Evaluation of the Anti-Liver Cancer Activity of Protein Fractions Isolated from Adenium obesum Leaf Extract [0.03%]
评估腺叶提取物的抗肝癌活性蛋白质片段的效果
Ashkan Hajinourmohammadi,Jamil Zargan,Hanieh Jafary et al.
Ashkan Hajinourmohammadi et al.
Introduction: Liver cancer is the third leading cause of cancer-related death. Plantderived therapeutics have played a significant role in preventing and treating many diseases, including cancers. The present study invest...
Aloperine Protects Against Cisplatin-Induced Injury in Kidney Cells Via Modulating PI3K/AKT/Nfκb-Mediated NLRP3 Inflammasome [0.03%]
Aloperine通过调节PI3K/AKT/NFκB介导的NLRP3炎性小体保护顺铂诱导的肾细胞损伤
Mingning Qiu,Shuai Zhang,Jinglan Liang et al.
Mingning Qiu et al.
Background: Aloperine (ALO) is a vital alkaloid present in the traditional Chinese herb Sophora alopecuroides, which has demonstrated effective anti-inflammatory activity. However, the effects and the mechanism of action ...
Shepherin II Gene Synthesis and Peptide Characterization: E. coli Expression, Purification, and Antiviral Activity [0.03%]
II型牧草素基因合成及肽段特性分析：克隆表达、纯化及其抗病毒活性研究
Azza Abd Elfattah,Safia Samir,Hend Okasha et al.
Azza Abd Elfattah et al.
Introduction: The shepherin II peptide is characterized by a histidine/glycine-rich sequence. This study aimed to design, express recombinantly, and evaluate the antiviral activity of shepherin II against hepatitis A viru...
Role of TPD52 in Endometrial Cancer: Impact on EMT and the PI3K/AKT and ERK/MAPK Signaling [0.03%]
TPD52在子宫内膜癌中的作用：对EMT及PI3K/AKT和ERK/MAPK信号通路的影响
Lu Miao,Buze Chen,Linlin Li et al.
Lu Miao et al.
Introduction: Endometrial carcinoma (EC) incidence and mortality continue to rise, and reliable therapeutic targets remain scarce. We aimed to define the oncogenic role and mechanism of tumor protein D52 (TPD52) in EC, fo...
Customizing Proteins: Reassigning Functionality of Proteins via Incorporation of Unnatural Amino Acids [0.03%]
定制蛋白质：通过引入非天然氨基酸重新分配蛋白质的功能性
Maharsh Jayawant,Nagarajan Kayalvizhi,Muthukalingan Krishnan et al.
Maharsh Jayawant et al.
The natural horizon of the genetic code has expanded to incorporate amino acids, such as selenocysteine and pyrrolysine. Researchers have incorporated unnatural amino acids (UAAs) into target proteins, demonstrating increased protein functi...
Role of 5-Hydroxydecanoate in the Neuroprotective Activity of Diosmetin Against Rotenone-Induced Dopaminergic Toxicity in Rats [0.03%]
黄酮类化合物山柰酚通过5-羟基癸酸发挥神经保护作用及其机制研究
Krishna Kumar Varshney,Jeetendra Kumar Gupta,Rajnish Srivastava
Krishna Kumar Varshney
Introduction: The present study aims to compare the monotherapy of diosmetin and 5- hydroxydecanoate (5-HD) against the therapeutic effect of their combination therapy in the unilaterally injected rotenone-induced neuroto...
Xander Calicdan,Oriana S Fisher,Byung Hak Ha et al.
Xander Calicdan et al.
Introduction: Numerous X-ray crystal structures of the c-Src SH3 domain have provided a large sampling of atomic-level information for this important signaling domain. Multiple crystal forms have been reported, with varia...
Improving Acid-Base Pair Concentration in Wash/Elution Buffer Eliminates Elution Peak-Shouldering in Cation Exchange Chromatography [0.03%]
通过改进酸碱对浓度消除阳离子交换色谱中的洗脱峰肩部现象
Fei Huang,Na Liu
Fei Huang
Introduction: Peak-shouldering elution behavior was a common and unexpected result in bind-and-elute mode Cation Exchange Chromatography (CEX), which may be due to the pH transition during the elution step and the aggrega...
Cloning, Expression, Purification, and Characterization of Superoxide Dismutase from the Soil Metagenome [0.03%]
土壤宏基因组来源超氧化物歧化酶的克隆、表达、纯化及性质鉴定
Nancy,Sudarshan Singh Lakhawat,Rajender Kumar et al.
Nancy et al.
Introduction: Superoxide Dismutases (SODs) are enzymes that catalyze the conversion of toxic free radicals generated during stress conditions into nontoxic forms. Thus, the enzyme superoxide dismutase contributes to the a...
PLEKHG7 Expression: A Biomarker for Prognosis and Targeted Therapy in Diffuse Large B-cell Lymphoma [0.03%]
PLEKHG7表达：在弥漫性大B细胞淋巴瘤中预后和靶向治疗的生物标志物
Guizhen Lyu,Dongbing Li
Guizhen Lyu
Introduction: Pleckstrin homology and RhoGEF domain-containing G7 (PLEKHG7) is a largely uncharacterized gene whose role in diffuse large B-cell lymphoma (DLBCL) remains unexplored. Thus, we aimed to profile PLEKHG7 expre...