A Preliminary Study on the Antibacterial Activity of the Secretion of the Levantine Water Frog, Pelophylax bedriagae (Camerano, 1882) (Anura:Ranidae) [0.03%]
波斯南部水蛙(Pelophylax sahidicu)抗菌活性初步研究
Nazlı Atçi,Ebru Tanriverdio,Dinçer Ayaz
Nazlı Atçi
Introduction: The skin of amphibians performs some vital roles, such as camouflage, ion and water transport, and gas exchange. Additionally, it plays a significant role in the immune system by preventing pathogen invasion...
Evaluation of the Cardioprotective Potential of Syzygium aromaticum in High-Glucose and Trimethylamine-N-Oxide-Induced In-Vitro Diabetic Cardiomyopathy [0.03%]
评估Syzygium aromaticum在高糖和三甲胺-N-氧化物诱导的糖尿病心肌病中的心脏保护潜力
Shivani Singhal,Jatin Gupta,Prem Prakash Kushwaha et al.
Shivani Singhal et al.
Introduction: Diabetic hyperglycemia is often associated with elevated levels of trimethylamine-N-oxide (TMAO), a gut microbiota-derived metabolite that was recently identified as a risk factor for cardiovascular diseases...
Zahra Moghaddasi,Azam Bolhassani,Elnaz Agi
Zahra Moghaddasi
Leukemia is one of the most prevalent malignancies worldwide that causes the unusual evolution of hematopoietic stem cells. The type of leukemia determines the optimal treatment plan and the patient's survival. However, finding safer and mo...
Mevalonate Metabolic Reprogramming Drives Cisplatin Resistance in Bladder Cancer: Mechanisms and Therapeutic Targeting [0.03%]
梅考岭酸代谢重组驱动膀胱癌顺铂耐药：机制及治疗靶向策略
Qixiang Fang,Chengyu You,Xi Xiao et al.
Qixiang Fang et al.
Introduction: Dysregulation of mevalonate metabolism is a hallmark of tumorigenesis and therapy resistance across malignancies, though its role in bladder cancer remains unclear. This study aimed to elucidate its impact o...
Essential Role of Non-Conserved α4-His178 in Stabilizing the α4-α5 Hairpin and Biotoxicity of the Cry4Aa Mosquitocidal Protein [0.03%]
保守性较差的α4-His178残基在蚊幼虫毒蛋白Cry4Aa的α4-α5发卡结构稳定及生物毒性中的重要作用
Chompounoot Imtong,Walairat Bourchookarn,Apichai Bourchookarn et al.
Chompounoot Imtong et al.
Background: Bacillus thuringiensis Cry toxins are well known for their insecticidal properties, primarily through the formation of ion-leakage pores via α4-α5 hairpins. His178 in helix 4 of the Cry4Aa mosquito-active to...
Sampriti Paul,Prashant Tiwari,Sonal Dubey
Sampriti Paul
Introduction: Neurodegenerative disorders such as Alzheimer's, Parkinson's, and ALS are characterized by progressive neuronal dysfunction with limited therapeutic options. Recent advances in molecular biology and drug dev...
Evaluation of Anti-cancer Potential of Abelmoschus esculentus (Okra) [0.03%]
评估 Abelmoschus esculentus（秋葵）的抗癌潜力
Maanniya Gakhar,Lovepreet Singh,Sanjeev Routh et al.
Maanniya Gakhar et al.
Introduction: Abelmoschus esculentus (okra) from the Malvaceae family is widely used in culinary applications and is reported to have many potential therapeutic effects attributed to the compounds isolated from it. In thi...
F18 Promiscuous Epitope of Acr1 Protein of Mycobacterium tuberculosis Induces the Secretion of IL-10 and Tregs But Not IL-6 [0.03%]
结核分枝杆菌Acr1蛋白的F18多表位诱导产生IL-10和Tregs但不产生IL-6
Taruna Lamba,Shivank Prajapati,Arnab Chowdhury et al.
Taruna Lamba et al.
Introduction: Mycobacterium tuberculosis (Mtb) is a Gram-positive bacterium that causes tuberculosis (TB). It remains viable for extended periods within host macrophages by entering a dormant state. Alpha crystallin 1 (Ac...
Kalyani R Thombre,Krishna R Gupta,Tejaswini P Masne et al.
Kalyani R Thombre et al.
Recombinant proteins, which are produced using recombinant DNA technology, have transformed the domains of biotechnology and biomedicine by allowing the production of proteins that are often expensive or difficult to obtain from natural sou...
Unlocking the Keratinolytic Potential of Brevibacillusagri Derived Keratinase: A Molecular Characterization Study [0.03%]
源自Brevibacillus agri的角蛋白酶降解角蛋白潜能的分子特性研究
Hira Batool,Beenish Maqsood,Hira Muzzamal et al.
Hira Batool et al.
Background: Keratinases have an established role in degrading highly stable and insoluble fibers of keratin proteins, which are otherwise difficult to be hydrolyzed by conventional proteases. Keratinases find promising ap...