Stromal myofibroblasts accompany modifications in the epithelial phenotype of tongue dysplastic and malignant lesions [0.03%]
舌黏膜癌前及恶性病变的上皮表型改变伴发间质肌成纤维细胞浸润
Marilena Vered,Irit Allon,Amos Buchner et al.
Marilena Vered et al.
Stromal myofibroblasts (SMF) associated with various types of carcinomas are believed to emerge under the influence of the tumor cells. Recent studies have shown that SMF may originate from fibroblasts within the tumor stroma or even from c...
Regulated expression of CCL21 in the prostate tumor microenvironment inhibits tumor growth and metastasis in an orthotopic model of prostate cancer [0.03%]
在前列腺癌原位模型中，调节前列腺肿瘤微环境中CCL21的表达可抑制肿瘤生长和转移
Nazita Yousefieh,Suzanne M Hahto,Amber L Stephens et al.
Nazita Yousefieh et al.
Currently there are no curative therapies available for patients with metastatic prostate cancer. Thus, novel therapies are needed to treat this patient population. Immunotherapy represents one promising approach for the elimination of occu...
Identification of molecular distinctions between normal breast-associated fibroblasts and breast cancer-associated fibroblasts [0.03%]
识别正常乳腺相关成纤维细胞与乳腺癌相关成纤维细胞的分子差异
Andrea Sadlonova,Damon B Bowe,Zdenek Novak et al.
Andrea Sadlonova et al.
Stromal fibroblasts influence the behavior of breast epithelial cells. Fibroblasts derived from normal breast (NAF) inhibit epithelial growth, whereas fibroblasts from breast carcinomas (CAF) have less growth inhibitory capacity and can pro...
Genotype-dependent tumor regression in Marek's disease mediated at the level of tumor immunity [0.03%]
根据基因型依赖的肿瘤免疫介导的马立克病中的肿瘤消退
Shyamesh Kumar,Joram J Buza,Shane C Burgess
Shyamesh Kumar
Marek's disease (MD) of chickens is a unique natural model of Hodgkin's and Non Hodgkin's lymphomas in which the neoplastically-transformed cells over-express CD30 (CD30(hi)) antigen. All chicken genotypes can be infected with MD virus and ...
Dual FGF-2 and intergrin alpha5beta1 signaling mediate GRAF-induced RhoA inactivation in a model of breast cancer dormancy [0.03%]
FGF-2和整合素alpha5beta1信号共同调控GRAF诱导的乳腺癌休眠模型中的RhoA失活现象
Judith Barrios,Robert Wieder
Judith Barrios
Interactions with the bone marrow stroma regulate dormancy and survival of breast cancer micrometastases. In an in vitro model of dormancy in the bone marrow, we previously demonstrated that estrogen-dependent breast cancer cells are partia...
Nuclear localization of CXCR4 determines prognosis for colorectal cancer patients [0.03%]
CXCR4核定位决定结直肠癌患者的预后
Frank M Speetjens,Gerrit Jan Liefers,Cornelis J Korbee et al.
Frank M Speetjens et al.
Chemokines and their receptors are implicated in formation of colorectal cancer metastases. Especially CXCR4 is an important factor, determining migration, invasiveness, metastasis and proliferation of colorectal cancer cells. Object of thi...