha,Thandaserry Vasudevan Miji,Puthupparambil Shaji Sreelakshmi et al.
Rangaraj Kaviyaprabha et al.
Background: Pancreatic adenocarcinoma (PAAD) is one of the most prevalent cancers, and it has high death rates. Only 10% of PAAD patients can survive until 5 years. Hence, the improvement of survival rate of the patients ...
Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential [0.03%]
植物来源的环肽在免疫调节及其治疗潜力中的作用
Reema Mishra,Preeti Agarwal,Anshita Sharma et al.
Reema Mishra et al.
The incidences of immune-related disorders have drastically increased in recent years across the world population. Treatment and management of these diseases, especially autoimmune disorders, are complex and challenging. Available synthetic...