Meng Han,Congmin Wang,Ping Liu et al.
Meng Han et al.
Accumulating evidence is dramatically increasing the access to the facts that the gut microbiota plays a pivotal role in host metabolism and health, which revealed the possibility of a plethora of associations between gut bacteria and human...
From Disorder to Mis-Order: Structural Aspects of Pathogenic Oligomerization in Conformational Diseases [0.03%]
从紊乱到错置：构象病原性寡聚化的结构特征
Chin Pang Benny Yiu,Yu Wai Chen
Chin Pang Benny Yiu
Proteins implicated in neurological conformational diseases contain substantial amounts of "intrinsic disorder". These native monomeric functional states may transit into some oligomeric states that have high β-sheet contents and seed the ...
Plasmodium falciparum Heat Shock Protein 70 Lacks Immune Modulatory Activity [0.03%]
恶性疟原虫热休克蛋白70缺乏免疫调节活性
Ofentse Jacob Pooe,Gabriele Köllisch,Holger Heine et al.
Ofentse Jacob Pooe et al.
Background: Heat shock protein 70 (Hsp70) family are conserved molecules that constitute a major part of the cell's protein folding machinery. The role of Hsp70s of parasitic origin in host cell immune modulation has rema...
Marta Kotorman,Phanindra B Kasi,Laszlo Halasz et al.
Marta Kotorman et al.
The aim of the present study was to examine the potential role and applicability of dietary supplements in reducing the risk of development of amyloid diseases associated with the gastrointestinal tract, such as type II diabetes. Trypsin, a...
Transforming Cytosolic Proteins into "Insoluble" and Membrane-toxic Forms Triggering Diseases/Aging by Genetic, Pathological or Environmental Factors [0.03%]
遗传、病理或环境因素可将细胞质蛋白转化为引发疾病的“不溶”和膜毒性形式
Jianxing Song
Jianxing Song
An increasing spectrum of diseases more than neurodegenerative diseases is characteristic of aggregation of specific proteins, while aggregation of a large number of non-specific proteins are associated with aging down to Escherichia coli. ...
Jennifer M Redington,Leonid Breydo,Vladimir N Uversky
Jennifer M Redington
Protein therapeutics are playing an increasingly important role in treatment of a variety of human diseases. However, like the rest of proteins, they are susceptible to aggregation. Aggregation of proteinaceous pharmaceuticals can cause a l...
Streptomyces as Overexpression System for Heterologous Production of an Antimicrobial Peptide [0.03%]
链霉菌作为异源产生抗菌肽的过表达系统
Marisol Roldán-Tapia,Jozef Anné,Ana Gisela Reyes et al.
Marisol Roldán-Tapia et al.
Background: Antimicrobial peptides could be used in several fields of application, and large quantities of antimicrobial peptides would be required. However, their production is very expensive; this is why a suitable prod...
Jun-Xia Lu,Xing-Qi Dong,Jian-Jun Zhang
Jun-Xia Lu
Alzheimer's disease (AD) has become the most common neurodegenerative disease. The deposition of amyloid fibrils in the brain is one of the characteristics of AD. The fibrils are composed of amyloid-β peptide (Aβ). Aβ is produced through...
Cold Shock Protein A from Corynebacterium pseudotuberculosis: Role of Electrostatic Forces in the Stability of the Secondary Structure [0.03%]
产假性分枝杆菌冷休克蛋白A：静电作用在二级结构稳定性中的作用
Monika A Coronado,Icaro P Caruso,Vinicius M de Oliveira et al.
Monika A Coronado et al.
The conformational stability of the Cold shock protein A (CspA) from C. pseudotuberculosis (Cp), a nucleic acid binding protein in function of pH and salt concentration was examined by using differential scanning calorimetry and CD spectros...
Taoyan Yuan,Zhongxin Sun,Wanqiu Zhao et al.
Taoyan Yuan et al.
Phoenixin (PNX), a newly identified peptide cleaved from the C-terminus of protein C4orf52, mainly exists in two active isoforms, phoenixin-14 (PNX-14) amide and phoenixin-20 (PNX-20) amide that were first isolated from the rat hypothalamus...